Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy
Sponsor
Alliance for Clinical Trials in Oncology (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT03578081
Collaborator
National Cancer Institute (NCI) (NIH)
690
566
2
57.5
1.2
0
Study Details
Study Description
Brief Summary
This randomized phase III trial studies how well olanzapine with or without fosaprepitant work in preventing chemotherapy induced nausea and vomiting in cancer patients receiving chemotherapy that causes vomiting. Olanzapine and fosaprepitant dimeglumine may help control nausea and vomiting in patients during chemotherapy. Olanzapine is usually given in combination with other drugs, including fosaprepitant dimeglumine. It is not yet known if olanzapine when given with other drugs, is still effective without using fosaprepitant dimeglumine for controlling nausea and vomiting.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
PRIMARY OBJECTIVES:
- To compare between the two study arms the proportion of patients with no nausea for the overall (0-120 hours post-chemotherapy), acute (0-24 hours post-chemotherapy), and delayed periods (24-120 hours post-chemotherapy) for patients receiving highly emetogenic chemotherapy (HEC).
SECONDARY OBJECTIVES:
-
To compare between the two study arms the complete response (CR) rates (no emetic episodes and no use of rescue medication) in the acute, delayed, and overall periods.
-
To compare between the two study arms, the incidences of potential toxicities that have been ascribed to olanzapine.
-
To perform an economic evaluation of olanzapine and fosaprepitant dimeglumine (fosaprepitant) versus (vs.) olanzapine in patients receiving HEC (noting that all patients will also receive dexamethasone and a 5HT3 receptor antagonist).
-
To explore the efficacy of olanzapine in chemotherapy cycles two to four, for patients who elect to continue on the same antiemetic regimen received in cycle one, in chemotherapy cycles two to four (continuation phase), by documenting nausea and complete response.
-
To explore the safety of olanzapine in chemotherapy cycles two to four, for patients who elect to continue on the same antiemetic regimen received in cycle one, in chemotherapy cycles two to four (continuation phase), by recording any adverse events or drug related toxicities.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive palonosetron hydrochloride intravenously (IV) over 30 seconds or ondansetron hydrochloride IV over 2-5 minutes or orally (PO) on day 1, dexamethasone PO on days 1-4, fosaprepitant dimeglumine IV over 20-30 minutes on day 1, and olanzapine PO on days 1-4. Treatment may repeat every 4 days for up to 3 courses in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive palonosetron hydrochloride IV over 30 seconds or ondansetron hydrochloride IV over 2-5 minutes or PO on day 1, dexamethasone PO on days 1-4, placebo IV over 20-30 minutes on day 1, and olanzapine PO on days 1-4. Treatment (with no placebo) may repeat every 4 days for up to 3 courses in the absence of disease progression or unacceptable toxicity.
After completion of study, patients are followed up periodically.
Study Design
Study Type:
Interventional
Actual Enrollment
:
690 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Supportive Care
Official Title:
Olanzapine With or Without Fosaprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)in Patients Receiving Highly Emetogenic Chemotherapy (HEC): A Phase III Randomized, Double Blind, Placebo-Controlled Trial
Actual Study Start Date
:
Oct 15, 2018
Actual Primary Completion Date
:
Nov 8, 2021
Anticipated Study Completion Date
:
Aug 1, 2023
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (fosaprepitant dimeglumine, olanzapine) Patients receive palonosetron hydrochloride IV over 30 seconds or ondansetron hydrochloride IV over 2-5 minutes or PO on day 1, dexamethasone PO on days 1-4, fosaprepitant dimeglumine IV over 20-30 minutes on day 1, and olanzapine PO on days 1-4. Treatment may repeat every 4 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. |
Drug: Palonosetron Hydrochloride
