Epidemiology Study of Malaria Transmission Intensity in Africa

• Sponsor: GlaxoSmithKline (Industry)
• Overall Status: Completed
• CT.gov ID: NCT01190202
• Collaborator: The PATH Malaria Vaccine Initiative (MVI) (Other)
• Enrollment: 21,618
• Locations: 8
• Arms: 4
• Actual Duration (Months): 33.2
• Patients Per Site: 2702.3
• Patients Per Site Per Month: 81.3

Study Details

Study Description

Brief Summary

The aim of this epidemiology study is to characterize in a standardized way malaria transmission intensity at the clinical trial centers participating in study 110021 (NCT00866619).

Condition or Disease	Intervention/Treatment	Phase
Malaria; Malaria Vaccines	Procedure: Blood sampling; Procedure: Assessment of body temperature	N/A

Detailed Description

This study is a multicenter epidemiology study at centers that are participating in GSK's pivotal Phase III candidate malaria vaccine 110021 ( NCT00866619) trial and will involve 4 annual cross sectional surveys performed preferably at peak transmission.

There will be no study vaccine administered in this epidemiology study.

Study Design

• Study Type: Interventional
• Actual Enrollment: 21618 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Primary Purpose: Other
• Official Title: Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa
• Actual Study Start Date: Mar 14, 2011
• Actual Primary Completion Date: Dec 20, 2013
• Actual Study Completion Date: Dec 20, 2013

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Overall Study Group (Survey 1) Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Procedure: Blood sampling; Capillary blood samples collected by finger/heel prick; Procedure: Assessment of body temperature; Assessment of axial body temperature with a digital thermometer
Experimental: Overall Study Group (Survey 2) Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Procedure: Blood sampling; Capillary blood samples collected by finger/heel prick; Procedure: Assessment of body temperature; Assessment of axial body temperature with a digital thermometer
Experimental: Overall Study Group (Survey 3) Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Procedure: Blood sampling; Capillary blood samples collected by finger/heel prick; Procedure: Assessment of body temperature; Assessment of axial body temperature with a digital thermometer
Experimental: Overall Study Group (Survey 4) Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Procedure: Blood sampling; Capillary blood samples collected by finger/heel prick; Procedure: Assessment of body temperature; Assessment of axial body temperature with a digital thermometer

Outcome Measures

Primary Outcome Measures

1. Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), for Each Survey [At each Survey visit]

   The Overall parasite prevalence (PP) data were collected across centers from subjects aged between and including: 6 months to 4 Years (6M-4Y), 5 to 19 Years (5-19 Y) and 20 Years or older (20Y+), for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.

Secondary Outcome Measures

1. Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey [At each Survey visit]

   The overall parasite prevalence (PP) data were collected across centers from subjects aged 4 years or less, for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.

2. Number of Subjects With Anemia and Severe Anemia for Each Survey [During the survey period (approximatively 1 year)]

   The overall anemia and severe anemia data were collected across centers from subjects, aged between and including: 6M-4Y, 5-19 Y and 20Y+, for each survey. Hemoglobin (Hgb) cut-offs used to define anemia and severe anemia in people living at sea level are: Anemia: children 6M to 5Y, Hgb lower than (<) 11 gram per deciliter (g/dL); children 5-11Y, Hgb <11.5 g/dL; children 12-13Y, Hgb <12 g/dL; non-pregnant females, Hgb <12 g/dL; pregnant females, Hgb <11 g/dL; males, Hgb <13 g/dL. Severe anemia: any age or gender, Hgb <7 g/dL. Missing/ Not applicable (NA) = if age or pregnancy status was not available. Among each age category, results for both sub-categories "Yes" (subjects with anemia) and "Missing/NA" are presented below, results for the category "No" can be deduced from the number of participants analyzed in the corresponding age category, minus (number of "Yes" + number of "Missing/NA"). Similar presentation is followed for "severe anemia" results.

3. Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density [During the survey period (approximatively 1 year)]

   The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.

4. Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density [During the survey period (approximatively 1 year)]

   The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.

5. Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density [During the survey period (approximatively 1 year)]

   The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.

6. Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density [During the survey period (approximatively 1 year)]

   The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.

7. Mean Number of Days With Malaria Treatment at Survey 1 [During the 14 day-period before the malaria treatment]

   The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

8. Mean Number of Days With Malaria Treatment at Survey 2 [During the 14 day-period before the malaria treatment]

   The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

9. Mean Number of Days With Malaria Treatment at Survey 3 [During the 14 day-period before the malaria treatment]

   The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

10. Mean Number of Days With Malaria Treatment at Survey 4 [During the 14 day-period before the malaria treatment]

    The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

11. Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1 [In the last 24 hours or at the survey visit]

    Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

12. Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2 [In the last 24 hours or at the survey visit]

    Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

13. Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3 [In the last 24 hours or at the survey visit]

    Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

14. Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4 [In the last 24 hours or at the survey visit]

    Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

15. Mean Number of Days With Fever at Survey 1 [During the survey period (approximatively 1 year)]

    The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

16. Mean Number of Days With Fever at Survey 2 [During the survey period (approximatively 1 year)]

    The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

17. Mean Number of Days With Fever at Survey 3 [During the survey period (approximatively 1 year)]

    The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

18. Mean Number of Days With Fever at Survey 4 [During the survey period (approximatively 1 year)]

    The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

19. Axillary Temperature at Visit in Survey 1 [At Survey visit]

    The mean and standard deviation of the axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

20. Axillary Temperature at Visit in Survey 2 [At Survey visit]

    The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

21. Axillary Temperature at Visit in Survey 3 [At Survey visit]

    The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

22. Axillary Temperature at Visit in Survey 4 [At Survey visit]

    The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

23. Number of Subjects Living in the Same House at Survey 1 [At Survey visit]

    The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

24. Number of Subjects Living in the Same House at Survey 2 [At Survey visit]

    The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

25. Number of Subjects Living in the Same House at Survey 3 [At Survey visit]

    The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

26. Number of Subjects Living in the Same House at Survey 4 [At Survey visit]

    The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

27. Mean Number of Subjects Living in the Same House at Survey 1 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

28. Mean Number of Subjects Living in the Same House at Survey 2 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

29. Mean Number of Subjects Living in the Same House at Survey 3 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

30. Mean Number of Subjects Living in the Same House at Survey 4 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

31. Number of Subjects by Localisation and Type of Location at Survey 1 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural or missing) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants or missing type of location). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

32. Number of Subjects by Localisation and Type of Location at Survey 2 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

33. Number of Subjects by Localisation and Type of Location at Survey 3 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

34. Number of Subjects by Localisation and Type of Location at Survey 4 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

35. Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other and missing. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, parquet polished wood, vinyl or asphalt strips, ceramic tiles, cement, carpet, missing. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

36. Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, parquet polished wood, vinyl or asphalt strips, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

37. Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

38. Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, vinyl or asphalt strips, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

39. Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other, missing. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open, missing. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows, missing. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

40. Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

41. Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

42. Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

43. Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water), missing; and Presence of electricity (PE): Yes, No, missing. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

44. Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

45. Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

46. Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4 [At Survey visit]

    The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).

47. Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey [At each Survey visit]

    The malaria prevention measures (MPM) data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for each Survey. The MPM results include the following categories: Use of Mosquito coils over 7 days (UMc > 7D), Use of Insecticide spray over 7 days (UIs > 7D), Use of Commercial Repellents over 7 days (UCR > 7D), Use of Traditional Repellents over 7 days (UTR > 7D), Use of none of above over 7 days (Una >7D), Use of indoor residual spray in past 12 months to spray interior walls (Uirs past 12M), Use of indoor residual spray - number of months ago (Uirs-nM) or Use of indoor residual spray- no spray (Uirs-no spray): the number of months ago for each Uirs-nM sub-categories is defined using the following [x Months]. Not all Uirs-nM sub-categories were analyzed in each survey.

48. Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1 [At Survey visit]

    Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.

49. Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2 [At Survey visit]

    Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.

50. Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3 [At Survey visit]

    Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.

51. Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4 [At Survey visit]

    Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.

52. Number of Subjects With Serious Adverse Events (SAEs) Related to Study Procedure for Each Survey [At each Survey visit]

    Serious adverse events (SAEs) assessed include medical occurrences that result in death, are life threatening, require hospitalization or prolongation of hospitalization or result in disability/incapacity. Capillary blood sampling was the only invasive procedure involved in this study. SAEs related to this procedure were recorded at the Survey visit.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 6 Months and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Subjects who the investigator believes that they and/or their parent(s)/Legally Acceptable Representative(s) can and will comply with the requirements of the protocol.

• A male or female 6 months or older at the time of survey.

• Written informed consent obtained from the subject/from the parent(s)/ Legally Acceptable Representative(s) of the subject.

Exclusion Criteria:

• Child in care.

• Previous or current participation in any malaria vaccine trial.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	GSK Investigational Site	Ouagadougou 01		Burkina Faso
2	GSK Investigational Site	Lambaréné		Gabon
3	GSK Investigational Site	Kintampo		Ghana
4	GSK Investigational Site	Kumasi		Ghana
5	GSK Investigational Site	Kisumu		Kenya
6	GSK Investigational Site	Lilongwe		Malawi
7	GSK Investigational Site	Dar-es-Salaam		Tanzania
8	GSK Investigational Site	Korogwe, Tanga		Tanzania

Sponsors and Collaborators

• GlaxoSmithKline
• The PATH Malaria Vaccine Initiative (MVI)

Investigators

• Study Director: GSK Clinical Trials, GlaxoSmithKline

Study Documents (Full-Text)

None provided.

More Information

Publications

• Drakeley C, Abdulla S, Agnandji ST, Fernandes JF, Kremsner P, Lell B, Mewono L, Bache BE, Mihayo MG, Juma O, Tanner M, Tahita MC, Tinto H, Diallo S, Lompo P, D'Alessandro U, Ogutu B, Otieno L, Otieno S, Otieno W, Oyieko J, Asante KP, Dery DB, Adjei G, Adeniji E, Atibilla D, Owusu-Agyei S, Greenwood B, Gesase S, Lusingu J, Mahende C, Mongi R, Segeja M, Adjei S, Agbenyega T, Agyekum A, Ansong D, Bawa JT, Boateng HO, Dandalo L, Escamilla V, Hoffman I, Maenje P, Martinson F, Carter T, Leboulleux D, Kaslow DC, Usuf E, Pirçon JY, Bahmanyar ER. Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries. Malar J. 2017 Oct 27;16(1):433. doi: 10.1186/s12936-017-2078-3.

• Responsible Party: GlaxoSmithKline
• ClinicalTrials.gov Identifier: NCT01190202
• Other Study ID Numbers: 114001
• First Posted: Aug 27, 2010
• Last Update Posted: Aug 18, 2020
• Last Verified: Aug 1, 2020

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Keywords provided by GlaxoSmithKline: Malaria; Plasmodium falciparum
• Additional relevant MeSH terms: Malaria

Study Results

Participant Flow

Recruitment Details	For each year and each site, approximately 400 subjects at least 6 months and < 5 years old, approximately 200 subjects at least 5 years and < 20 years old and approximately 200 subjects at least 20 years old were to be enrolled. The study was conducted at 8 sites and 6 countries for the first 3 surveys and 3 sites from 3 countries for Survey 4.

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
Period Title: Overall Study
STARTED	6404	6414	6400	2400
COMPLETED	6404	6414	6400	2400
NOT COMPLETED	0	0	0	0

Baseline Characteristics

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)	Total
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Total of all reporting groups
Overall Participants	6404	6414	6400	2400	21618
Age (Years) [Mean (Standard Deviation) ]
Mean (Standard Deviation) [Years]	12.6 (14.6)	12.1 (14.3)	12.1 (14.2)	12.4 (14.4)	12.28 (14.37)
Sex: Female, Male (Count of Participants)
Female	3670 57.3%	3791 59.1%	3752 58.6%	1420 59.2%	12633 58.4%
Male	2734 42.7%	2623 40.9%	2648 41.4%	980 40.8%	8985 41.6%
Race and Ethnicity Not Collected (Count of Participants)
Count of Participants [Participants]	0 0%

Outcome Measures

1. Primary Outcome

Title	Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), for Each Survey
Description	The Overall parasite prevalence (PP) data were collected across centers from subjects aged between and including: 6 months to 4 Years (6M-4Y), 5 to 19 Years (5-19 Y) and 20 Years or older (20Y+), for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.
Time Frame	At each Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
Measure Participants	6401	6411	6400	2399
6M-4Y, Overall	720 11.2%	574 8.9%	605 9.5%	345 14.4%
5-19Y, Overall	446 7%	469 7.3%	483 7.5%	278 11.6%
20+Y, Overall	147 2.3%	146 2.3%	193 3%	92 3.8%

2. Secondary Outcome

Title	Number of Subjects With Plasmodium Falciparum (P. Falciparum) Parasitaemia (PFP), According to Annual Age for Children of 4 Years or Less, for Each Survey
Description	The overall parasite prevalence (PP) data were collected across centers from subjects aged 4 years or less, for each Survey. The number of subjects P. Falciparum parasitemia infected among the number of subjects with known result for P.falciparum parasitemia test was tabulated.
Time Frame	At each Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
Measure Participants	3200	3197	3193	1193
Children aged 0 year	21 0.3%	38 0.6%	41 0.6%	25 1%
Children aged 1 year	94 1.5%	75 1.2%	128 2%	62 2.6%
Children aged 2 years	139 2.2%	122 1.9%	125 2%	86 3.6%
Children aged 3 years	223 3.5%	174 2.7%	135 2.1%	86 3.6%
Children aged 4 years	243 3.8%	165 2.6%	176 2.8%	86 3.6%

3. Secondary Outcome

Title	Number of Subjects With Anemia and Severe Anemia for Each Survey
Description	The overall anemia and severe anemia data were collected across centers from subjects, aged between and including: 6M-4Y, 5-19 Y and 20Y+, for each survey. Hemoglobin (Hgb) cut-offs used to define anemia and severe anemia in people living at sea level are: Anemia: children 6M to 5Y, Hgb lower than (<) 11 gram per deciliter (g/dL); children 5-11Y, Hgb <11.5 g/dL; children 12-13Y, Hgb <12 g/dL; non-pregnant females, Hgb <12 g/dL; pregnant females, Hgb <11 g/dL; males, Hgb <13 g/dL. Severe anemia: any age or gender, Hgb <7 g/dL. Missing/ Not applicable (NA) = if age or pregnancy status was not available. Among each age category, results for both sub-categories "Yes" (subjects with anemia) and "Missing/NA" are presented below, results for the category "No" can be deduced from the number of participants analyzed in the corresponding age category, minus (number of "Yes" + number of "Missing/NA"). Similar presentation is followed for "severe anemia" results.
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
Measure Participants	6401	6411	6400	2399
Overall Yes, Anaemia, 6M-4Y	1974 30.8%	2025 31.6%	1974 30.8%	871 36.3%
Missing/NA Anemia, 6M-4Y	4 0.1%	2 0%
Overall Yes, Anemia, 5-19Y	806 12.6%	794 12.4%	765 12%	371 15.5%
Missing/NA Anemia, 5-19Y	2 0%	2 0%
Overall Yes, Anemia, 20Y+	673 10.5%	631 9.8%	651 10.2%	313 13%
Missing/NA Anemia, 20Y+	1 0%	0 0%
Overall Yes, Severe anaemia, 6M-4Y	85 1.3%	70 1.1%	84 1.3%	34 1.4%
Missing/NA Severe anemia, 6M-4Y	1226 19.1%	1172 18.3%	1219 19%	322 13.4%
Overall Yes, Severe anaemia, 5-19Y	10 0.2%	12 0.2%	19 0.3%	5 0.2%
Missing/NA Severe anemia, 5-19Y	807 12.6%	833 13%	847 13.2%	235 9.8%
Overall Yes, Severe anaemia, 20Y+	17 0.3%	14 0.2%	9 0.1%	4 0.2%
Missing/NA Severe anemia, 20Y+	915 14.3%	956 14.9%	944 14.8%	287 12%