Given IV
Drug: Ondansetron Hydrochloride
Given IV or PO
Drug: Dexamethasone
Given PO
Drug: Fosaprepitant Dimeglumine
Given IV
Drug: Olanzapine
Given PO
|
| Active Comparator: Arm II (placebo, olanzapine) Patients receive palonosetron hydrochloride IV over 30 seconds or ondansetron hydrochloride IV over 2-5 minutes or PO on day 1, dexamethasone PO on days 1-4, placebo IV over 20-30 minutes on day 1, and olanzapine PO on days 1-4. Treatment (with no placebo) may repeat every 4 days for up to 3 courses in the absence of disease progression or unacceptable toxicity. |
Drug: Palonosetron Hydrochloride
Given IV
Drug: Ondansetron Hydrochloride
Given IV or PO
Drug: Dexamethasone
Given PO
Drug: Olanzapine
Given PO
Other: Placebo
Given IV
|
Outcome Measures
Primary Outcome Measures
- No nausea rate defined as a response of 0 in the nausea item of Nausea and Vomiting Daily Diary/Questionnaire in the overall (0-120 hours), acute (0-24 hours), and delayed (24-120 hours) periods [Up to 120 hours]
The specific measure will be based on the proportion of patients with a value of 0, as measured by the single nausea item (scale 0-10, 0 is no symptoms, 10 is worst symptoms) of the Questionnaire. A modified intent-to-treat principle will be applied for statistical analysis of efficacy in evaluable patients. The proportions of patients with no nausea during the overall, the acute, and the delayed period will be summarized by treatment arm. They will be tested in a sequential manner, using a Simes gatekeeping procedure to maintain the overall significance level at the specified by the Lan-DeMets family of alpha spending function. The difference in no nausea proportions between arms will be estimated along with a one-sided 95% confidence interval. The tests and the confidence intervals will be constructed using normal approximation of the binomial distribution adjusted for the non-inferiority margin.
Secondary Outcome Measures
- Complete response (CR) (no emetic episodes and no use of rescue medication) during the acute, delayed and the overall periods as measured by the Nausea and Vomiting Daily Diary/Questionnaire [Up to 120 hours]
The specific measure will be based on the proportion of patients who answered "None" to both questions concerning Vomiting episode(None, Once, Twice, More than twice) and number of extra nausea/vomiting pills taken (None, One, Two, More than two) in the Nausea and Vomiting Daily Diary/Questionnaire. The CR rate for the overall, the acute, and the delayed period will be summarized by treatment arm and will be compared using a Chi-squared test. The difference in CR rates between arms will be estimated along with a 95% confidence interval.
- Potential toxicities as ascribed to olanzapine as measured by the Nausea and Vomiting Daily Diary/Questionnaire [Up to 1 year]
Potential toxicities includes nausea, undesired sedation, and undesired appetite, measured by three individual items ( nausea, undesired sedation, undesired appetite) of the Nausea and Vomiting Daily Dairy/Questionnaire(scale 0-10, 0 is no symptoms, 10 is worst symptoms). Incidences of toxicities will be summarized by type and by treatment arm. Incidences of toxicities will be compared between arms using a Chi-squared test or the Fisher's exact test as appropriate. In addition, undesired sedation and appetite increase as collected in the Nausea and Vomiting Daily Diary/Questionnaire will be analyzed by repeated measures analyses including descriptive statistics, graphical approaches, and growth curve models to account for the factor of day and time trend.
- Nausea scores (0-10) repeatedly measured by the Nausea and Vomiting Daily Diary/Questionnaire [Up to 1 year]
The specific measure will be based on the by the single nausea item (scale 0-10, 0 is no symptoms, 10 is worst symptoms) of the Nausea and Vomiting Daily Diary/Questionnaire. Nausea scores (0-10) repeatedly measured by the Nausea and Vomiting Daily Diary/Questionnaire will be analyzed using the repeated measures analyses and growth curve models as described above for undesired sedation and increase in appetite.
- Frequency of rescue medication as measured by the Nausea and Vomiting Daily Diary/Questionnaire [Up to 1 year]
The specific measure will be based on the single item : number of extra nausea/vomiting pills taken (None, One , Twice, More than twice) of the Nausea and Vomiting Daily Diary/Questionnaire. The proportion of patients taking any rescue medication as reported in the Nausea and Vomiting Daily Diary/Questionnaire will be summarized by treatment arm and will be compared between arms using a Chi-squared test or the Fisher's exact test as appropriate. In addition, the number of pills taken will be analyzed using the repeated measures analyses and growth curve models.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Diagnosis of malignant disease of any stage; (stage I through stage IV)
-
No prior history of chemotherapy for any malignancy
-
Scheduled to receive intravenous HEC (highly emetogenic chemotherapy) (either cisplatin-containing regimen or doxorubicin and cyclophosphamide [AC]); cisplatin, given on a single day, at a dose of >= 70 mg/m2, with or without other chemotherapy agent(s) OR doxorubicin (60 mg/m2) plus cyclophosphamide (600 mg/m^2)
-
No nausea or vomiting =< 24 hours prior to registration
-
Negative pregnancy test (serum or urine) done =< 7 days prior to registration, for women of childbearing potential only
- A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
-
No known diagnosis of dementia; patients with stable treated brain metastases are eligible to participate
-
No known history of central nervous system (CNS) disease (e.g. seizure disorder)
-
No treatment with another antipsychotic agent such as olanzapine, risperidone, quetiapine, clozapine, phenothiazine or butyrophenone =< 30 days prior to registration
-
No chronic phenothiazine administration as an antipsychotic agent (patients may receive prochlorperazine and other phenothiazines as rescue anti-emetic therapy but not within 24 hours prior to registration)
-
No use of amifostine within 7 days prior to registration
-
No radiotherapy within 7 days prior to registration or planned for one week after the current dose of chemotherapy
-
No use of quinolone antibiotic therapy within 7 days prior to registration
-
No chronic alcoholism (as determined by the investigator)
-
No known hypersensitivity to olanzapine
-
No known uncontrolled cardiac arrhythmia, no known uncontrolled congestive heart failure, or no acute myocardial infarction within the previous six months
-
No history of uncontrolled diabetes mellitus, i.e., no diabetic ketoacidosis; within 6 months prior to registration; patients are eligible if they have controlled diabetes on diet, oral agents, and/or insulin
-
Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2
-
Patients must be able to read and comprehend English; local translation, including verbal translation of patient-reported outcomes (PROs) is not permitted
-
Serum creatinine =< 2.0 mg/dL =< 120 days prior to registration
-
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN) =< 120 days prior to registration
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 2 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 3 | Kingman Regional Medical Center | Kingman | Arizona | United States | 86401 |
| 4 | Mayo Clinic Hospital in Arizona | Phoenix | Arizona | United States | 85054 |
| 5 | Mayo Clinic in Arizona | Scottsdale | Arizona | United States | 85259 |
| 6 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 7 | Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | United States | 72401 |
| 8 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 9 | Epic Care-Dublin | Dublin | California | United States | 94568 |
| 10 | Bay Area Breast Surgeons Inc | Emeryville | California | United States | 94608 |
| 11 | Epic Care Partners in Cancer Care | Emeryville | California | United States | 94608 |
| 12 | Tibor Rubin VA Medical Center | Long Beach | California | United States | 90822 |
| 13 | Contra Costa Regional Medical Center | Martinez | California | United States | 94553-3156 |
| 14 | Alta Bates Summit Medical Center - Summit Campus | Oakland | California | United States | 94609 |
| 15 | Bay Area Tumor Institute | Oakland | California | United States | 94609 |
| 16 | Desert Regional Medical Center | Palm Springs | California | United States | 92262 |
| 17 | Epic Care Cyberknife Center | Walnut Creek | California | United States | 94597 |
| 18 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 19 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 20 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 21 | Boulder Community Foothills Hospital | Boulder | Colorado | United States | 80303 |
| 22 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 23 | Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado | United States | 80112 |
| 24 | Cancer Center of Colorado at Sloan's Lake | Denver | Colorado | United States | 80204 |
| 25 | Denver Health Medical Center | Denver | Colorado | United States | 80204 |
| 26 | National Jewish Health-Main Campus | Denver | Colorado | United States | 80206 |
| 27 | The Women's Imaging Center | Denver | Colorado | United States | 80209 |
| 28 | Colorado Blood Cancer Institute | Denver | Colorado | United States | 80218 |
| 29 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 30 | Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | United States | 80218 |
| 31 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 32 | Rocky Mountain Cancer Centers-Rose | Denver | Colorado | United States | 80220 |
| 33 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 34 | Western Surgical Care | Denver | Colorado | United States | 80220 |
| 35 | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | United States | 80113 |
| 36 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 37 | National Jewish Health-Western Hematology Oncology | Golden | Colorado | United States | 80401 |
| 38 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 39 | Grand Valley Oncology | Grand Junction | Colorado | United States | 81505 |
| 40 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 41 | Good Samaritan Medical Center | Lafayette | Colorado | United States | 80026 |
| 42 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 43 | Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | United States | 80124 |