4. Secondary Outcome

Title	Number of Subjects With Anti-malarial Therapy in Survey 1, According to Parasite Density
Description	The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, MT in past 14 days, Yes	22 0.3%	9 0.1%	2 0%	12 0.5%	262 1.2%
6M-4Y, MT in past 14 days, No	351 5.5%	161 2.5%	56 0.9%	107 4.5%	2218 10.3%
6M-4Y, EDMT *, Ongoing	3 0%	2 0%	0 0%	0 0%	28 0.1%
6M-4Y, EDMT *, 1-3 days	18 0.3%	5 0.1%	2 0%	9 0.4%	206 1%
6M-4Y, EDMT *, ≥ 4days	1 0%	2 0%	0 0%	3 0.1%	27 0.1%
6M-4Y, EDMT *, Missing/Not applicable	351 5.5%	161 2.5%	56 0.9%	107 4.5%	2219 10.3%
6M-4Y, OM in past 14 days, Yes	35 0.5%	33 0.5%	21 0.3%	33 1.4%	445 2.1%
6M-4Y, OM in past 14 days, No	338 5.3%	137 2.1%	37 0.6%	86 3.6%	2035 9.4%
6M-4Y, DOM *, Ongoing	8 0.1%	7 0.1%	2 0%	5 0.2%	79 0.4%
6M-4Y, DOM *, 1-7 days	25 0.4%	26 0.4%	19 0.3%	27 1.1%	365 1.7%
6M-4Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	1 0%
6M-4Y, DOM *, Missing/Not applicable	340 5.3%	137 2.1%	37 0.6%	87 3.6%	2035 9.4%
6M-4Y, MH in the last 3 months, Yes	7 0.1%	4 0.1%	1 0%	7 0.3%	90 0.4%
6M-4Y, MH in the last 3 months, No	366 5.7%	166 2.6%	57 0.9%	112 4.7%	2390 11.1%
5-19Y, MT in past 14 days, Yes	5 0.1%	6 0.1%	4 0.1%	2 0.1%	85 0.4%
5-19Y, MT in past 14 days, No	289 4.5%	65 1%	19 0.3%	56 2.3%	1082 5%
5-19Y, EDMT *, Ongoing	1 0%	0 0%	0 0%	0 0%	5 0%
5-19Y, EDMT *, 1-3 days	4 0.1%	6 0.1%	4 0.1%	1 0%	75 0.3%
5-19Y, EDMT *, ≥ 4days	0 0%	0 0%	0 0%	1 0%	5 0%
5-19Y, EDMT *, Missing/Not applicable	289 4.5%	65 1%	19 0.3%	56 2.3%	1082 5%
5-19Y, OM in past 14 days, Yes	29 0.5%	12 0.2%	8 0.1%	7 0.3%	143 0.7%
5-19Y, OM in past 14 days, No	265 4.1%	59 0.9%	15 0.2%	51 2.1%	1024 4.7%
5-19Y, DOM *, Ongoing	4 0.1%	1 0%	1 0%	2 0.1%	17 0.1%
5-19Y, DOM *, 1-7 days	25 0.4%	11 0.2%	7 0.1%	5 0.2%	125 0.6%
5-19Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, DOM *, Missing/Not applicable	265 4.1%	59 0.9%	15 0.2%	51 2.1%	1025 4.7%
5-19Y, MH in the last 3 months, Yes	0 0%	3 0%	0 0%	1 0%	24 0.1%
5-19Y, MH in the last 3 months, No	294 4.6%	68 1.1%	23 0.4%	57 2.4%	1143 5.3%
20Y+, MT in past 14 days, Yes	1 0%	0 0%	0 0%	102 4.3%
20Y+, MT in past 14 days, No	118 1.8%	17 0.3%	11 0.2%	1339 55.8%
20Y+, EDMT *, Ongoing	0 0%	0 0%	0 0%	14 0.6%
20Y+, EDMT *, 1-3 days	1 0%	0 0%	0 0%	80 3.3%
20Y+, EDMT *, ≥ 4days	0 0%	0 0%	0 0%	8 0.3%
20Y+, EDMT *, Missing/Not applicable	118 1.8%	17 0.3%	11 0.2%	1339 55.8%
20Y+, OM in past 14 days, Yes	20 0.3%	6 0.1%	2 0%	203 8.5%
20Y+, OM in past 14 days, No	99 1.5%	11 0.2%	9 0.1%	1238 51.6%
20Y+, DOM *, Ongoing	5 0.1%	1 0%	1 0%	41 1.7%
20Y+, DOM *, 1-7 days	15 0.2%	5 0.1%	1 0%	158 6.6%
20Y+, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	2 0.1%
20Y+, DOM *, Missing/Not applicable	99 1.5%	11 0.2%	9 0.1%	1240 51.7%
20Y+, MH in the last 3 months, Yes	0 0%	2 0%	0 0%	18 0.8%
20Y+, MH in the last 3 months, No	119 1.9%	15 0.2%	11 0.2%	1423 59.3%

5. Secondary Outcome

Title	Number of Subjects With Anti-malarial Therapy in Survey 2, According to Parasite Density
Description	The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, MT in past 14 days, Yes	14 0.2%	6 0.1%	2 0%	5 0.2%	257 1.2%
6M-4Y, MT in past 14 days, No	269 4.2%	142 2.2%	65 1%	71 3%	2366 10.9%
6M-4Y, EDMT *, Ongoing	1 0%	3 0%	0 0%	1 0%	25 0.1%
6M-4Y, EDMT *, 1-3 days	12 0.2%	1 0%	1 0%	4 0.2%	206 1%
6M-4Y, EDMT *, ≥ 4days	1 0%	2 0%	1 0%	0 0%	26 0.1%
6M-4Y, EDMT *, Missing/NA	269 4.2%	142 2.2%	65 1%	71 3%	2366 10.9%
6M-4Y, OM in past 14 days, Yes	42 0.7%	15 0.2%	9 0.1%	17 0.7%	535 2.5%
6M-4Y, OM in past 14 days, No	241 3.8%	133 2.1%	58 0.9%	59 2.5%	2088 9.7%
6M-4Y, DOM *, Ongoing	12 0.2%	6 0.1%	3 0%	2 0.1%	118 0.5%
6M-4Y, DOM *, 1-7 days	30 0.5%	9 0.1%	6 0.1%	15 0.6%	410 1.9%
6M-4Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	7 0%
6M-4Y, DOM *, Missing/NA	241 3.8%	133 2.1%	58 0.9%	59 2.5%	2088 9.7%
6M-4Y, MH in the last 3 months, Yes	3 0%	3 0%	2 0%	3 0.1%	77 0.4%
6M-4Y, MH in the last 3 months, No	280 4.4%	145 2.3%	65 1%	73 3%	2546 11.8%
5-19Y, MT in past 14 days, Yes	11 0.2%	3 0%	2 0%	4 0.2%	77 0.4%
5-19Y, MT in past 14 days, No	322 5%	68 1.1%	27 0.4%	32 1.3%	1081 5%
5-19Y, EDMT *, Ongoing	1 0%	1 0%	0 0%	0 0%	11 0.1%
5-19Y, EDMT *, 1-3 days	8 0.1%	1 0%	2 0%	4 0.2%	66 0.3%
5-19Y, EDMT *, ≥ 4days	2 0%	1 0%	0 0%	0 0%	0 0%
5-19Y, EDMT *, Missing/NA	322 5%	68 1.1%	27 0.4%	32 1.3%	1081 5%
5-19Y, OM in past 14 days, Yes	33 0.5%	10 0.2%	8 0.1%	9 0.4%	134 0.6%
5-19Y, OM in past 14 days, No	300 4.7%	61 1%	21 0.3%	27 1.1%	1024 4.7%
5-19Y, DOM *, Ongoing	7 0.1%	1 0%	0 0%	1 0%	30 0.1%
5-19Y, DOM *, 1-7 days	26 0.4%	9 0.1%	8 0.1%	8 0.3%	102 0.5%
5-19Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	2 0%
5-19Y, DOM *, Missing/NA	300 4.7%	61 1%	21 0.3%	27 1.1%	1024 4.7%
5-19Y, MH in the last 3 months, Yes	5 0.1%	1 0%	1 0%	1 0%	19 0.1%
5-19Y, MH in the last 3 months, No	328 5.1%	70 1.1%	28 0.4%	35 1.5%	1139 5.3%
20Y+, MT in past 14 days, Yes	2 0%	0 0%	0 0%	2 0.1%	84 0.4%
20Y+, MT in past 14 days, No	122 1.9%	10 0.2%	5 0.1%	5 0.2%	1357 6.3%
20Y+, EDMT *, Ongoing	0 0%	0 0%	0 0%	1 0%	5 0%
20Y+, EDMT *, 1-3 days	2 0%	0 0%	0 0%	1 0%	72 0.3%
20Y+, EDMT *, ≥ 4days	0 0%	0 0%	0 0%	0 0%	7 0%
20Y+, EDMT *, Missing/NA	122 1.9%	10 0.2%	5 0.1%	5 0.2%	1357 6.3%
20Y+, OM in past 14 days, Yes	10 0.2%	2 0%	2 0%	3 0.1%	214 1%
20Y+, OM in past 14 days, No	114 1.8%	8 0.1%	3 0%	4 0.2%	1227 5.7%
20Y+, DOM *, Ongoing	1 0%	0 0%	1 0%	2 0.1%	71 0.3%
20Y+, DOM *, 1-7 days	9 0.1%	2 0%	1 0%	1 0%	138 0.6%
20Y+, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	5 0%
20Y+, DOM *, Missing/NA	114 1.8%	8 0.1%	3 0%	4 0.2%	1227 5.7%
20Y+, MH in the last 3 months, Yes	1 0%	1 0%	0 0%	0 0%	19 0.1%
20Y+, MH in the last 3 months, No	123 1.9%	9 0.1%	5 0.1%	7 0.3%	1422 6.6%

6. Secondary Outcome

Title	Number of Subjects With Anti-malarial Therapy in Survey 3, According to Parasite Density
Description	The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, MT in past 14 days, Yes	17 0.3%	13 0.2%	3 0%	9 0.4%	267 1.2%
6M-4Y, MT in past 14 days, No	262 4.1%	148 2.3%	71 1.1%	82 3.4%	2321 10.7%
6M-4Y, EDMT *, Ongoing	4 0.1%	1 0%	0 0%	4 0.2%	33 0.2%
6M-4Y, EDMT *, 1-3 days	11 0.2%	10 0.2%	3 0%	5 0.2%	210 1%
6M-4Y, EDMT *, ≥ 4days	2 0%	2 0%	0 0%	0 0%	24 0.1%
6M-4Y, EDMT *, Missing/NA	262 4.1%	148 2.3%	71 1.1%	82 3.4%	2321 10.7%
6M-4Y, OM in past 14 days, Yes	65 1%	30 0.5%	18 0.3%	18 0.8%	547 2.5%
6M-4Y, OM in past 14 days, No	214 3.3%	131 2%	56 0.9%	73 3%	2041 9.4%
6M-4Y, DOM *, Ongoing	10 0.2%	8 0.1%	3 0%	6 0.3%	142 0.7%
6M-4Y, DOM *, 1-7 days	55 0.9%	22 0.3%	15 0.2%	12 0.5%	394 1.8%
6M-4Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	11 0.1%
6M-4Y, DOM *, Missing/NA	214 3.3%	131 2%	56 0.9%	73 3%	2041 9.4%
6M-4Y, MH in the last 3 months, Yes	14 0.2%	4 0.1%	3 0%	0 0%	99 0.5%
6M-4Y, MH in the last 3 months, No	265 4.1%	157 2.4%	71 1.1%	91 3.8%	2489 11.5%
5-19Y, MT in past 14 days, Yes	14 0.2%	4 0.1%	1 0%	1 0%	58 0.3%
5-19Y, MT in past 14 days, No	327 5.1%	90 1.4%	12 0.2%	34 1.4%	1071 5%
5-19Y, EDMT *, Ongoing	4 0.1%	1 0%	0 0%	0 0%	4 0%
5-19Y, EDMT *, 1-3 days	8 0.1%	3 0%	1 0%	1 0%	50 0.2%
5-19Y, EDMT *, ≥ 4days	2 0%	0 0%	0 0%	0 0%	4 0%
5-19Y, EDMT *, Missing/NA	327 5.1%	90 1.4%	12 0.2%	34 1.4%	1071 5%
5-19Y, OM in past 14 days, Yes	44 0.7%	18 0.3%	3 0%	13 0.5%	128 0.6%
5-19Y, OM in past 14 days, No	297 4.6%	76 1.2%	10 0.2%	22 0.9%	1001 4.6%
5-19Y, DOM *, Ongoing	13 0.2%	1 0%	0 0%	2 0.1%	19 0.1%
5-19Y, DOM *, 1-7 days	31 0.5%	17 0.3%	3 0%	11 0.5%	109 0.5%
5-19Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, DOM *, Missing/NA	297 4.6%	76 1.2%	10 0.2%	22 0.9%	1001 4.6%
5-19Y, MH in the last 3 months, Yes	7 0.1%	0 0%	0 0%	1 0%	17 0.1%
5-19Y, MH in the last 3 months, No	334 5.2%	94 1.5%	13 0.2%	34 1.4%	1112 5.1%
20Y+, MT in past 14 days, Yes	5 0.1%	2 0%	0 0%	0 0%	70 0.3%
20Y+, MT in past 14 days, No	166 2.6%	11 0.2%	5 0.1%	4 0.2%	1332 6.2%
20Y+, EDMT *, Ongoing	0 0%	0 0%	0 0%	0 0%	6 0%
20Y+, EDMT *, 1-3 days	5 0.1%	1 0%	0 0%	0 0%	63 0.3%
20Y+, EDMT *, ≥ 4days	0 0%	1 0%	0 0%	0 0%	1 0%
20Y+, EDMT *, Missing/NA	166 2.6%	11 0.2%	5 0.1%	4 0.2%	1332 6.2%
20Y+, OM in past 14 days, Yes	25 0.4%	3 0%	3 0%	1 0%	227 1.1%
20Y+, OM in past 14 days, No	146 2.3%	10 0.2%	2 0%	3 0.1%	1175 5.4%
20Y+, DOM *, Ongoing	5 0.1%	3 0%	0 0%	1 0%	70 0.3%
20Y+, DOM *, 1-7 days	19 0.3%	0 0%	3 0%	0 0%	151 0.7%
20Y+, DOM *, ≥ 8 days	1 0%	0 0%	0 0%	0 0%	6 0%
20Y+, DOM *, Missing/NA	146 2.3%	10 0.2%	2 0%	3 0.1%	1175 5.4%
20Y+, MH in the last 3 months, Yes	0 0%	0 0%	0 0%	0 0%	12 0.1%
20Y+, MH in the last 3 months, No	171 2.7%	13 0.2%	5 0.1%	4 0.2%	1390 6.4%