| 44 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 45 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 46 | National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | United States | 80260 |
| 47 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 48 | Middlesex Hospital | Middletown | Connecticut | United States | 06457 |
| 49 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 50 | Mayo Clinic in Florida | Jacksonville | Florida | United States | 32224-9980 |
| 51 | Hawaii Cancer Care - Savio | 'Aiea | Hawaii | United States | 96701 |
| 52 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 53 | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii | United States | 96701 |
| 54 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 55 | The Queen's Medical Center - West Oahu | 'Ewa Beach | Hawaii | United States | 96706 |
| 56 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
| 57 | Island Urology | Honolulu | Hawaii | United States | 96813 |
| 58 | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | United States | 96813 |
| 59 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 60 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 61 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 62 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 63 | Hawaii Diagnostic Radiology Services LLC | Honolulu | Hawaii | United States | 96817 |
| 64 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 65 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 66 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 67 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 68 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859 |
| 69 | Straub Medical Center - Kahului Clinic | Kahului | Hawaii | United States | 96732 |
| 70 | Castle Medical Center | Kailua | Hawaii | United States | 96734 |
| 71 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
| 72 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 73 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 74 | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | United States | 83814 |
| 75 | Walter Knox Memorial Hospital | Emmett | Idaho | United States | 83617 |
| 76 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 77 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 78 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 79 | Kootenai Cancer Clinic | Sandpoint | Idaho | United States | 83864 |
| 80 | Saint Anthony's Health | Alton | Illinois | United States | 62002 |
| 81 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 82 | Loyola Center for Health at Burr Ridge | Burr Ridge | Illinois | United States | 60527 |
| 83 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 84 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 85 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 86 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 87 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 88 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 89 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 90 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 91 | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | United States | 60115 |
| 92 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
| 93 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 94 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 95 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 96 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 97 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 98 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 99 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 100 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 101 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 102 | Loyola Medicine Homer Glen | Homer Glen | Illinois | United States | 60491 |
| 103 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 104 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 105 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 106 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 107 | Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park | Illinois | United States | 60160 |
| 108 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 109 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 110 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 111 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 112 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 113 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 114 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 115 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 116 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 117 | OSF Saint Anthony Medical Center | Rockford | Illinois | United States | 61108 |
| 118 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 119 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 120 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 121 | Southwest Illinois Health Services LLP | Swansea | Illinois | United States | 62226 |
| 122 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 123 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 124 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 125 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
| 126 | Saint Vincent Anderson Regional Hospital/Cancer Center | Anderson | Indiana | United States | 46016 |
| 127 | Memorial Regional Cancer Center Day Road | Mishawaka | Indiana | United States | 46545 |
| 128 | Baptist Health Floyd | New Albany | Indiana | United States | 47150 |
| 129 | Reid Health | Richmond | Indiana | United States | 47374 |
| 130 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 131 | Mary Greeley Medical Center | Ames | Iowa | United States | 50010 |
| 132 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 133 | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 134 | McFarland Clinic PC-Boone | Boone | Iowa | United States | 50036 |
| 135 | Saint Anthony Regional Hospital | Carroll | Iowa | United States | 51401 |
| 136 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 137 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 138 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 139 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 140 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 141 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 142 | JCHC McCreery Cancer Center | Fairfield | Iowa | United States | 52556 |