7. Secondary Outcome

Title	Number of Subjects With Anti-malarial Therapy in Survey 4, According to Parasite Density
Description	The overall anti-malaria therapy data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg). Results include the following categories: Malaria treatment (MT) in past 14 days with sub-categories assessed: Yes, No; Exact days of malaria treatment (EDMT) with sub-categories assessed: Ongoing, 1-3 Days, ≥ 4 Days, Missing/NA; Other medication (OM) in past 14 days with sub-categories assessed: Yes, No; Days of other medication (DOM) with sub-categories assessed: Ongoing, 1-7 Days, ≥ 8 Days, Missing/NA; Malaria hospitalization (MH) in the last 3 months with sub-categories assessed: Yes, No. Missing/NA = Missing or Not Applicable.* In case of several medication (malaria treatment or other medication) taken per subject, the maximum duration was computed for this study.
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, MT in past 14 days, Yes	5 0.1%	2 0%	1 0%	5 0.2%	71 0.3%
6M-4Y, MT in past 14 days, No	163 2.5%	101 1.6%	19 0.3%	49 2%	777 3.6%
6M-4Y, EDMT *, Ongoing	2 0%	1 0%	0 0%	4 0.2%	21 0.1%
6M-4Y, EDMT *, 1-3 days	3 0%	1 0%	1 0%	1 0%	49 0.2%
6M-4Y, EDMT *, ≥ 4days	0 0%	0 0%	0 0%	0 0%	1 0%
6M-4Y, EDMT *, Missing/NA	163 2.5%	101 1.6%	19 0.3%	49 2%	777 3.6%
6M-4Y, OM in past 14 days, Yes	21 0.3%	11 0.2%	7 0.1%	12 0.5%	152 0.7%
6M-4Y, OM in past 14 days, No	147 2.3%	92 1.4%	13 0.2%	42 1.8%	696 3.2%
6M-4Y, DOM *, Ongoing	5 0.1%	2 0%	3 0%	5 0.2%	48 0.2%
6M-4Y, DOM *, 1-7 days	16 0.2%	8 0.1%	4 0.1%	7 0.3%	103 0.5%
6M-4Y, DOM *, ≥ 8 days	0 0%	1 0%	0 0%	0 0%	1 0%
6M-4Y, DOM *, Missing/NA	147 2.3%	92 1.4%	13 0.2%	42 1.8%	696 3.2%
6M-4Y, MH in the last 3 months, Yes	9 0.1%	1 0%	0 0%	2 0.1%	28 0.1%
6M-4Y, MH in the last 3 months, No	159 2.5%	102 1.6%	20 0.3%	52 2.2%	820 3.8%
5-19Y, MT in past 14 days, Yes	2 0%	0 0%	0 0%	0 0%	10 0%
5-19Y, MT in past 14 days, No	196 3.1%	51 0.8%	16 0.3%	13 0.5%	318 1.5%
5-19Y, EDMT *, Ongoing	0 0%	0 0%	0 0%	0 0%	3 0%
5-19Y, EDMT *, 1-3 days	2 0%	0 0%	0 0%	0 0%	7 0%
5-19Y, EDMT *, ≥ 4days	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, EDMT *, Missing/NA	196 3.1%	51 0.8%	16 0.3%	13 0.5%	318 1.5%
5-19Y, OM in past 14 days, Yes	13 0.2%	4 0.1%	0 0%	2 0.1%	28 0.1%
5-19Y, OM in past 14 days, No	185 2.9%	47 0.7%	16 0.3%	11 0.5%	300 1.4%
5-19Y, DOM *, Ongoing	1 0%	0 0%	0 0%	1 0%	6 0%
5-19Y, DOM *, 1-7 days	12 0.2%	4 0.1%	0 0%	1 0%	22 0.1%
5-19Y, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, DOM *, Missing/NA	185 2.9%	47 0.7%	16 0.3%	11 0.5%	300 1.4%
5-19Y, MH in the last 3 months, Yes	0 0%	0 0%	0 0%	0 0%	2 0%
5-19Y, MH in the last 3 months, No	198 3.1%	51 0.8%	16 0.3%	13 0.5%	326 1.5%
20Y+, MT in past 14 days, Yes	1 0%	0 0%	0 0%	8 0.3%
20Y+, MT in past 14 days, No	86 1.3%	4 0.1%	1 0%	500 20.8%
20Y+, EDMT *, Ongoing	0 0%	0 0%	0 0%	1 0%
20Y+, EDMT *, 1-3 days	1 0%	0 0%	0 0%	5 0.2%
20Y+, EDMT *, ≥ 4days	0 0%	0 0%	0 0%	2 0.1%
20Y+, EDMT *, Missing/NA	86 1.3%	4 0.1%	1 0%	500 20.8%
20Y+, OM in past 14 days, Yes	5 0.1%	0 0%	0 0%	57 2.4%
20Y+, OM in past 14 days, No	82 1.3%	4 0.1%	1 0%	451 18.8%
20Y+, DOM *, Ongoing	1 0%	0 0%	0 0%	18 0.8%
20Y+, DOM *, 1-7 days	4 0.1%	0 0%	0 0%	36 1.5%
20Y+, DOM *, ≥ 8 days	0 0%	0 0%	0 0%	3 0.1%
20Y+, DOM *, Missing/NA	82 1.3%	4 0.1%	1 0%	451 18.8%
20Y+, MH in the last 3 months, Yes	0 0%	0 0%	0 0%	5 0.2%
20Y+, MH in the last 3 months, No	87 1.4%	4 0.1%	1 0%	503 21%

8. Secondary Outcome

Title	Mean Number of Days With Malaria Treatment at Survey 1
Description	The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the 14 day-period before the malaria treatment

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	24	13	6	14	401
6M-4Y, DMT	2.6 (1.02)	3.7 (1.70)	2.5 (0.71)	3.1 (0.67)	3.1 (1.45)
5-19Y, DMT	2.0 (0.82)	2.2 (0.98)	2.8 (0.50)	3.5 (0.71)	2.5 (1.09)
20+Y, DMT	1.0 (0.00)	2.6 (1.37)

9. Secondary Outcome

Title	Mean Number of Days With Malaria Treatment at Survey 2
Description	The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the 14 day-period before the malaria treatment

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	25	5	4	9	377
6M-4Y, DMT	2.8 (1.48)	5.7 (2.31)	3.5 (0.71)	2.0 (1.15)	3.1 (1.16)
5-19Y, DMT	2.8 (1.81)	3.5 (2.12)	3.0 (0.00)	2.5 (1.00)	2.5 (0.81)
20+Y, DMT	3.0 (0.00)	1.0 (0.00)	2.5 (1.37)

10. Secondary Outcome

Title	Mean Number of Days With Malaria Treatment at Survey 3
Description	The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the 14 day-period before the malaria treatment

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	28	17	4	6	352
6M-4Y, DMT	3.0 (0.71)	3.3 (1.07)	2.3 (1.15)	2.2 (1.10)	3.1 (1.08)
5-19Y, DMT	3.9 (2.88)	1.7 (1.15)	3.0 (0.00)	1.0 (0.00)	2.9 (1.27)
20+Y, DMT	1.4 (0.89)	5.0 (2.83)	2.3 (1.12)

11. Secondary Outcome

Title	Mean Number of Days With Malaria Treatment at Survey 4
Description	The mean and standard deviation of the number of days of malaria treatment (DMT) were calculated for the past 14 days period of treatment. The malaria treatment data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the 14 day-period before the malaria treatment

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and who have data available during the past 14 days period of Malaria treatment.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	6	1	1	1	64
6M-4Y, DMT	2.3 (1.15)	3.0 (0.00)	3.0 (0.00)	1.0 (0.00)	3.1 (0.59)
5-19Y, DMT	3.0 (0.00)	2.9 (0.38)
20+Y, DMT	1.0 (0.00)	3.3 (2.14)

12. Secondary Outcome

Title	Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 1
Description	Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	In the last 24 hours or at the survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, F 24h - Yes	71 1.1%	53 0.8%	21 0.3%	60 2.5%	361 1.7%
6M-4Y, F 24h - No	302 4.7%	117 1.8%	37 0.6%	59 2.5%	2119 9.8%
6M-4Y, F at V - Yes	26 0.4%	13 0.2%	7 0.1%	22 0.9%	79 0.4%
6M-4Y, F at V - No	347 5.4%	157 2.4%	51 0.8%	97 4%	2400 11.1%
6M-4Y, F at V - Missing/NA	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, F 24h - Yes	37 0.6%	25 0.4%	10 0.2%	24 1%	124 0.6%
5-19Y, F 24h - No	257 4%	46 0.7%	13 0.2%	34 1.4%	1043 4.8%
5-19Y, F at V - Yes	6 0.1%	5 0.1%	5 0.1%	17 0.7%	29 0.1%
5-19Y, F at V - No	288 4.5%	66 1%	18 0.3%	41 1.7%	1138 5.3%
20+Y, F 24h - Yes	30 0.5%	9 0.1%	2 0%	181 7.5%
20+Y, F 24h - No	89 1.4%	8 0.1%	9 0.1%	1260 52.5%
20+Y, F at V - Yes	3 0%	0 0%	1 0%	23 1%
20+Y, F at V - No	115 1.8%	17 0.3%	10 0.2%	1418 59.1%
20+Y, F at V - Missing/NA	1 0%	0 0%	0 0%	0 0%

13. Secondary Outcome

Title	Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 2
Description	Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	In the last 24 hours or at the survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, F 24h - Yes	41 0.6%	23 0.4%	15 0.2%	35 1.5%	357 1.7%
6M-4Y, F 24h - No	242 3.8%	125 1.9%	52 0.8%	41 1.7%	2266 10.5%
6M-4Y, F at V - Yes	26 0.4%	16 0.2%	15 0.2%	29 1.2%	98 0.5%
6M-4Y, F at V - No	257 4%	132 2.1%	52 0.8%	47 2%	2525 11.7%
5-19Y, F 24h - Yes	39 0.6%	11 0.2%	11 0.2%	13 0.5%	115 0.5%
5-19Y, F 24h - No	294 4.6%	60 0.9%	18 0.3%	23 1%	1043 4.8%
5-19Y, F at V - Yes	24 0.4%	4 0.1%	3 0%	8 0.3%	26 0.1%
5-19Y, F at V - No	309 4.8%	67 1%	26 0.4%	28 1.2%	1132 5.2%
20+Y, F 24h - Yes	14 0.2%	4 0.1%	3 0%	2 0.1%	169 0.8%
20+Y, F 24h - No	110 1.7%	6 0.1%	2 0%	5 0.2%	1272 5.9%
20+Y, F at V - Yes	10 0.2%	0 0%	0 0%	1 0%	36 0.2%
20+Y, F at V - No	114 1.8%	10 0.2%	5 0.1%	6 0.3%	1404 6.5%
20+Y, F at V - Missing/NA	0 0%	0 0%	0 0%	0 0%	1 0%

14. Secondary Outcome

Title	Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 3
Description	Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	In the last 24 hours or at the survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, F 24h - Yes	60 0.9%	44 0.7%	28 0.4%	44 1.8%	360 1.7%
6M-4Y, F 24h - No	219 3.4%	117 1.8%	46 0.7%	47 2%	2228 10.3%
6M-4Y, F at V - Yes	8 0.1%	16 0.2%	9 0.1%	22 0.9%	56 0.3%
6M-4Y, F at V - No	271 4.2%	145 2.3%	65 1%	69 2.9%	2532 11.7%
5-19Y, F 24h - Yes	54 0.8%	25 0.4%	4 0.1%	17 0.7%	92 0.4%
5-19Y, F 24h - No	287 4.5%	69 1.1%	9 0.1%	18 0.8%	1037 4.8%
5-19Y, F at V - Yes	11 0.2%	6 0.1%	1 0%	14 0.6%	21 0.1%
5-19Y, F at V - No	330 5.2%	87 1.4%	12 0.2%	21 0.9%	1107 5.1%
5-19Y, F at V - Missing/NA	0 0%	1 0%	0 0%	0 0%	1 0%
20+Y, F 24h - Yes	20 0.3%	4 0.1%	4 0.1%	1 0%	167 0.8%
20+Y, F 24h - No	151 2.4%	9 0.1%	1 0%	3 0.1%	1235 5.7%
20+Y, F at V - Yes	5 0.1%	0 0%	3 0%	1 0%	23 0.1%
20+Y, F at V - No	166 2.6%	13 0.2%	2 0%	3 0.1%	1378 6.4%
20+Y, F at V - Missing/NA	0 0%	0 0%	0 0%	0 0%	1 0%

15. Secondary Outcome

Title	Number of Subjects With Fever in the Last 24 Hours or at Visit During Survey 4
Description	Measured characteristics of fever were the following: Fever in the last 24 hours (F 24h) and Fever at visit (F at V). Note: Fever set to "Yes" if temperature recorded after axillary conversion was ≥ 37.5 degrees Celsius (°C). Missing/NA = Missing or Not Applicable. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	In the last 24 hours or at the survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, F 24h - Yes	39 0.6%	18 0.3%	5 0.1%	27 1.1%	115 0.5%
6M-4Y, F 24h - No	129 2%	85 1.3%	15 0.2%	27 1.1%	733 3.4%
6M-4Y, F at V - Yes	8 0.1%	8 0.1%	4 0.1%	18 0.8%	20 0.1%
6M-4Y, F at V - No	160 2.5%	95 1.5%	16 0.3%	36 1.5%	827 3.8%
6M-4Y, F at V - Missing/NA	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, F 24h - Yes	38 0.6%	8 0.1%	4 0.1%	4 0.2%	22 0.1%
5-19Y, F 24h - No	160 2.5%	43 0.7%	12 0.2%	9 0.4%	306 1.4%
5-19Y, F at V - Yes	5 0.1%	0 0%	2 0%	1 0%	4 0%
5-19Y, F at V - No	193 3%	51 0.8%	14 0.2%	12 0.5%	324 1.5%
20+Y, F 24h - Yes	11 0.2%	0 0%	0 0%	25 1%
20+Y, F 24h - No	76 1.2%	4 0.1%	1 0%	483 20.1%
20+Y, F at V - Yes	0 0%	0 0%	0 0%	3 0.1%
20+Y, F at V - No	87 1.4%	4 0.1%	1 0%	505 21%

16. Secondary Outcome

Title	Mean Number of Days With Fever at Survey 1
Description	The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	138	87	31	86	663
6M-4Y, DaFs	2.5 (2.18)	2.6 (2.23)	2.1 (1.42)	2.5 (4.13)	2.3 (1.77)
5-19Y, DaFs	2.2 (1.41)	2.2 (1.29)	2.7 (2.06)	1.7 (1.05)	2.3 (1.93)
20+Y, DaFs	2.3 (1.56)	2.3 (1.87)	2.5 (0.71)	2.9 (3.36)

17. Secondary Outcome

Title	Mean Number of Days With Fever at Survey 2
Description	The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	94	38	29	50	641
6M-4Y, DaFs	2.1 (1.35)	2.7 (1.99)	1.4 (0.51)	2.0 (1.46)	2.4 (1.76)
5-19Y, DaFs	2.5 (1.62)	2.6 (2.38)	2.5 (2.34)	2.1 (1.80)	2.1 (1.38)
20+Y, DaFs	4.0 (3.64)	2.0 (1.15)	2.0 (1.00)	4.0 (2.83)	3.2 (2.96)

18. Secondary Outcome

Title	Mean Number of Days With Fever at Survey 3
Description	The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	134	72	36	62	619
6M-4Y, DaFs	2.3 (1.90)	2.4 (1.95)	2.2 (1.33)	2.1 (1.37)	2.5 (1.80)
5-19Y, DaFs	2.3 (1.58)	2.8 (1.63)	2.5 (1.73)	1.8 (0.53)	2.7 (2.21)
20+Y, DaFs	3.0 (1.81)	2.8 (0.50)	3.8 (2.22)	3.0 (0.00)	3.3 (4.28)

19. Secondary Outcome

Title	Mean Number of Days With Fever at Survey 4
Description	The mean and standard deviation of the number of days ago with fever start (DaFs) were calculated for subjects having fever in the last 24 hours. Fever data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	During the survey period (approximatively 1 year)

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit and with fever reported in the last 24 hours.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	88	26	9	31	162
6M-4Y, DaFs	2.2 (1.05)	2.4 (2.43)	1.6 (0.89)	2.2 (1.64)	2.7 (1.88)
5-19Y, DaFs	2.0 (0.97)	3.8 (2.38)	1.5 (0.58)	2.0 (1.15)	2.1 (1.23)
20+Y, DaFs	2.5 (1.21)	3.2 (1.38)

20. Secondary Outcome

Title	Axillary Temperature at Visit in Survey 1
Description	The mean and standard deviation of the axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	785	258	81	188	5087
6M-4Y, A temp. at V	36.65 (0.521)	36.64 (0.623)	36.72 (0.782)	37.04 (0.803)	36.55 (0.522)
5-19Y, A temp. at V	36.56 (0.469)	36.70 (0.597)	37.07 (0.853)	37.29 (0.928)	36.63 (0.496)
20+Y, A temp. at V	36.55 (0.459)	36.70 (0.387)	36.82 (0.462)	36.60 (0.478)

21. Secondary Outcome

Title	Axillary Temperature at Visit in Survey 2
Description	The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5221
6M-4Y, A temp. at V	36.69 (0.574)	36.75 (0.628)	36.86 (0.725)	37.41 (1.201)	36.60 (0.479)
5-19Y, A temp. at V	36.70 (0.522)	36.76 (0.507)	36.76 (0.773)	37.36 (0.949)	36.66 (0.447)
20+Y, A temp. at V	36.70 (0.478)	36.75 (0.375)	36.64 (0.559)	37.09 (0.713)	36.67 (0.430)

22. Secondary Outcome

Title	Axillary Temperature at Visit in Survey 3
Description	The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	267	92	130	5117
6M-4Y, A temp. at V	36.47 (0.517)	36.66 (0.652)	36.68 (0.701)	36.97 (0.951)	36.54 (0.496)
5-19Y, A temp. at V	36.56 (0.551)	36.66 (0.571)	36.61 (0.475)	37.45 (1.117)	36.59 (0.462)
20+Y, A temp. at V	36.44 (0.515)	36.42 (0.409)	37.54 (1.135)	37.18 (0.727)	36.55 (0.493)