| 143 | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa | United States | 50501 |
| 144 | Trinity Regional Medical Center | Fort Dodge | Iowa | United States | 50501 |
| 145 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 146 | McFarland Clinic PC-Jefferson | Jefferson | Iowa | United States | 50129 |
| 147 | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa | United States | 50158 |
| 148 | Ottumwa Regional Health Center | Ottumwa | Iowa | United States | 52501 |
| 149 | MercyOne Waterloo Medical Center | Waterloo | Iowa | United States | 50702 |
| 150 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 151 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 152 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 153 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 154 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 155 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 156 | Kansas Institute of Medicine Cancer and Blood Center | Lenexa | Kansas | United States | 66219 |
| 157 | Minimally Invasive Surgery Hospital | Lenexa | Kansas | United States | 66219 |
| 158 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 159 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 160 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 161 | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | United States | 66606 |
| 162 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 163 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 164 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
| 165 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 166 | Baptist Health Corbin | Corbin | Kentucky | United States | 40701 |
| 167 | Baptist Health Hardin | Elizabethtown | Kentucky | United States | 42701 |
| 168 | Baptist Health Lexington | Lexington | Kentucky | United States | 40503 |
| 169 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 170 | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 171 | Saint Claire Regional Medical Center | Morehead | Kentucky | United States | 40351 |
| 172 | Owensboro Health Mitchell Memorial Cancer Center | Owensboro | Kentucky | United States | 42303 |
| 173 | Baptist Health Paducah | Paducah | Kentucky | United States | 42003 |
| 174 | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 175 | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana | United States | 70809 |
| 176 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 177 | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana | United States | 70809 |
| 178 | Medical Center of Baton Rouge | Baton Rouge | Louisiana | United States | 70816 |
| 179 | Louisiana Hematology Oncology Associates | Baton Rouge | Louisiana | United States | 70817 |
| 180 | Our Lady of the Lake Medical Oncology | Baton Rouge | Louisiana | United States | 70817 |
| 181 | Woman's Hospital | Baton Rouge | Louisiana | United States | 70817 |
| 182 | Ochsner High Grove | Baton Rouge | Louisiana | United States | 70836 |
| 183 | Northshore Oncology Associates-Covington | Covington | Louisiana | United States | 70433 |
| 184 | Ochsner Hematology Oncology North Shore - Covington (West Region) | Covington | Louisiana | United States | 70433 |
| 185 | Oncology Center of The South Incorporated | Houma | Louisiana | United States | 70360 |
| 186 | Terrebonne General Medical Center | Houma | Louisiana | United States | 70360 |
| 187 | Ochsner Medical Center Kenner | Kenner | Louisiana | United States | 70065 |
| 188 | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana | United States | 71202 |
| 189 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 190 | Ochsner LSU Health Saint Mary's Medical Center | Shreveport | Louisiana | United States | 71101 |
| 191 | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | United States | 71103 |
| 192 | Anne Arundel Medical Center | Annapolis | Maryland | United States | 21401 |
| 193 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 194 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 195 | Northwest Hospital Center | Randallstown | Maryland | United States | 21133 |
| 196 | UM Saint Joseph Medical Center | Towson | Maryland | United States | 21204 |
| 197 | William E Kahlert Regional Cancer Center/Sinai Hospital | Westminster | Maryland | United States | 21157 |
| 198 | Berkshire Medical Center - Cancer Center | Pittsfield | Massachusetts | United States | 01201 |
| 199 | Mercy Medical Center | Springfield | Massachusetts | United States | 01104 |
| 200 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 201 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 202 | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan | United States | 48114 |
| 203 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 204 | IHA Hematology Oncology Consultants-Canton | Canton | Michigan | United States | 48188 |
| 205 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 206 | Caro Cancer Center | Caro | Michigan | United States | 48723 |
| 207 | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan | United States | 48118 |
| 208 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 209 | Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | United States | 48346 |
| 210 | Newland Medical Associates-Clarkston | Clarkston | Michigan | United States | 48346 |
| 211 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 212 | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan | United States | 48054 |
| 213 | Green Bay Oncology - Escanaba | Escanaba | Michigan | United States | 49829 |
| 214 | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan | United States | 48503 |
| 215 | Genesee Hematology Oncology PC | Flint | Michigan | United States | 48503 |
| 216 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 217 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 218 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 219 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 220 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 221 | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan | United States | 48236 |
| 222 | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 223 | Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods | Michigan | United States | 48236 |
| 224 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 225 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 226 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 227 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 228 | Hope Cancer Clinic | Livonia | Michigan | United States | 48154 |