23. Secondary Outcome

Title	Axillary Temperature at Visit in Survey 4
Description	The mean and standard deviation of axillary temperature at visit (A temp. at V) were calculated. Axillary temperature data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1683
6M-4Y, A temp. at V	36.51 (0.508)	36.51 (0.535)	36.95 (0.927)	37.16 (1.187)	36.40 (0.492)
5-19Y, A temp. at V	36.53 (0.510)	36.55 (0.379)	36.53 (0.570)	36.61 (0.431)	36.38 (0.430)
20+Y, A temp. at V	36.42 (0.444)	36.68 (0.206)	36.50 (0.000)	36.39 (0.457)

24. Secondary Outcome

Title	Number of Subjects Living in the Same House at Survey 1
Description	The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, PLSPH/PES, <3/1	34 0.5%	13 0.2%	3 0%	2 0.1%	78 0.4%
6M-4Y, PLSPH/PES, 4-5/1	32 0.5%	15 0.2%	1 0%	2 0.1%	146 0.7%
6M-4Y, PLSPH/PES, >5/1	20 0.3%	10 0.2%	0 0%	3 0.1%	123 0.6%
6M-4Y, PLSPH/PES, <3/2	46 0.7%	14 0.2%	6 0.1%	14 0.6%	280 1.3%
6M-4Y, PLSPH/PES, 4-5/2	106 1.7%	49 0.8%	13 0.2%	36 1.5%	737 3.4%
6M-4Y, PLSPH/PES, >5/2	119 1.9%	59 0.9%	28 0.4%	59 2.5%	1038 4.8%
6M-4Y, PLSPH/PES, <3/3	1 0%	0 0%	0 0%	0 0%	3 0%
6M-4Y, PLSPH/PES, 4-5/3	1 0%	1 0%	1 0%	1 0%	19 0.1%
6M-4Y, PLSPH/PES, >5/3	13 0.2%	7 0.1%	4 0.1%	1 0%	45 0.2%
6M-4Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	1 0%	0 0%	1 0%
6M-4Y, PLSPH/PES, >5/>3	1 0%	2 0%	1 0%	1 0%	9 0%
6M-4Y, Missing	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, PLSPH/PES, <3/1	20 0.3%	6 0.1%	0 0%	0 0%	28 0.1%
5-19Y, PLSPH/PES, 4-5/1	14 0.2%	2 0%	1 0%	1 0%	17 0.1%
5-19Y, PLSPH/PES, >5/1	8 0.1%	3 0%	1 0%	0 0%	37 0.2%
5-19Y, PLSPH/PES, <3/2	19 0.3%	4 0.1%	1 0%	5 0.2%	75 0.3%
5-19Y, PLSPH/PES, 4-5/2	76 1.2%	13 0.2%	9 0.1%	17 0.7%	357 1.7%
5-19Y, PLSPH/PES, >5/2	111 1.7%	38 0.6%	10 0.2%	34 1.4%	560 2.6%
5-19Y, PLSPH/PES, <3/3	0 0%	1 0%	0 0%	0 0%	2 0%
5-19Y, PLSPH/PES, 4-5/3	10 0.2%	1 0%	0 0%	0 0%	14 0.1%
5-19Y, PLSPH/PES, >5/3	25 0.4%	2 0%	1 0%	1 0%	59 0.3%
5-19Y, PLSPH/PES, 4-5/>3	1 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, PLSPH/PES, >5/>3	10 0.2%	1 0%	0 0%	0 0%	17 0.1%
5-19Y, Missing	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, PLSPH/PES, <3/1	3 0%	0 0%	0 0%	49 2%
20+Y, PLSPH/PES, 4-5/1	1 0%	0 0%	0 0%	16 0.7%
20+Y, PLSPH/PES, >5/1	6 0.1%	1 0%	0 0%	26 1.1%
20+Y, PLSPH/PES, <3/2	22 0.3%	2 0%	2 0%	234 9.8%
20+Y, PLSPH/PES, 4-5/2	40 0.6%	7 0.1%	3 0%	449 18.7%
20+Y, PLSPH/PES, >5/2	33 0.5%	7 0.1%	6 0.1%	575 24%
20+Y, PLSPH/PES, <3/3	0 0%	0 0%	0 0%	2 0.1%
20+Y, PLSPH/PES, 4-5/3	3 0%	0 0%	0 0%	18 0.8%
20+Y, PLSPH/PES, >5/3	10 0.2%	0 0%	0 0%	51 2.1%
20+Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	1 0%
20+Y, PLSPH/PES, >5/>3	1 0%	0 0%	0 0%	18 0.8%
20+Y, Missing	0 0%	0 0%	0 0%	2 0.1%

25. Secondary Outcome

Title	Number of Subjects Living in the Same House at Survey 2
Description	The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, PLSPH/PES, <3/1	27 0.4%	18 0.3%	8 0.1%	2 0.1%	59 0.3%
6M-4Y, PLSPH/PES, 4-5/1	33 0.5%	18 0.3%	8 0.1%	3 0.1%	112 0.5%
6M-4Y, PLSPH/PES, >5/1	13 0.2%	9 0.1%	3 0%	4 0.2%	84 0.4%
6M-4Y, PLSPH/PES, <3/2	37 0.6%	21 0.3%	8 0.1%	14 0.6%	306 1.4%
6M-4Y, PLSPH/PES, 4-5/2	93 1.5%	48 0.7%	17 0.3%	24 1%	964 4.5%
6M-4Y, PLSPH/PES, >5/2	76 1.2%	32 0.5%	19 0.3%	27 1.1%	1059 4.9%
6M-4Y, PLSPH/PES, <3/3	1 0%	0 0%	0 0%	0 0%	2 0%
6M-4Y, PLSPH/PES, 4-5/3	0 0%	0 0%	0 0%	0 0%	11 0.1%
6M-4Y, PLSPH/PES, >5/3	3 0%	1 0%	4 0.1%	2 0.1%	24 0.1%
6M-4Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	2 0%
6M-4Y, PLSPH/PES, >5/>3	0 0%	1 0%	0 0%	0 0%	0 0%
5-19Y, PLSPH/PES, <3/1	34 0.5%	3 0%	1 0%	3 0.1%	23 0.1%
5-19Y, PLSPH/PES, 4-5/1	30 0.5%	13 0.2%	2 0%	0 0%	20 0.1%
5-19Y, PLSPH/PES, >5/1	16 0.2%	3 0%	0 0%	0 0%	38 0.2%
5-19Y, PLSPH/PES, <3/2	30 0.5%	3 0%	0 0%	2 0.1%	69 0.3%
5-19Y, PLSPH/PES, 4-5/2	98 1.5%	17 0.3%	10 0.2%	13 0.5%	426 2%
5-19Y, PLSPH/PES, >5/2	105 1.6%	28 0.4%	15 0.2%	17 0.7%	548 2.5%
5-19Y, PLSPH/PES, <3/3	2 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, PLSPH/PES, 4-5/3	4 0.1%	0 0%	0 0%	0 0%	9 0%
5-19Y, PLSPH/PES, >5/3	14 0.2%	4 0.1%	1 0%	1 0%	20 0.1%
5-19Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	4 0%
5-19Y, PLSPH/PES, >5/>3	0 0%	0 0%	0 0%	0 0%	0 0%
20+Y, PLSPH-PES, <3/1	14 0.2%	0 0%	0 0%	0 0%	40 0.2%
20+Y, PLSPH/PES, 4-5/1	8 0.1%	0 0%	0 0%	0 0%	26 0.1%
20+Y, PLSPH/PES, >5/1	5 0.1%	0 0%	1 0%	0 0%	51 0.2%
20+Y, PLSPH/PES, <3/2	34 0.5%	2 0%	1 0%	2 0.1%	253 1.2%
20+Y, PLSPH/PES, 4-5/2	39 0.6%	3 0%	0 0%	2 0.1%	553 2.6%
20+Y, PLSPH/PES, >5/2	21 0.3%	5 0.1%	3 0%	3 0.1%	476 2.2%
20+Y, PLSPH/PES, <3/3	0 0%	0 0%	0 0%	0 0%	3 0%
20+Y, PLSPH/PES, 4-5/3	0 0%	0 0%	0 0%	0 0%	9 0%
20+Y, PLSPH/PES, >5/3	3 0%	0 0%	0 0%	0 0%	25 0.1%
20+Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	2 0%
20+Y, PLSPH/PES, >5/>3	0 0%	0 0%	0 0%	0 0%	3 0%

26. Secondary Outcome

Title	Number of Subjects Living in the Same House at Survey 3
Description	The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, PLSPH/PES, <3/1	31 0.5%	16 0.2%	7 0.1%	11 0.5%	63 0.3%
6M-4Y, PLSPH/PES, 4-5/1	31 0.5%	26 0.4%	8 0.1%	11 0.5%	94 0.4%
6M-4Y, PLSPH/PES, >5/1	15 0.2%	10 0.2%	6 0.1%	2 0.1%	94 0.4%
6M-4Y, PLSPH/PES, <3/2	43 0.7%	24 0.4%	13 0.2%	17 0.7%	340 1.6%
6M-4Y, PLSPH/PES, 4-5/2	76 1.2%	30 0.5%	19 0.3%	22 0.9%	973 4.5%
6M-4Y, PLSPH/PES, >5/2	75 1.2%	44 0.7%	19 0.3%	26 1.1%	984 4.6%
6M-4Y, PLSPH/PES, <3/3	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, PLSPH/PES, 4-5/3	2 0%	0 0%	1 0%	0 0%	11 0.1%
6M-4Y, PLSPH/PES, >5/3	6 0.1%	11 0.2%	1 0%	2 0.1%	29 0.1%
6M-4Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, PLSPH/PES, >5/>3	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, PLSPH/PES, <3/1	40 0.6%	9 0.1%	1 0%	1 0%	24 0.1%
5-19Y, PLSPH/PES, 4-5/1	32 0.5%	8 0.1%	0 0%	1 0%	23 0.1%
5-19Y, PLSPH/PES, >5/1	31 0.5%	1 0%	0 0%	3 0.1%	42 0.2%
5-19Y, PLSPH/PES, <3/2	24 0.4%	13 0.2%	0 0%	2 0.1%	88 0.4%
5-19Y, PLSPH/PES, 4-5/2	74 1.2%	25 0.4%	5 0.1%	13 0.5%	421 1.9%
5-19Y, PLSPH/PES, >5/2	103 1.6%	36 0.6%	7 0.1%	15 0.6%	507 2.3%
5-19Y, PLSPH/PES, <3/3	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, PLSPH/PES, 4-5/3	7 0.1%	0 0%	0 0%	0 0%	7 0%
5-19Y, PLSPH/PES, >5/3	30 0.5%	2 0%	0 0%	0 0%	17 0.1%
5-19Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, PLSPH/PES, >5/>3	0 0%	0 0%	0 0%	0 0%	0 0%
20+Y, PLSPH/PES, <3/1	18 0.3%	0 0%	0 0%	0 0%	40 0.2%
20+Y, PLSPH/PES, 4-5/1	7 0.1%	0 0%	0 0%	0 0%	27 0.1%
20+Y, PLSPH/PES, >5/1	5 0.1%	0 0%	0 0%	0 0%	33 0.2%
20+Y, PLSPH/PES, <3/2	43 0.7%	3 0%	0 0%	1 0%	273 1.3%
20+Y, PLSPH/PES, 4-5/2	57 0.9%	4 0.1%	3 0%	0 0%	516 2.4%
20+Y, PLSPH/PES, >5/2	28 0.4%	6 0.1%	2 0%	3 0.1%	463 2.1%
20+Y, PLSPH/PES, <3/3	0 0%	0 0%	0 0%	0 0%	0 0%
20+Y, PLSPH/PES, 4-5/3	0 0%	0 0%	0 0%	0 0%	14 0.1%
20+Y, PLSPH/PES, >5/3	13 0.2%	0 0%	0 0%	0 0%	36 0.2%
20+Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	0 0%
20+Y, PLSPH/PES, >5/>3	0 0%	0 0%	0 0%	0 0%	0 0%

27. Secondary Outcome

Title	Number of Subjects Living in the Same House at Survey 4
Description	The malaria prevention and risk factors characteristics were: Number of persons living in the same part of the house (PLSPH) among persons enrolled in the study (PES), in the following combinations: < y/x (less than [<] y PLSPH among x PES), y-z/x (y to z PLSPH among x PES), > z/x (more than [>] z PLSPH among x PES), y-z/> x (y to z PLSPH among more than [>] x PES), > z/> x (more than [>] z PLSPH among more than [>] x PES, or missing information). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, PLSPH/PES, <3/1	28 0.4%	21 0.3%	2 0%	7 0.3%	42 0.2%
6M-4Y, PLSPH/PES, 4-5/1	24 0.4%	14 0.2%	4 0.1%	5 0.2%	74 0.3%
6M-4Y, PLSPH/PES, >5/1	18 0.3%	7 0.1%	1 0%	5 0.2%	59 0.3%
6M-4Y, PLSPH/PES, <3/2	27 0.4%	18 0.3%	3 0%	10 0.4%	74 0.3%
6M-4Y, PLSPH/PES, 4-5/2	30 0.5%	23 0.4%	3 0%	13 0.5%	184 0.9%
6M-4Y, PLSPH/PES, >5/2	25 0.4%	12 0.2%	4 0.1%	12 0.5%	338 1.6%
6M-4Y, PLSPH-PES, <3/3	0 0%	0 0%	1 0%	0 0%	1 0%
6M-4Y, PLSPH/PES, 4-5/3	1 0%	1 0%	0 0%	1 0%	9 0%
6M-4Y, PLSPH/PES, >5/3	14 0.2%	7 0.1%	2 0%	1 0%	62 0.3%
6M-4Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	1 0%
6M-4Y, PLSPH/PES, >5/>3	1 0%	0 0%	0 0%	0 0%	4 0%
5-19Y, PLSPH/PES, <3/1	36 0.6%	5 0.1%	2 0%	2 0.1%	17 0.1%
5-19Y, PLSPH/PES, 4-5/1	35 0.5%	11 0.2%	1 0%	2 0.1%	23 0.1%
5-19Y, PLSPH/PES, >5/1	4 0.1%	2 0%	2 0%	1 0%	7 0%
5-19Y, PLSPH/PES, <3/2	13 0.2%	5 0.1%	2 0%	0 0%	10 0%
5-19Y, PLSPH/PES, 4-5/2	27 0.4%	8 0.1%	3 0%	3 0.1%	65 0.3%
5-19Y, PLSPH/PES, >5/2	31 0.5%	10 0.2%	3 0%	4 0.2%	149 0.7%
5-19Y, PLSPH/PES, <3/3	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, PLSPH/PES, 4-5/3	5 0.1%	1 0%	0 0%	0 0%	12 0.1%
5-19Y, PLSPH/PES, >5/3	42 0.7%	9 0.1%	3 0%	1 0%	38 0.2%
5-19Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	0 0%	2 0%
5-19Y, PLSPH/PES, >5/>3	5 0.1%	0 0%	0 0%	0 0%	5 0%
20+Y, PLSPH/PES, <3/1	4 0.1%	0 0%	0 0%	20 0.8%
20+Y, PLSPH/PES, 4-5/1	4 0.1%	0 0%	0 0%	8 0.3%
20+Y, PLSPH/PES, >5/1	1 0%	0 0%	0 0%	10 0.4%
20+Y, PLSPH/PES, <3/2	23 0.4%	0 0%	0 0%	81 3.4%
20+Y, PLSPH/PES, 4-5/2	26 0.4%	2 0%	0 0%	119 5%
20+Y, PLSPH/PES, >5/2	15 0.2%	1 0%	0 0%	191 8%
20+Y, PLSPH/PES, <3/3	1 0%	0 0%	0 0%	3 0.1%
20+Y, PLSPH/PES, 4-5/3	2 0%	0 0%	1 0%	3 0.1%
20+Y, PLSPH/PES, >5/3	11 0.2%	1 0%	0 0%	67 2.8%
20+Y, PLSPH/PES, 4-5/>3	0 0%	0 0%	0 0%	1 0%
20+Y, PLSPH/PES, >5/>3	0 0%	0 0%	0 0%	5 0.2%

28. Secondary Outcome

Title	Mean Number of Subjects Living in the Same House at Survey 1
Description	The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, PLSPH	6.4 (4.83)	6.3 (4.23)	6.5 (3.98)	5.8 (2.14)	6.5 (4.28)
5-19Y, PLSPH	6.9 (4.55)	6.6 (3.53)	5.9 (1.91)	6.5 (3.04)	7.1 (4.69)
20+Y, PLSPH	6.1 (4.15)	7.4 (5.21)	6.2 (2.99)	6.3 (4.24)

29. Secondary Outcome

Title	Mean Number of Subjects Living in the Same House at Survey 2
Description	The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, PLSPH	5.1 (2.90)	5.0 (2.17)	5.1 (2.34)	5.4 (2.62)	5.8 (2.66)
5-19Y, PLSPH	5.5 (2.64)	6.1 (2.78)	5.9 (1.89)	5.9 (2.81)	6.2 (2.78)
20+Y, PLSPH	4.7 (3.35)	6.5 (3.24)	7.8 (3.27)	5.3 (2.56)	5.4 (2.64)

30. Secondary Outcome

Title	Mean Number of Subjects Living in the Same House at Survey 3
Description	The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, PLSPH	5.1 (2.73)	5.4 (2.74)	5.1 (3.40)	5.0 (2.43)	5.6 (2.48)
5-19Y, PLSPH	5.9 (3.25)	5.1 (2.04)	5.5 (1.85)	5.8 (2.06)	6.0 (2.42)
20+Y, PLSPH	4.5 (2.16)	5.9 (3.23)	5.4 (1.14)	6.5 (2.89)	5.4 (2.77)

31. Secondary Outcome

Title	Mean Number of Subjects Living in the Same House at Survey 4
Description	The malaria prevention and risk factors characteristics were the following: the mean and standard deviation of the number of persons living in the same part of the house (PLSPH). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, PLSPH	5.4 (3.12)	5.1 (3.73)	5.5 (3.50)	5.2 (3.24)	6.6 (3.33)
5-19Y, PLSPH	6.5 (4.55)	6.1 (3.95)	6.3 (3.13)	6.8 (4.28)	7.3 (3.70)
20+Y, PLSPH	5.0 (2.94)	6.3 (2.22)	5.0 (0.00)	6.6 (3.96)

32. Secondary Outcome

Title	Number of Subjects by Localisation and Type of Location at Survey 1
Description	The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural or missing) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants or missing type of location). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, rural	309 4.8%	136 2.1%	45 0.7%	106 4.4%	1415 6.5%
6M-4Y, urban	39 0.6%	22 0.3%	10 0.2%	11 0.5%	803 3.7%
6M-4Y, semi-rural	25 0.4%	12 0.2%	3 0%	2 0.1%	262 1.2%
6M-4Y, missing - localisation	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, large city	18 0.3%	14 0.2%	7 0.1%	7 0.3%	355 1.6%
6M-4Y, small city	0 0%	0 0%	0 0%	0 0%	18 0.1%
6M-4Y, town	44 0.7%	16 0.2%	5 0.1%	6 0.3%	644 3%
6M-4Y, countryside	311 4.9%	140 2.2%	46 0.7%	106 4.4%	1463 6.8%
5-19Y, rural	225 3.5%	55 0.9%	16 0.3%	51 2.1%	688 3.2%
5-19Y, urban	50 0.8%	13 0.2%	4 0.1%	5 0.2%	350 1.6%
5-19Y, semi-rural	19 0.3%	3 0%	3 0%	2 0.1%	128 0.6%
5-19Y, missing - localisation	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, large city	25 0.4%	5 0.1%	4 0.1%	4 0.2%	162 0.7%
5-19Y, small city	1 0%	0 0%	0 0%	0 0%	7 0%
5-19Y, town	43 0.7%	11 0.2%	2 0%	3 0.1%	282 1.3%
5-19Y, countryside	225 3.5%	55 0.9%	17 0.3%	51 2.1%	715 3.3%
5-19Y, missing - type of localisation	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, rural	89 1.4%	12 0.2%	10 0.2%	923 38.5%
20+Y, urban	26 0.4%	3 0%	0 0%	370 15.4%
20+Y, semi-rural	4 0.1%	2 0%	1 0%	147 6.1%
20+Y, missing - localisation	0 0%	0 0%	0 0%	1 0%
20+Y, large city	16 0.2%	3 0%	0 0%	181 7.5%
20+Y, small city	0 0%	0 0%	0 0%	9 0.4%
20+Y, town	14 0.2%	2 0%	1 0%	299 12.5%
20+Y, countryside	89 1.4%	12 0.2%	10 0.2%	951 39.6%
20+Y, missing - type of localisation	0 0%	0 0%	0 0%	1 0%

33. Secondary Outcome

Title	Number of Subjects by Localisation and Type of Location at Survey 2
Description	The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, rural	212 3.3%	120 1.9%	51 0.8%	60 2.5%	1377 6.4%
6M-4Y, urban	44 0.7%	16 0.2%	14 0.2%	15 0.6%	995 4.6%
6M-4Y, semi-rural	27 0.4%	12 0.2%	2 0%	1 0%	251 1.2%
6M-4Y, large city	10 0.2%	4 0.1%	5 0.1%	6 0.3%	374 1.7%
6M-4Y, small city	0 0%	0 0%	0 0%	0 0%	6 0%
6M-4Y, town	34 0.5%	12 0.2%	9 0.1%	9 0.4%	632 2.9%
6M-4Y, countryside	239 3.7%	132 2.1%	53 0.8%	61 2.5%	1611 7.5%
5-19Y, rural	237 3.7%	48 0.7%	17 0.3%	25 1%	583 2.7%
5-19Y, urban	72 1.1%	22 0.3%	11 0.2%	10 0.4%	472 2.2%
5-19Y, semi-rural	24 0.4%	1 0%	1 0%	1 0%	103 0.5%
5-19Y, large city	15 0.2%	5 0.1%	2 0%	7 0.3%	172 0.8%
5-19Y, small city	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, town	57 0.9%	17 0.3%	9 0.1%	3 0.1%	305 1.4%
5-19Y, countryside	261 4.1%	49 0.8%	18 0.3%	26 1.1%	680 3.1%
20+Y, rural	94 1.5%	6 0.1%	2 0%	6 0.3%	769 3.6%
20+Y, urban	26 0.4%	4 0.1%	3 0%	1 0%	515 2.4%
20+Y, semi-rural	4 0.1%	0 0%	0 0%	0 0%	157 0.7%
20+Y, large city	6 0.1%	2 0%	0 0%	1 0%	191 0.9%
20+Y, small city	0 0%	0 0%	0 0%	0 0%	5 0%
20+Y, town	20 0.3%	2 0%	3 0%	0 0%	330 1.5%
20+Y, countryside	98 1.5%	6 0.1%	2 0%	6 0.3%	915 4.2%

34. Secondary Outcome

Title	Number of Subjects by Localisation and Type of Location at Survey 3
Description	The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, rural	234 3.7%	146 2.3%	65 1%	82 3.4%	1531 7.1%
6M-4Y, urban	30 0.5%	11 0.2%	5 0.1%	5 0.2%	881 4.1%
6M-4Y, semi-rural	15 0.2%	4 0.1%	4 0.1%	4 0.2%	176 0.8%
6M-4Y, large city	7 0.1%	3 0%	1 0%	3 0.1%	386 1.8%
6M-4Y, small city	0 0%	0 0%	0 0%	0 0%	2 0%
6M-4Y, town	23 0.4%	9 0.1%	4 0.1%	2 0.1%	541 2.5%
6M-4Y, countryside	249 3.9%	149 2.3%	69 1.1%	86 3.6%	1659 7.7%
5-19Y, rural	283 4.4%	78 1.2%	9 0.1%	28 1.2%	645 3%
5-19Y, urban	42 0.7%	12 0.2%	4 0.1%	7 0.3%	404 1.9%
5-19Y, semi-rural	16 0.2%	4 0.1%	0 0%	0 0%	80 0.4%
5-19Y, large city	12 0.2%	2 0%	2 0%	2 0.1%	182 0.8%
5-19Y, small city	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, town	30 0.5%	10 0.2%	2 0%	5 0.2%	241 1.1%
5-19Y, countryside	299 4.7%	82 1.3%	9 0.1%	28 1.2%	705 3.3%
20+Y, rural	147 2.3%	8 0.1%	5 0.1%	3 0.1%	868 4%
20+Y, urban	23 0.4%	3 0%	0 0%	1 0%	430 2%
20+Y, semi-rural	1 0%	2 0%	0 0%	0 0%	104 0.5%
20+Y, large city	15 0.2%	0 0%	0 0%	0 0%	185 0.9%
20+Y, small city	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, town	8 0.1%	3 0%	0 0%	1 0%	273 1.3%
20+Y, countryside	148 2.3%	10 0.2%	5 0.1%	3 0.1%	943 4.4%

35. Secondary Outcome

Title	Number of Subjects by Localisation and Type of Location at Survey 4
Description	The malaria prevention and risk factors characteristics were the following: localisation categories (i.e.: rural, urban, semi-rural) and Type of Location (i.e.: Large city: >1 million habitants; Small city: >50000 & < 1 million habitants; Town: > 10000 and < 50000 habitants; Countryside: < 10000 habitants). Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, rural	153 2.4%	102 1.6%	20 0.3%	53 2.2%	536 2.5%
6M-4Y, urban	15 0.2%	1 0%	0 0%	1 0%	312 1.4%
6M-4Y, semi-rural	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, large city	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, small city	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, town	15 0.2%	1 0%	0 0%	1 0%	311 1.4%
6M-4Y, countryside	153 2.4%	102 1.6%	20 0.3%	53 2.2%	537 2.5%
5-19Y, rural	184 2.9%	49 0.8%	14 0.2%	11 0.5%	186 0.9%
5-19Y, urban	14 0.2%	2 0%	2 0%	2 0.1%	142 0.7%
5-19Y, semi-rural	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, large city	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, small city	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, town	14 0.2%	2 0%	2 0%	2 0.1%	141 0.7%
5-19Y, countryside	184 2.9%	49 0.8%	14 0.2%	11 0.5%	187 0.9%
20+Y, rural	85 1.3%	4 0.1%	1 0%	352 14.7%
20+Y, urban	2 0%	0 0%	0 0%	156 6.5%
20+Y, semi-rural	0 0%	0 0%	0 0%	0 0%
20+Y, large city	0 0%	0 0%	0 0%	0 0%
20+Y, small city	0 0%	0 0%	0 0%	0 0%
20+Y, town	2 0%	0 0%	0 0%	155 6.5%
20+Y, countryside	85 1.3%	4 0.1%	1 0%	353 14.7%

36. Secondary Outcome

Title	Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 1
Description	The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other and missing. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, parquet polished wood, vinyl or asphalt strips, ceramic tiles, cement, carpet, missing. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, MHCM walls - mud	97 1.5%	62 1%	34 0.5%	84 3.5%	869 4%
6M-4Y, MHCM walls - brick	190 3%	76 1.2%	12 0.2%	12 0.5%	504 2.3%
6M-4Y, MHCM walls - cement/plaster	41 0.6%	16 0.2%	7 0.1%	11 0.5%	383 1.8%
6M-4Y, MHCM walls - cement/paint	29 0.5%	12 0.2%	5 0.1%	11 0.5%	408 1.9%
6M-4Y, MHCM walls - other	16 0.2%	4 0.1%	0 0%	1 0%	316 1.5%
6M-4Y, MHCM floor - natural floor	197 3.1%	100 1.6%	42 0.7%	83 3.5%	1079 5%
6M-4Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	3 0%
6M-4Y, MHCM floor - parquet polished wood	0 0%	0 0%	0 0%	0 0%	2 0%
6M-4Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	0 0%	4 0%
6M-4Y, MHCM floor - ceramic tiles	0 0%	1 0%	0 0%	0 0%	30 0.1%
6M-4Y, MHCM floor - cement	170 2.7%	69 1.1%	16 0.3%	33 1.4%	1309 6.1%
6M-4Y, MHCM floor - carpet	6 0.1%	0 0%	0 0%	3 0.1%	53 0.2%
5-19Y, MHCM walls - mud	89 1.4%	29 0.5%	13 0.2%	48 2%	424 2%
5-19Y, MHCM walls - brick	119 1.9%	23 0.4%	3 0%	4 0.2%	223 1%
5-19Y, MHCM walls - cement/plaster	43 0.7%	8 0.1%	4 0.1%	5 0.2%	168 0.8%
5-19Y, MHCM walls - cement/paint	30 0.5%	4 0.1%	3 0%	1 0%	186 0.9%
5-19Y, MHCM walls - other	13 0.2%	7 0.1%	0 0%	0 0%	165 0.8%
5-19Y, MHCM walls - missing	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM floor - natural floor	146 2.3%	46 0.7%	12 0.2%	48 2%	511 2.4%
5-19Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM floor - parquet polished wood	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	0 0%	2 0%
5-19Y, MHCM floor - ceramic tiles	0 0%	1 0%	0 0%	0 0%	14 0.1%
5-19Y, MHCM floor - cement	146 2.3%	24 0.4%	11 0.2%	10 0.4%	607 2.8%
5-19Y, MHCM floor - carpet	2 0%	0 0%	0 0%	0 0%	30 0.1%
5-19Y, MHCM floor - missing	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM walls - mud	43 0.7%	7 0.1%	9 0.1%	548 22.8%
20+Y, MHCM walls - brick	43 0.7%	2 0%	0 0%	337 14%
20+Y, MHCM walls - cement/plaster	12 0.2%	5 0.1%	1 0%	192 8%
20+Y, MHCM walls - cement/paint	16 0.2%	3 0%	0 0%	217 9%
20+Y, MHCM walls - other	5 0.1%	0 0%	1 0%	146 6.1%
20+Y, MHCM walls - missing	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM floor - natural floor	64 1%	5 0.1%	8 0.1%	690 28.8%
20+Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	2 0.1%
20+Y, MHCM floor - parquet polished wood	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	2 0.1%
20+Y, MHCM floor - ceramic tiles	0 0%	0 0%	0 0%	13 0.5%
20+Y, MHCM floor - cement	55 0.9%	11 0.2%	3 0%	705 29.4%
20+Y, MHCM floor - carpet	0 0%	1 0%	0 0%	27 1.1%
20+Y, MHCM floor - missing	0 0%	0 0%	0 0%	1 0%

37. Secondary Outcome

Title	Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 2
Description	The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, parquet polished wood, vinyl or asphalt strips, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, MHCM walls - mud	49 0.8%	30 0.5%	15 0.2%	29 1.2%	1010 4.7%
6M-4Y, MHCM walls - brick	163 2.5%	81 1.3%	34 0.5%	31 1.3%	458 2.1%
6M-4Y, MHCM walls - cement/plaster	33 0.5%	14 0.2%	8 0.1%	8 0.3%	472 2.2%
6M-4Y, MHCM walls - cement/paint	32 0.5%	15 0.2%	4 0.1%	2 0.1%	393 1.8%
6M-4Y, MHCM walls - other	6 0.1%	8 0.1%	6 0.1%	6 0.3%	290 1.3%
6M-4Y, MHCM floor - natural floor	194 3%	97 1.5%	45 0.7%	53 2.2%	1145 5.3%
6M-4Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	2 0%
6M-4Y, MHCM floor - parquet polished wood	0 0%	0 0%	1 0%	0 0%	6 0%
6M-4Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	0 0%	15 0.1%
6M-4Y, MHCM floor - ceramic tiles	0 0%	1 0%	0 0%	1 0%	40 0.2%
6M-4Y, MHCM floor - cement	84 1.3%	50 0.8%	20 0.3%	22 0.9%	1357 6.3%
6M-4Y, MHCM floor - carpet	5 0.1%	0 0%	1 0%	0 0%	58 0.3%
5-19Y, MHCM walls - mud	79 1.2%	20 0.3%	11 0.2%	21 0.9%	445 2.1%
5-19Y, MHCM walls - brick	155 2.4%	26 0.4%	11 0.2%	7 0.3%	191 0.9%
5-19Y, MHCM walls - cement/plaster	51 0.8%	15 0.2%	2 0%	4 0.2%	207 1%
5-19Y, MHCM walls - cement/paint	34 0.5%	5 0.1%	1 0%	0 0%	182 0.8%
5-19Y, MHCM walls - other	14 0.2%	5 0.1%	4 0.1%	4 0.2%	133 0.6%
5-19Y, MHCM floor - natural floor	207 3.2%	42 0.7%	17 0.3%	26 1.1%	508 2.3%
5-19Y, MHCM floor - rudimentary floor	1 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, MHCM floor - parquet polished wood	0 0%	0 0%	1 0%	0 0%	5 0%
5-19Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	0 0%	10 0%
5-19Y, MHCM floor - ceramic tiles	0 0%	0 0%	0 0%	0 0%	26 0.1%
5-19Y, MHCM floor - cement	117 1.8%	29 0.5%	11 0.2%	9 0.4%	587 2.7%
5-19Y, MHCM floor - carpet	8 0.1%	0 0%	0 0%	1 0%	22 0.1%
20+Y, MHCM walls - mud	26 0.4%	5 0.1%	1 0%	5 0.2%	520 2.4%
20+Y, MHCM walls - brick	69 1.1%	2 0%	0 0%	0 0%	302 1.4%
20+Y, MHCM walls - cement/plaster	7 0.1%	0 0%	1 0%	1 0%	258 1.2%
20+Y, MHCM walls - cement/paint	15 0.2%	0 0%	0 0%	0 0%	215 1%
20+Y, MHCM walls - other	7 0.1%	3 0%	3 0%	1 0%	146 0.7%
20+Y, MHCM floor - natural floor	88 1.4%	7 0.1%	2 0%	5 0.2%	653 3%
20+Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM floor - parquet polished wood	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	1 0%	0 0%	4 0%
20+Y, MHCM floor - ceramic tiles	1 0%	0 0%	0 0%	0 0%	15 0.1%
20+Y, MHCM floor - cement	34 0.5%	3 0%	2 0%	2 0.1%	732 3.4%
20+Y, MHCM floor - carpet	1 0%	0 0%	0 0%	0 0%	35 0.2%