| 229 | Saint Mary Mercy Hospital | Livonia | Michigan | United States | 48154 |
| 230 | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan | United States | 48044 |
| 231 | Michigan Breast Specialists-Macomb Township | Macomb | Michigan | United States | 48044 |
| 232 | Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | United States | 48453 |
| 233 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 234 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 235 | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | United States | 49444 |
| 236 | 21st Century Oncology-Pontiac | Pontiac | Michigan | United States | 48341 |
| 237 | Hope Cancer Center | Pontiac | Michigan | United States | 48341 |
| 238 | Newland Medical Associates-Pontiac | Pontiac | Michigan | United States | 48341 |
| 239 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 240 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 241 | Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan | United States | 48309 |
| 242 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 243 | Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | United States | 48604 |
| 244 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 245 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 246 | Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights | Michigan | United States | 48312 |
| 247 | Ascension Saint Joseph Hospital | Tawas City | Michigan | United States | 48764 |
| 248 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 249 | Advanced Breast Care Center PLLC | Warren | Michigan | United States | 48088 |
| 250 | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan | United States | 48093 |
| 251 | Macomb Hematology Oncology PC | Warren | Michigan | United States | 48093 |
| 252 | Michigan Breast Specialists-Warren | Warren | Michigan | United States | 48093 |
| 253 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 254 | Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | United States | 48661 |
| 255 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 256 | Huron Gastroenterology PC | Ypsilanti | Michigan | United States | 48106 |
| 257 | IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan | United States | 48197 |
| 258 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 259 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 260 | Minnesota Oncology - Burnsville | Burnsville | Minnesota | United States | 55337 |
| 261 | Cambridge Medical Center | Cambridge | Minnesota | United States | 55008 |
| 262 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 263 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 264 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 265 | Mayo Clinic Health Systems-Mankato | Mankato | Minnesota | United States | 56001 |
| 266 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 267 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 268 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 269 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 270 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 271 | Minneapolis VA Medical Center | Minneapolis | Minnesota | United States | 55417 |
| 272 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 273 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 274 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 275 | Fairview Northland Medical Center | Princeton | Minnesota | United States | 55371 |
| 276 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 277 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 278 | Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 279 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 280 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 281 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 282 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 283 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 284 | Sanford Thief River Falls Medical Center | Thief River Falls | Minnesota | United States | 56701 |
| 285 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 286 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 287 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 288 | Sanford Cancer Center Worthington | Worthington | Minnesota | United States | 56187 |
| 289 | Fairview Lakes Medical Center | Wyoming | Minnesota | United States | 55092 |
| 290 | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | United States | 39705 |
| 291 | Baptist Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
| 292 | Hattiesburg Clinic - Hematology/Oncology Clinic | Hattiesburg | Mississippi | United States | 39401 |
| 293 | Forrest General Hospital / Cancer Center | Hattiesburg | Mississippi | United States | 39404 |
| 294 | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | United States | 38652 |
| 295 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
| 296 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
| 297 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 298 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 299 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 300 | Cox Cancer Center Branson | Branson | Missouri | United States | 65616 |
| 301 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 302 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 303 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 304 | University of Missouri - Ellis Fischel | Columbia | Missouri | United States | 65212 |
| 305 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 306 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 307 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 308 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 309 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 310 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 311 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 312 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 313 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 314 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 315 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 316 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 317 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 318 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 319 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 320 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 321 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 322 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 323 | Mercy Hospital Washington | Washington | Missouri | United States | 63090 |