38. Secondary Outcome

Title	Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 3
Description	The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, MHCM walls - mud	65 1%	42 0.7%	19 0.3%	33 1.4%	969 4.5%
6M-4Y, MHCM walls - brick	143 2.2%	91 1.4%	41 0.6%	43 1.8%	485 2.2%
6M-4Y, MHCM walls - cement/plaster	23 0.4%	10 0.2%	10 0.2%	5 0.2%	350 1.6%
6M-4Y, MHCM walls - cement/paint	28 0.4%	12 0.2%	3 0%	5 0.2%	464 2.1%
6M-4Y, MHCM walls - other	20 0.3%	6 0.1%	1 0%	5 0.2%	320 1.5%
6M-4Y, MHCM floor - natural floor	188 2.9%	111 1.7%	54 0.8%	65 2.7%	1082 5%
6M-4Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	4 0%
6M-4Y, MHCM floor - ceramic tiles	1 0%	0 0%	0 0%	0 0%	26 0.1%
6M-4Y, MHCM floor - cement	85 1.3%	49 0.8%	20 0.3%	25 1%	1406 6.5%
6M-4Y, MHCM floor - carpet	5 0.1%	1 0%	0 0%	1 0%	70 0.3%
5-19Y, MHCM walls - mud	90 1.4%	32 0.5%	4 0.1%	13 0.5%	432 2%
5-19Y, MHCM walls - brick	161 2.5%	42 0.7%	2 0%	12 0.5%	205 0.9%
5-19Y, MHCM walls - cement/plaster	38 0.6%	8 0.1%	1 0%	3 0.1%	136 0.6%
5-19Y, MHCM walls - cement/paint	41 0.6%	5 0.1%	2 0%	2 0.1%	214 1%
5-19Y, MHCM walls - other	11 0.2%	7 0.1%	4 0.1%	5 0.2%	142 0.7%
5-19Y, MHCM floor - natural floor	185 2.9%	67 1%	7 0.1%	24 1%	449 2.1%
5-19Y, MHCM floor - rudimentary floor	0 0%	1 0%	0 0%	0 0%	0 0%
5-19Y, MHCM floor - ceramic tiles	2 0%	0 0%	0 0%	0 0%	12 0.1%
5-19Y, MHCM floor - cement	149 2.3%	26 0.4%	6 0.1%	11 0.5%	636 2.9%
5-19Y, MHCM floor - carpet	5 0.1%	0 0%	0 0%	0 0%	32 0.1%
20+Y, MHCM walls - mud	46 0.7%	3 0%	4 0.1%	3 0.1%	520 2.4%
20+Y, MHCM walls - brick	90 1.4%	4 0.1%	0 0%	0 0%	298 1.4%
20+Y, MHCM walls - cement/plaster	10 0.2%	0 0%	1 0%	0 0%	188 0.9%
20+Y, MHCM walls - cement/paint	15 0.2%	1 0%	0 0%	0 0%	228 1.1%
20+Y, MHCM walls - other	10 0.2%	5 0.1%	0 0%	1 0%	168 0.8%
20+Y, MHCM floor - natural floor	124 1.9%	9 0.1%	4 0.1%	3 0.1%	651 3%
20+Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	2 0%
20+Y, MHCM floor - ceramic tiles	0 0%	1 0%	0 0%	0 0%	12 0.1%
20+Y, MHCM floor - cement	46 0.7%	3 0%	1 0%	1 0%	699 3.2%
20+Y, MHCM floor - carpet	1 0%	0 0%	0 0%	0 0%	38 0.2%

39. Secondary Outcome

Title	Number of Subjects by House Construction Material Regarding Walls and Floor at Survey 4
Description	The malaria prevention and risk factors characteristics were the following: Main house construction material (MHCM) walls and MHCM floor. MHCM walls data were assessed for the following sub-categories: mud, brick, cement/plaster, cement/paint, other. MHCM floor data were assessed for the following sub-categories: natural floor, rudimentary floor, vinyl or asphalt strips, ceramic tiles, cement, carpet. Note: Natural floor = earth, sand, dung; Rudimentary floor = wood planks, palm, bamboo. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, MHCM walls - mud	33 0.5%	14 0.2%	2 0%	14 0.6%	127 0.6%
6M-4Y, MHCM walls - brick	92 1.4%	76 1.2%	17 0.3%	33 1.4%	231 1.1%
6M-4Y, MHCM walls - cement/plaster	23 0.4%	8 0.1%	1 0%	2 0.1%	120 0.6%
6M-4Y, MHCM walls - cement/paint	6 0.1%	2 0%	0 0%	1 0%	81 0.4%
6M-4Y, MHCM walls - other	14 0.2%	3 0%	0 0%	4 0.2%	289 1.3%
6M-4Y, MHCM floor - natural floor	97 1.5%	76 1.2%	15 0.2%	37 1.5%	267 1.2%
6M-4Y, MHCM floor - rudimentary floor	0 0%	1 0%	0 0%	0 0%	0 0%
6M-4Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	0 0%	2 0%
6M-4Y, MHCM floor - ceramic tiles	0 0%	1 0%	0 0%	0 0%	16 0.1%
6M-4Y, MHCM floor - cement	70 1.1%	23 0.4%	5 0.1%	16 0.7%	541 2.5%
6M-4Y, MHCM floor - carpet	1 0%	2 0%	0 0%	1 0%	22 0.1%
5-19Y, MHCM walls - mud	40 0.6%	4 0.1%	0 0%	2 0.1%	36 0.2%
5-19Y, MHCM walls - brick	114 1.8%	27 0.4%	9 0.1%	5 0.2%	78 0.4%
5-19Y, MHCM walls - cement/plaster	24 0.4%	11 0.2%	4 0.1%	1 0%	52 0.2%
5-19Y, MHCM walls - cement/paint	13 0.2%	4 0.1%	1 0%	0 0%	30 0.1%
5-19Y, MHCM walls - other	7 0.1%	5 0.1%	2 0%	5 0.2%	132 0.6%
5-19Y, MHCM floor - natural floor	105 1.6%	27 0.4%	9 0.1%	6 0.3%	96 0.4%
5-19Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM floor - ceramic tiles	0 0%	0 0%	0 0%	0 0%	9 0%
5-19Y, MHCM floor - cement	89 1.4%	24 0.4%	7 0.1%	7 0.3%	214 1%
5-19Y, MHCM floor - carpet	4 0.1%	0 0%	0 0%	0 0%	8 0%
20+Y, MHCM walls - mud	18 0.3%	0 0%	1 0%	76 3.2%
20+Y, MHCM walls - brick	52 0.8%	1 0%	0 0%	171 7.1%
20+Y, MHCM walls - cement/plaster	13 0.2%	2 0%	0 0%	70 2.9%
20+Y, MHCM walls - cement/paint	1 0%	0 0%	0 0%	38 1.6%
20+Y, MHCM walls - other	3 0%	1 0%	0 0%	153 6.4%
20+Y, MHCM floor - natural floor	50 0.8%	1 0%	0 0%	201 8.4%
20+Y, MHCM floor - rudimentary floor	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM floor - vinyl/asphalt strips	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM floor - ceramic tiles	0 0%	0 0%	0 0%	8 0.3%
20+Y, MHCM floor - cement	37 0.6%	3 0%	1 0%	287 12%
20+Y, MHCM floor - carpet	0 0%	0 0%	0 0%	10 0.4%

40. Secondary Outcome

Title	Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 1
Description	The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other, missing. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open, missing. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows, missing. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, MHCM roof - grass/palm	112 1.7%	53 0.8%	22 0.3%	44 1.8%	453 2.1%
6M-4Y, MHCM roof - iron sheet	231 3.6%	109 1.7%	35 0.5%	74 3.1%	1980 9.2%
6M-4Y, MHCM roof - tiles	0 0%	0 0%	0 0%	0 0%	7 0%
6M-4Y, MHCM roof - other	30 0.5%	8 0.1%	1 0%	1 0%	40 0.2%
6M-4Y, MHCM windows/eaves - closed	193 3%	93 1.4%	31 0.5%	77 3.2%	1467 6.8%
6M-4Y, MHCM windows/eaves - open	76 1.2%	33 0.5%	17 0.3%	20 0.8%	486 2.2%
6M-4Y, MHCM windows/eaves - partially open	104 1.6%	44 0.7%	10 0.2%	22 0.9%	527 2.4%
6M-4Y, MHCM windows/eaves - missing	0 0%	0 0%	0 0%	0 0%	0 0%
6M-4Y, MHCM, nets - not present	322 5%	157 2.4%	54 0.8%	91 3.8%	1795 8.3%
6M-4Y, MHCM, nets - present on all windows	26 0.4%	6 0.1%	1 0%	21 0.9%	450 2.1%
6M-4Y, MHCM, nets - present on some windows	25 0.4%	7 0.1%	3 0%	7 0.3%	235 1.1%
5-19Y, MHCM roof - grass/palm	88 1.4%	19 0.3%	7 0.1%	28 1.2%	212 1%
5-19Y, MHCM roof - iron sheet	193 3%	48 0.7%	16 0.3%	30 1.3%	944 4.4%
5-19Y, MHCM roof - tiles	0 0%	0 0%	0 0%	0 0%	2 0%
5-19Y, MHCM roof - other	13 0.2%	4 0.1%	0 0%	0 0%	8 0%
5-19Y, MHCM roof - missing	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM windows/eaves - closed	154 2.4%	44 0.7%	14 0.2%	38 1.6%	669 3.1%
5-19Y, MHCM windows/eaves - open	71 1.1%	16 0.2%	5 0.1%	9 0.4%	233 1.1%
5-19Y, MHCM windows/eaves - partially open	69 1.1%	11 0.2%	4 0.1%	11 0.5%	264 1.2%
5-19Y, MHCM windows/eaves - missing	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM, nets - not present	256 4%	63 1%	21 0.3%	42 1.8%	853 3.9%
5-19Y, MHCM, nets - present on all windows	22 0.3%	6 0.1%	1 0%	11 0.5%	197 0.9%
5-19Y, MHCM, nets - present on some windows	16 0.2%	2 0%	1 0%	5 0.2%	116 0.5%
5-19Y, MHCM, nets - missing	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM roof - grass/palm	31 0.5%	5 0.1%	3 0%	280 11.7%
20+Y, MHCM roof - iron sheet	84 1.3%	12 0.2%	8 0.1%	1117 46.5%
20+Y, MHCM roof - tiles	0 0%	0 0%	0 0%	6 0.3%
20+Y, MHCM roof - other	4 0.1%	0 0%	0 0%	37 1.5%
20+Y, MHCM roof - missing	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM windows/eaves - closed	65 1%	8 0.1%	5 0.1%	798 33.3%
20+Y, MHCM windows/eaves - open	25 0.4%	5 0.1%	2 0%	291 12.1%
20+Y, MHCM windows/eaves - partially open	29 0.5%	4 0.1%	4 0.1%	351 14.6%
20+Y, MHCM windows/eaves - missing	0 0%	0 0%	0 0%	1 0%
20+Y, MHCM, nets - not present	107 1.7%	12 0.2%	7 0.1%	1081 45%
20+Y, MHCM, nets - present on all windows	8 0.1%	3 0%	2 0%	223 9.3%
20+Y, MHCM, nets - present on some windows	4 0.1%	2 0%	2 0%	136 5.7%
20+Y, MHCM, nets - missing	0 0%	0 0%	0 0%	1 0%

41. Secondary Outcome

Title	Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 2
Description	The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, MHCM roof - grass/palm	52 0.8%	32 0.5%	16 0.3%	23 1%	509 2.4%
6M-4Y, MHCM roof - iron sheet	201 3.1%	102 1.6%	46 0.7%	50 2.1%	2092 9.7%
6M-4Y, MHCM roof - tiles	0 0%	0 0%	0 0%	0 0%	1 0%
6M-4Y, MHCM roof - other	30 0.5%	14 0.2%	5 0.1%	3 0.1%	21 0.1%
6M-4Y, MHCM windows/eaves - closed	97 1.5%	54 0.8%	30 0.5%	39 1.6%	1411 6.5%
6M-4Y, MHCM windows/eaves - open	88 1.4%	45 0.7%	20 0.3%	19 0.8%	669 3.1%
6M-4Y, MHCM windows/eaves - partially open	98 1.5%	49 0.8%	17 0.3%	18 0.8%	543 2.5%
6M-4Y, MHCM, nets - not present	242 3.8%	136 2.1%	62 1%	66 2.8%	1843 8.5%
6M-4Y, MHCM, nets - present on all windows	26 0.4%	6 0.1%	4 0.1%	8 0.3%	626 2.9%
6M-4Y, MHCM, nets - present on some windows	15 0.2%	6 0.1%	1 0%	2 0.1%	154 0.7%
5-19Y, MHCM roof - grass/palm	76 1.2%	15 0.2%	3 0%	13 0.5%	207 1%
5-19Y, MHCM roof - iron sheet	241 3.8%	54 0.8%	26 0.4%	23 1%	940 4.3%
5-19Y, MHCM roof - tiles	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, MHCM roof - other	16 0.2%	2 0%	0 0%	0 0%	11 0.1%
5-19Y, MHCM windows/eaves - closed	159 2.5%	36 0.6%	16 0.3%	14 0.6%	610 2.8%
5-19Y, MHCM windows/eaves - open	85 1.3%	24 0.4%	6 0.1%	17 0.7%	294 1.4%
5-19Y, MHCM windows/eaves - partially open	89 1.4%	11 0.2%	7 0.1%	5 0.2%	254 1.2%
5-19Y, MHCM, nets - not present	290 4.5%	65 1%	23 0.4%	28 1.2%	793 3.7%
5-19Y, MHCM, nets - present on all windows	36 0.6%	5 0.1%	3 0%	6 0.3%	296 1.4%
5-19Y, MHCM, nets - present on some windows	7 0.1%	1 0%	3 0%	2 0.1%	69 0.3%
20+Y, MHCM roof - grass/palm	30 0.5%	3 0%	1 0%	2 0.1%	276 1.3%
20+Y, MHCM roof - iron sheet	80 1.2%	7 0.1%	4 0.1%	5 0.2%	1144 5.3%
20+Y, MHCM roof - tiles	1 0%	0 0%	0 0%	0 0%	2 0%
20+Y, MHCM roof - other	13 0.2%	0 0%	0 0%	0 0%	19 0.1%
20+Y, MHCM windows/eaves - closed	49 0.8%	6 0.1%	3 0%	4 0.2%	732 3.4%
20+Y, MHCM windows/eaves - open	42 0.7%	3 0%	2 0%	2 0.1%	372 1.7%
20+Y, MHCM windows/eaves - partially open	33 0.5%	1 0%	0 0%	1 0%	337 1.6%
20+Y, MHCM, nets - not present	115 1.8%	9 0.1%	3 0%	4 0.2%	1033 4.8%
20+Y, MHCM, nets - present on all windows	5 0.1%	0 0%	2 0%	3 0.1%	320 1.5%
20+Y, MHCM, nets - present on some windows	4 0.1%	1 0%	0 0%	0 0%	88 0.4%

42. Secondary Outcome

Title	Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 3
Description	The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, tiles, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, MHCM roof - grass/palm	55 0.9%	35 0.5%	12 0.2%	26 1.1%	464 2.1%
6M-4Y, MHCM roof - iron sheet	214 3.3%	125 1.9%	60 0.9%	63 2.6%	2111 9.8%
6M-4Y, MHCM roof - tiles	0 0%	0 0%	0 0%	1 0%	9 0%
6M-4Y, MHCM roof - other	10 0.2%	1 0%	2 0%	1 0%	4 0%
6M-4Y, MHCM windows/eaves - closed	164 2.6%	82 1.3%	38 0.6%	57 2.4%	1352 6.3%
6M-4Y, MHCM windows/eaves - open	86 1.3%	67 1%	28 0.4%	30 1.3%	845 3.9%
6M-4Y, MHCM windows/eaves - partially open	29 0.5%	12 0.2%	8 0.1%	4 0.2%	391 1.8%
6M-4Y, MHCM, nets - not present	244 3.8%	149 2.3%	63 1%	84 3.5%	1918 8.9%
6M-4Y, MHCM, nets - present on all windows	21 0.3%	10 0.2%	6 0.1%	4 0.2%	532 2.5%
6M-4Y, MHCM, nets - present on some windows	14 0.2%	2 0%	5 0.1%	3 0.1%	138 0.6%
5-19Y, MHCM roof - grass/palm	76 1.2%	16 0.2%	1 0%	5 0.2%	186 0.9%
5-19Y, MHCM roof - iron sheet	264 4.1%	77 1.2%	12 0.2%	30 1.3%	940 4.3%
5-19Y, MHCM roof - tiles	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, MHCM roof - other	1 0%	1 0%	0 0%	0 0%	2 0%
5-19Y, MHCM windows/eaves - closed	165 2.6%	58 0.9%	9 0.1%	18 0.8%	593 2.7%
5-19Y, MHCM windows/eaves - open	143 2.2%	26 0.4%	2 0%	16 0.7%	357 1.7%
5-19Y, MHCM windows/eaves - partially open	33 0.5%	10 0.2%	2 0%	1 0%	179 0.8%
5-19Y, MHCM, nets - not present	290 4.5%	83 1.3%	13 0.2%	28 1.2%	818 3.8%
5-19Y, MHCM, nets - present on all windows	31 0.5%	9 0.1%	0 0%	4 0.2%	261 1.2%
5-19Y, MHCM, nets - present on some windows	20 0.3%	2 0%	0 0%	3 0.1%	50 0.2%
20+Y, MHCM roof - grass/palm	45 0.7%	1 0%	2 0%	2 0.1%	259 1.2%
20+Y, MHCM roof - iron sheet	123 1.9%	12 0.2%	3 0%	2 0.1%	1123 5.2%
20+Y, MHCM roof - tiles	0 0%	0 0%	0 0%	0 0%	9 0%
20+Y, MHCM roof - other	3 0%	0 0%	0 0%	0 0%	11 0.1%
20+Y, MHCM windows/eaves - closed	112 1.7%	9 0.1%	4 0.1%	1 0%	715 3.3%
20+Y, MHCM windows/eaves - open	49 0.8%	2 0%	1 0%	3 0.1%	483 2.2%
20+Y, MHCM windows/eaves - partially open	10 0.2%	2 0%	0 0%	0 0%	204 0.9%
20+Y, MHCM, nets - not present	153 2.4%	12 0.2%	4 0.1%	4 0.2%	1052 4.9%
20+Y, MHCM, nets - present on all windows	11 0.2%	0 0%	0 0%	0 0%	262 1.2%
20+Y, MHCM, nets - present on some windows	7 0.1%	1 0%	1 0%	0 0%	88 0.4%

43. Secondary Outcome

Title	Number of Subjects Classified by House Construction Material Regarding Roof, Window/Eaves and Nets at Survey 4
Description	The malaria prevention and risk factors characteristics were the following: main house construction material (MHCM) roof, windows/eaves, nets. MHCM roof data were assessed for the following sub-categories: grass/palm, iron sheet, other. MHCM windows/eaves data were assessed for the following sub-categories: closed, open, partially open. MHCM nets data were assessed for the following sub-categories: nets not present, nets present on all windows, nets present on some windows. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, MHCM roof - grass/palm	51 0.8%	29 0.5%	6 0.1%	17 0.7%	161 0.7%
6M-4Y, MHCM roof - iron sheet	111 1.7%	67 1%	14 0.2%	28 1.2%	673 3.1%
6M-4Y, MHCM roof - other	6 0.1%	7 0.1%	0 0%	9 0.4%	14 0.1%
6M-4Y, MHCM windows/eaves - closed	124 1.9%	58 0.9%	13 0.2%	34 1.4%	725 3.4%
6M-4Y, MHCM windows/eaves - open	15 0.2%	13 0.2%	1 0%	5 0.2%	66 0.3%
6M-4Y, MHCM windows/eaves - partially open	29 0.5%	32 0.5%	6 0.1%	15 0.6%	57 0.3%
6M-4Y, MHCM, nets - not present	156 2.4%	95 1.5%	16 0.3%	51 2.1%	712 3.3%
6M-4Y, MHCM, nets - present on all windows	8 0.1%	1 0%	2 0%	2 0.1%	79 0.4%
6M-4Y, MHCM, nets - present on some windows	4 0.1%	7 0.1%	2 0%	1 0%	57 0.3%
5-19Y, MHCM roof - grass/palm	55 0.9%	10 0.2%	1 0%	2 0.1%	51 0.2%
5-19Y, MHCM roof - iron sheet	134 2.1%	37 0.6%	13 0.2%	9 0.4%	276 1.3%
5-19Y, MHCM roof - other	9 0.1%	4 0.1%	2 0%	2 0.1%	1 0%
5-19Y, MHCM windows/eaves - closed	139 2.2%	32 0.5%	11 0.2%	9 0.4%	292 1.4%
5-19Y, MHCM windows/eaves - open	24 0.4%	8 0.1%	4 0.1%	1 0%	17 0.1%
5-19Y, MHCM windows/eaves - partially open	35 0.5%	11 0.2%	1 0%	3 0.1%	19 0.1%
5-19Y, MHCM, nets - not present	162 2.5%	41 0.6%	14 0.2%	13 0.5%	276 1.3%
5-19Y, MHCM, nets - present on all windows	17 0.3%	5 0.1%	2 0%	0 0%	25 0.1%
5-19Y, MHCM, nets - present on some windows	19 0.3%	5 0.1%	0 0%	0 0%	27 0.1%
20+Y, MHCM roof - grass/palm	27 0.4%	0 0%	1 0%	98 4.1%
20+Y, MHCM roof - iron sheet	56 0.9%	4 0.1%	0 0%	394 16.4%
20+Y, MHCM roof - other	4 0.1%	0 0%	1 0%	16 0.7%
20+Y, MHCM windows/eaves - closed	64 1%	4 0.1%	1 0%	421 17.5%
20+Y, MHCM windows/eaves - open	9 0.1%	0 0%	0 0%	33 1.4%
20+Y, MHCM windows/eaves - partially open	14 0.2%	0 0%	0 0%	54 2.3%
20+Y, MHCM, nets - not present	74 1.2%	4 0.1%	1 0%	438 18.3%
20+Y, MHCM, nets - present on all windows	7 0.1%	0 0%	0 0%	32 1.3%
20+Y, MHCM, nets - present on some windows	6 0.1%	0 0%	0 0%	38 1.6%

44. Secondary Outcome

Title	Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 1
Description	The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water), missing; and Presence of electricity (PE): Yes, No, missing. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 1)	Medium PD Group (Survey 1)	High PD Group (Survey 1)	Very High PD Group (Survey 1)	Neg PD Group (Survey 1)
Arm/Group Description	Subjects from Survey 1 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1 not infected with P.falciparum.
Measure Participants	786	258	81	188	5088
6M-4Y, MSDW - bottled water	1 0%	0 0%	0 0%	0 0%	22 0.1%
6M-4Y, MSDW - closed water source	246 3.8%	111 1.7%	28 0.4%	49 2%	1637 7.6%
6M-4Y, MSDW - open water source	126 2%	59 0.9%	30 0.5%	70 2.9%	821 3.8%
6M-4Y, PE - Yes	66 1%	24 0.4%	7 0.1%	13 0.5%	780 3.6%
6M-4Y, PE - No	307 4.8%	146 2.3%	51 0.8%	106 4.4%	1700 7.9%
5-19Y, MSDW - bottled water	1 0%	0 0%	0 0%	0 0%	9 0%
5-19Y, MSDW - closed water source	182 2.8%	41 0.6%	13 0.2%	19 0.8%	767 3.5%
5-19Y, MSDW - open water source	111 1.7%	30 0.5%	10 0.2%	39 1.6%	390 1.8%
5-19Y, MSDW - missing	0 0%	0 0%	0 0%	0 0%	1 0%
5-19Y, PE - Yes	48 0.7%	13 0.2%	4 0.1%	4 0.2%	384 1.8%
5-19Y, PE - No	246 3.8%	58 0.9%	19 0.3%	54 2.3%	782 3.6%
5-19Y, PE - missing	0 0%	0 0%	0 0%	0 0%	1 0%
20+Y, MSDW - bottled water	1 0%	0 0%	0 0%	12 0.5%
20+Y, MSDW - closed water source	82 1.3%	10 0.2%	4 0.1%	943 39.3%
20+Y, MSDW - open water source	36 0.6%	7 0.1%	7 0.1%	485 20.2%
20+Y, MSDW - missing	0 0%	0 0%	0 0%	1 0%
20+Y, PE - Yes	18 0.3%	5 0.1%	1 0%	397 16.5%
20+Y, PE - No	101 1.6%	12 0.2%	10 0.2%	1043 43.5%
20+Y, PE - missing	0 0%	0 0%	0 0%	1 0%

45. Secondary Outcome

Title	Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 2
Description	The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 2)	Medium PD Group (Survey 2)	High PD Group (Survey 2)	Very High PD Group (Survey 2)	Neg PD Group (Survey 2)
Arm/Group Description	Subjects from Survey 2 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2 not infected with P.falciparum.
Measure Participants	740	229	101	119	5222
6M-4Y, MSDW - bottled water	1 0%	0 0%	0 0%	0 0%	4 0%
6M-4Y, MSDW - closed water source	207 3.2%	93 1.4%	44 0.7%	42 1.8%	1784 8.3%
6M-4Y, MSDW - open water source	75 1.2%	55 0.9%	23 0.4%	34 1.4%	835 3.9%
6M-4Y, PE - Yes	49 0.8%	18 0.3%	9 0.1%	9 0.4%	824 3.8%
6M-4Y, PE - No	234 3.7%	130 2%	58 0.9%	67 2.8%	1799 8.3%
5-19Y, MSDW - bottled water	1 0%	0 0%	0 0%	0 0%	3 0%
5-19Y, MSDW - closed water source	229 3.6%	45 0.7%	22 0.3%	21 0.9%	760 3.5%
5-19Y, MSDW - open water source	103 1.6%	26 0.4%	7 0.1%	15 0.6%	395 1.8%
5-19Y, PE - Yes	60 0.9%	12 0.2%	11 0.2%	4 0.2%	366 1.7%
5-19Y, PE - No	273 4.3%	59 0.9%	18 0.3%	32 1.3%	792 3.7%
20+Y, MSDW - bottled water	0 0%	0 0%	0 0%	0 0%	4 0%
20+Y, MSDW - closed water source	87 1.4%	7 0.1%	4 0.1%	1 0%	987 4.6%
20+Y, MSDW - open water source	37 0.6%	3 0%	1 0%	6 0.3%	450 2.1%
20+Y, PE - Yes	23 0.4%	4 0.1%	2 0%	1 0%	436 2%
20+Y, PE - No	101 1.6%	6 0.1%	3 0%	6 0.3%	1005 4.6%

46. Secondary Outcome

Title	Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 3
Description	The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 3)	Medium PD Group (Survey 3)	High PD Group (Survey 3)	Very High PD Group (Survey 3)	Neg PD Group (Survey 3)
Arm/Group Description	Subjects from Survey 3 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3 not infected with P.falciparum.
Measure Participants	791	268	92	130	5119
6M-4Y, MSDW - bottled water	0 0%	0 0%	0 0%	1 0%	26 0.1%
6M-4Y, MSDW - closed water source	185 2.9%	97 1.5%	37 0.6%	53 2.2%	1613 7.5%
6M-4Y, MSDW - open water source	94 1.5%	64 1%	37 0.6%	37 1.5%	949 4.4%
6M-4Y, PE - Yes	36 0.6%	25 0.4%	8 0.1%	11 0.5%	775 3.6%
6M-4Y, PE - No	243 3.8%	136 2.1%	66 1%	80 3.3%	1813 8.4%
5-19Y, MSDW - bottled water	0 0%	1 0%	0 0%	0 0%	13 0.1%
5-19Y, MSDW - closed water source	214 3.3%	51 0.8%	6 0.1%	23 1%	715 3.3%
5-19Y, MSDW - open water source	127 2%	42 0.7%	7 0.1%	12 0.5%	401 1.9%
5-19Y, PE - Yes	56 0.9%	19 0.3%	5 0.1%	7 0.3%	348 1.6%
5-19Y, PE - No	285 4.5%	75 1.2%	8 0.1%	28 1.2%	781 3.6%
20+Y, MSDW - bottled water	0 0%	0 0%	0 0%	0 0%	15 0.1%
20+Y, MSDW - closed water source	101 1.6%	8 0.1%	2 0%	1 0%	884 4.1%
20+Y, MSDW - open water source	70 1.1%	5 0.1%	3 0%	3 0.1%	503 2.3%
20+Y, PE - Yes	19 0.3%	3 0%	0 0%	1 0%	386 1.8%
20+Y, PE - No	152 2.4%	10 0.2%	5 0.1%	3 0.1%	1016 4.7%

47. Secondary Outcome

Title	Number of Subjects Classified by House Information Regarding Main Source of the Drinking Water and Presence of Electricity at Survey 4
Description	The malaria prevention and risk factors characteristics were the following: Main source of drinking water (MSDW): bottled water, closed water source (piped water, tube well, dug well, protected well), open water source (unprotected well, spring water, rainwater, tanker truck, surface water); and Presence of electricity (PE): Yes, No. Data were collected across centers from subjects between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. Results were presented per the following P. falciparum parasite density status subgroups: Low, Medium, High, Very high, and Negative (Neg).
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Low PD Group (Survey 4)	Medium PD Group (Survey 4)	High PD Group (Survey 4)	Very High PD Group (Survey 4)	Neg PD Group (Survey 4)
Arm/Group Description	Subjects from Survey 4 with low P. falciparum parasite density (PD), (less than [<] 2500 parasites per microliter [parasites/μL]. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with medium P. falciparum parasite density (PD), (2500 - 9999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with high P. falciparum parasite density (PD), (10000 - 19999 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 with very high P. falciparum parasite density (PD), (greater than or equal to [≥] 20000 parasites/μL). Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4 not infected with P.falciparum.
Measure Participants	453	158	36	68	1684
6M-4Y, MSDW - bottled water	0 0%	0 0%	0 0%	0 0%	1 0%
6M-4Y, MSDW - closed water source	139 2.2%	79 1.2%	15 0.2%	38 1.6%	656 3%
6M-4Y, MSDW - open water source	29 0.5%	24 0.4%	5 0.1%	16 0.7%	191 0.9%
6M-4Y, PE - Yes	20 0.3%	5 0.1%	0 0%	3 0.1%	384 1.8%
6M-4Y, PE - No	148 2.3%	98 1.5%	20 0.3%	51 2.1%	464 2.1%
5-19Y, MSDW - bottled water	0 0%	0 0%	0 0%	0 0%	0 0%
5-19Y, MSDW - closed water source	155 2.4%	38 0.6%	12 0.2%	9 0.4%	247 1.1%
5-19Y, MSDW - open water source	43 0.7%	13 0.2%	4 0.1%	4 0.2%	81 0.4%
5-19Y, PE - Yes	23 0.4%	8 0.1%	3 0%	4 0.2%	161 0.7%
5-19Y, PE - No	175 2.7%	43 0.7%	13 0.2%	9 0.4%	167 0.8%
20+Y, MSDW - bottled water	0 0%	0 0%	0 0%	1 0%
20+Y, MSDW - closed water source	69 1.1%	2 0%	1 0%	391 16.3%
20+Y, MSDW - open water source	18 0.3%	2 0%	0 0%	116 4.8%
20+Y, PE - Yes	9 0.1%	2 0%	0 0%	206 8.6%
20+Y, PE - No	78 1.2%	2 0%	1 0%	302 12.6%

48. Secondary Outcome

Title	Number of Subjects With Malaria Prevention Measures (MPM) at Each Survey
Description	The malaria prevention measures (MPM) data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for each Survey. The MPM results include the following categories: Use of Mosquito coils over 7 days (UMc > 7D), Use of Insecticide spray over 7 days (UIs > 7D), Use of Commercial Repellents over 7 days (UCR > 7D), Use of Traditional Repellents over 7 days (UTR > 7D), Use of none of above over 7 days (Una >7D), Use of indoor residual spray in past 12 months to spray interior walls (Uirs past 12M), Use of indoor residual spray - number of months ago (Uirs-nM) or Use of indoor residual spray- no spray (Uirs-no spray): the number of months ago for each Uirs-nM sub-categories is defined using the following [x Months]. Not all Uirs-nM sub-categories were analyzed in each survey.
Time Frame	At each Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
Measure Participants	6401	6411	6400	2399
[6M-4Y], UMc > 7D, Yes	433 6.8%	398 6.2%	348 5.4%	239 10%
[6M-4Y], UMc > 7D, Missing/No	2767 43.2%	2799 43.6%	2845 44.5%	954 39.8%
[6M-4Y], UIs > 7D, Yes	101 1.6%	60 0.9%	48 0.8%	27 1.1%
[6M-4Y], UIs > 7D, Missing/No	3099 48.4%	3137 48.9%	3145 49.1%	1166 48.6%
[6M-4Y], UCR > 7D, Yes	4 0.1%	5 0.1%	24 0.4%	20 0.8%
[6M-4Y], UCR > 7D, Missing/No	3196 49.9%	3192 49.8%	3169 49.5%	1173 48.9%
[6M-4Y], UTR > 7D, Yes	7 0.1%	9 0.1%	0 0%	2 0.1%
[6M-4Y], UTR > 7D, Missing/No	3193 49.9%	3188 49.7%	3193 49.9%	1191 49.6%
[6M-4Y], Una >7D, Yes	2663 41.6%	2726 42.5%	2778 43.4%	905 37.7%
[6M-4Y], Una >7D, Missing/No	537 8.4%	471 7.3%	415 6.5%	288 12%
[6M-4Y], Uirs past 12M, Yes	59 0.9%	15 0.2%	7 0.1%	3 0.1%
[6M-4Y], Uirs past 12M, Missing/No	3141 49%	3182 49.6%	3186 49.8%	1190 49.6%
[6M-4Y], Uirs-nM [1 Month]	9 0.1%	1 0%	1 0%	0 0%
[6M-4Y], Uirs-nM [11 Months]	1 0%
[6M-4Y], Uirs-nM [12 Months]	5 0.1%	1 0%	2 0%
[6M-4Y], Uirs-nM [10 Months]	1 0%
[6M-4Y], Uirs-nM [2 Months]	6 0.1%	3 0%	1 0%
[6M-4Y], Uirs-nM [3 Months]	21 0.3%	5 0.1%	3 0%	1 0%
[6M-4Y], Uirs-nM [4 Months]	9 0.1%	2 0%	1 0%
[6M-4Y], Uirs-nM [5 Months]	1 0%	2 0%
[6M-4Y], Uirs-nM [6 Months]	6 0.1%
[6M-4Y], Uirs-nM [7 Months]	1 0%	1 0%
[6M-4Y], Uirs-nM [9 Months]	1 0%
[6M-4Y], Uirs-nM [no spray]	3141 49%	3182 49.6%	3186 49.8%	1190 49.6%
[5-19Y], UMc > 7D, Yes	227 3.5%	209 3.3%	180 2.8%	127 5.3%
[5-19Y], UMc > 7D, Missing/No	1386 21.6%	1418 22.1%	1432 22.4%	479 20%
[5-19Y], UIs > 7D, Yes	45 0.7%	32 0.5%	20 0.3%	10 0.4%
[5-19Y], UIs > 7D, Missing/No	1568 24.5%	1595 24.9%	1592 24.9%	596 24.8%
[5-19Y], UCR > 7D, Yes	4 0.1%	2 0%	12 0.2%	7 0.3%
[5-19Y], UCR > 7D, Missing/No	1609 25.1%	1625 25.3%	1600 25%	599 25%
[5-19Y], UTR > 7D, Yes	3 0%	3 0%	0 0%	2 0.1%
[5-19Y], UTR > 7D, Missing/No	1610 25.1%	1624 25.3%	1612 25.2%	604 25.2%
[5-19Y], Una >7D, Yes	1336 20.9%	1381 21.5%	1401 21.9%	460 19.2%
[5-19Y], Una >7D, Missing/No	277 4.3%	246 3.8%	211 3.3%	146 6.1%
[5-19Y], Uirs past 12M, Yes	24 0.4%	8 0.1%	3 0%	1 0%
[5-19Y], Uirs past 12M, Missing/No	1589 24.8%	1619 25.2%	1609 25.1%	605 25.2%
[5-19Y], Uirs-nM [1 Month]	2 0%	1 0%	1 0%
[5-19Y], Uirs-nM [11 Months]	1 0%
[5-19Y], Uirs-nM [12 Months]	2 0%	1 0%	1 0%
[5-19Y], Uirs-nM [2 Months]	1 0%	2 0%	0 0%
[5-19Y], Uirs-nM [3 Months]	13 0.2%	3 0%	0 0%	0 0%
[5-19Y], Uirs-nM [4 Months]	2 0%	0 0%	1 0%
[5-19Y], Uirs-nM [5 Months]	0 0%	1 0%
[5-19Y], Uirs-nM [6 Months]	4 0.1%
[5-19Y], Uirs-nM [7 Months]	0 0%	0 0%
[5-19Y], Uirs-nM [9 Months]	0 0%
[5-19Y], Uirs-nM [no spray]	1589 24.8%	1619 25.2%	1609 25.1%	605 25.2%
[Y20+], UMc > 7D, Yes	196 3.1%	199 3.1%	167 2.6%	117 4.9%
[Y20+], UMc > 7D, Missing/No	1392 21.7%	1388 21.6%	1428 22.3%	483 20.1%
[Y20+], UIs > 7D, Yes	46 0.7%	30 0.5%	28 0.4%	11 0.5%
[Y20+], UIs > 7D, Missing/No	1542 24.1%	1557 24.3%	1567 24.5%	589 24.5%
[Y20+], UCR > 7D, Yes	0 0%	4 0.1%	12 0.2%	12 0.5%
[Y20+], UCR > 7D, Missing/No	1588 24.8%	1583 24.7%	1583 24.7%	588 24.5%
[Y20+], UTR > 7D, Yes	4 0.1%	4 0.1%	0 0%	0 0%
[Y20+], UTR > 7D, Missing/No	1584 24.7%	1583 24.7%	1595 24.9%	600 25%
[Y20+], Una >7D, Yes	1346 21%	1350 21%	1392 21.8%	460 19.2%
[Y20+], Una >7D, Missing/No	242 3.8%	237 3.7%	203 3.2%	140 5.8%
[Y20+], Uirs past 12M, Yes	32 0.5%	7 0.1%	2 0%	2 0.1%
[Y20+], Uirs past 12M, Missing/No	1556 24.3%	1580 24.6%	1593 24.9%	598 24.9%
[Y20+], Uirs-nM [1 Month]	7 0.1%	0 0%	0 0%
[Y20+], Uirs-nM [11 Months]	0 0%
[Y20+], Uirs-nM [12 Months]	3 0%	0 0%	1 0%
[Y20+], Uirs-nM [10 Months]	1 0%
[Y20+], Uirs-nM [2 Months]	4 0.1%	1 0%	1 0%
[Y20+], Uirs-nM [3 Months]	8 0.1%	3 0%	1 0%	0 0%
[Y20+], Uirs-nM [4 Months]	6 0.1%	2 0%	0 0%
[Y20+], Uirs-nM [5 Months]	1 0%	1 0%
[Y20+], Uirs-nM [6 Months]	2 0%
[Y20+], Uirs-nM [7 Months]	1 0%	0 0%
[Y20+], Uirs-nM [9 Months]	0 0%
[Y20+], Uirs-nM [no spray]	1556 24.3%	1580 24.6%	1593 24.9%	598 24.9%

49. Secondary Outcome

Title	Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 1
Description	Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 1. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (6M-4Y) (Survey 1)	Overall Study Group (5-19Y) (Survey 1)	Overall Study Group (20Y+) (Survey 1)
Arm/Group Description	Subjects from Survey 1, aged between and including 6 months (6M) to 4 years (4Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1, aged 5 to 19 years (5-19Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 1, aged 20 years or older (20Y+), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.
Measure Participants	3200	1613	1588
P.Malariae, Pos	19 0.3%	21 0.3%	1 0%
P.Malariae, Neg	3181 49.7%	1592 24.8%	1587 24.8%
P.Vivax, Pos	0 0%	0 0%	0 0%
P.Vivax, Neg	3200 50%	1613 25.1%	1588 24.8%
P.Ovale, Pos	3 0%	1 0%	0 0%
P.Ovale, Neg	3197 49.9%	1612 25.1%	1588 24.8%

50. Secondary Outcome

Title	Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 2
Description	Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 2. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (6M-4Y) (Survey 2)	Overall Study Group (5-19Y) (Survey 2)	Overall Study Group (20Y+) (Survey 2)
Arm/Group Description	Subjects from Survey 2, aged between and including 6 months (6M) to 4 years (4Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2, aged 5 to 19 years (5-19Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 2, aged 20 years or older (20Y+), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.
Measure Participants	3197	1627	1587
P.Malariae, Pos	32 0.5%	27 0.4%	2 0%
P.Malariae, Neg	3165 49.4%	1600 24.9%	1585 24.8%
P.Vivax, Pos	0 0%	0 0%	0 0%
P.Vivax, Neg	3197 49.9%	1627 25.4%	1587 24.8%
P.Ovale, Pos	6 0.1%	3 0%	2 0%
P.Ovale, Neg	3191 49.8%	1624 25.3%	1585 24.8%

51. Secondary Outcome

Title	Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 3
Description	Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 3. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (6M-4Y) (Survey 3)	Overall Study Group (5-19Y) (Survey 3)	Overall Study Group (20Y+) (Survey 3)
Arm/Group Description	Subjects from Survey 3, aged between and including 6 months (6M) to 4 years (4Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3, aged 5 to 19 years (5-19Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 3, aged 20 years or older (20Y+), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.
Measure Participants	3193	1612	1595
P.Malariae, Pos	48 0.7%	27 0.4%	0 0%
P.Malariae, Neg	3145 49.1%	1585 24.7%	1595 24.9%
P.Vivax, Pos	0 0%	0 0%	0 0%
P.Vivax, Neg	3193 49.9%	1612 25.1%	1595 24.9%
P.Ovale, Pos	6 0.1%	4 0.1%	1 0%
P.Ovale, Neg	3187 49.8%	1608 25.1%	1594 24.9%

52. Secondary Outcome

Title	Number of Subjects With Plasmodium Species Other Than P. Falciparum at Survey 4
Description	Data were collected across centers from subjects with age between and including: 6M-4Y, 5-19 Y and 20Y+, for Survey 4. The other Plasmodium species assessed were: P. Malaria, P. Vivax, P. Ovale. Infection were determined using a blood smear slide, and categorized according positive (Pos) and negative (Neg) results.
Time Frame	At Survey visit

Outcome Measure Data

Analysis Population Description

Analysis was performed on the According-to-Protocol (ATP) Cohort, which included all evaluable subjects for whom at least one laboratory result of blood sample was available at the survey visit.

Arm/Group Title	Overall Study Group (6M-4Y) (Survey 4)	Overall Study Group (5-19Y) (Survey 4)	Overall Study Group (20Y+) (Survey 4)
Arm/Group Description	Subjects from Survey 4, aged between and including 6 months (6M) to 4 years (4Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4, aged 5 to 19 years (5-19Y), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.	Subjects from Survey 4, aged 20 years or older (20Y+), enrolled in catchment areas of study 110021 (NCT00866619), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy.
Measure Participants	1193	606	600
P.Malariae, Pos	32 0.5%	28 0.4%	0 0%
P.Malariae, Neg	1161 18.1%	578 9%	600 9.4%
P.Vivax, Pos	0 0%	0 0%	0 0%
P.Vivax, Neg	1193 18.6%	606 9.4%	600 9.4%
P.Ovale, Pos	3 0%	3 0%	1 0%
P.Ovale, Neg	1190 18.6%	603 9.4%	599 9.4%

53. Secondary Outcome

Title	Number of Subjects With Serious Adverse Events (SAEs) Related to Study Procedure for Each Survey
Description	Serious adverse events (SAEs) assessed include medical occurrences that result in death, are life threatening, require hospitalization or prolongation of hospitalization or result in disability/incapacity. Capillary blood sampling was the only invasive procedure involved in this study. SAEs related to this procedure were recorded at the Survey visit.
Time Frame	At each Survey visit

Outcome Measure Data

Analysis Population Description

The analysis was performed on the Total cohort, which included all subjects enrolled in the study.

Arm/Group Title	Overall Study Group (Survey 1)	Overall Study Group (Survey 2)	Overall Study Group (Survey 3)	Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.	Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
Measure Participants	6404	6414	6400	2400
Count of Participants [Participants]	0 0%	0 0%	0 0%	0 0%

Adverse Events

Time Frame	Capillary blood sampling was the only invasive procedure involved in this study. Serious adverse events (SAEs) related to this procedure were recorded at each survey visit.
Adverse Event Reporting Description	Anticipated and unanticipated adverse events symptoms were not collected in the study.
Arm/Group Title	Overall Study Group (Survey 1)		Overall Study Group (Survey 2)		Overall Study Group (Survey 3)		Overall Study Group (Survey 4)
Arm/Group Description	Subjects at least 6 months of age at the time of Survey 1, conducted at Year 1 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.		Subjects at least 6 months of age at the time of Survey 2, conducted at Year 2 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.		Subjects at least 6 months of age at the time of Survey 3, conducted at Year 3 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.		Subjects at least 6 months of age at the time of Survey 4, conducted at Year 4 of the 4 annual cross sectional surveys performed preferably at peak transmission (end of rainy season), infected with P. falciparum parasite. Infection determined using a blood smear slide and determined using microscopy. Subjects were enrolled from the catchment areas of study 110021 (NCT00866619) but those who previously participated in study 110021 were excluded from this epidemiological study.
All Cause Mortality
	Overall Study Group (Survey 1)		Overall Study Group (Survey 2)		Overall Study Group (Survey 3)		Overall Study Group (Survey 4)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	0/6404 (0%)		0/6414 (0%)		0/6400 (0%)		0/2400 (0%)
Serious Adverse Events
	Overall Study Group (Survey 1)		Overall Study Group (Survey 2)		Overall Study Group (Survey 3)		Overall Study Group (Survey 4)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	0/6404 (0%)		0/6414 (0%)		0/6400 (0%)		0/2400 (0%)
Other (Not Including Serious) Adverse Events
	Overall Study Group (Survey 1)		Overall Study Group (Survey 2)		Overall Study Group (Survey 3)		Overall Study Group (Survey 4)
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	0/0 (NaN)		0/0 (NaN)		0/0 (NaN)		0/0 (NaN)

Limitations/Caveats

[Not Specified]

More Information

Certain Agreements

Principal Investigators are NOT employed by the organization sponsoring the study.

GSK agreements may vary with individual investigators, but will not prohibit any investigator from publishing. GSK supports the publication of results from all centers of a multi-center trial but requests that reports based on single-site data not precede the primary publication of the entire clinical trial.