| 324 | Community Hospital of Anaconda | Anaconda | Montana | United States | 59711 |
| 325 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 326 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 327 | Saint Vincent Frontier Cancer Center | Billings | Montana | United States | 59102 |
| 328 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 329 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 330 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 331 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 332 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 333 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 334 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 335 | Nebraska Hematology and Oncology | Lincoln | Nebraska | United States | 68506 |
| 336 | Cancer Partners of Nebraska - Pine Lake | Lincoln | Nebraska | United States | 68516 |
| 337 | Southeast Nebraska Cancer Center - 68th Street Place | Lincoln | Nebraska | United States | 68516 |
| 338 | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska | United States | 68701 |
| 339 | Great Plains Health Callahan Cancer Center | North Platte | Nebraska | United States | 69101 |
| 340 | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska | United States | 68124 |
| 341 | Oncology Hematology West PC | Omaha | Nebraska | United States | 68130 |
| 342 | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska | United States | 69361 |
| 343 | Carson Tahoe Regional Medical Center | Carson City | Nevada | United States | 89703 |
| 344 | Cancer and Blood Specialists-Henderson | Henderson | Nevada | United States | 89052 |
| 345 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 346 | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | United States | 89052 |
| 347 | Las Vegas Cancer Center-Henderson | Henderson | Nevada | United States | 89052 |
| 348 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 349 | 21st Century Oncology-Henderson | Henderson | Nevada | United States | 89074 |
| 350 | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | United States | 89074 |
| 351 | Las Vegas Urology - Green Valley | Henderson | Nevada | United States | 89074 |
| 352 | Las Vegas Urology - Pebble | Henderson | Nevada | United States | 89074 |
| 353 | Urology Specialists of Nevada - Green Valley | Henderson | Nevada | United States | 89074 |
| 354 | Las Vegas Urology - Pecos | Las Vegas | Nevada | United States | 89074 |
| 355 | Desert West Surgery | Las Vegas | Nevada | United States | 89102 |
| 356 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 357 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 358 | Hope Cancer Care of Nevada | Las Vegas | Nevada | United States | 89103 |
| 359 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 360 | Urology Specialists of Nevada - Central | Las Vegas | Nevada | United States | 89106 |
| 361 | 21st Century Oncology | Las Vegas | Nevada | United States | 89109 |
| 362 | HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | United States | 89109 |
| 363 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109 |
| 364 | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | United States | 89113 |
| 365 | Las Vegas Prostate Cancer Center | Las Vegas | Nevada | United States | 89113 |
| 366 | Las Vegas Urology - Sunset | Las Vegas | Nevada | United States | 89113 |
| 367 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 368 | 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada | United States | 89128 |
| 369 | Ann M Wierman MD LTD | Las Vegas | Nevada | United States | 89128 |
| 370 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 371 | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | United States | 89128 |
| 372 | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada | United States | 89128 |
| 373 | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada | United States | 89128 |
| 374 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 375 | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 376 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 377 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
| 378 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 379 | Summerlin Hospital Medical Center | Las Vegas | Nevada | United States | 89144 |
| 380 | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | United States | 89148-2405 |
| 381 | 21st Century Oncology-Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 382 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 383 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 384 | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada | United States | 89148 |
| 385 | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | United States | 89149 |
| 386 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 387 | University Cancer Center | Las Vegas | Nevada | United States | 89169 |
| 388 | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | United States | 89048 |
| 389 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 390 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 391 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 392 | Hematology Oncology Associates of Central New York-Auburn | Auburn | New York | United States | 13021 |
| 393 | Northwell Health Imbert Cancer Center | Bay Shore | New York | United States | 11706 |
| 394 | James J Peters VA Medical Center | Bronx | New York | United States | 10468 |
| 395 | New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | United States | 11215 |
| 396 | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | United States | 13057 |
| 397 | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York | United States | 14905 |
| 398 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 399 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
| 400 | NYP/Weill Cornell Medical Center | New York | New York | United States | 10065 |
| 401 | Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York | United States | 13215 |
| 402 | AdventHealth Infusion Center Asheville | Asheville | North Carolina | United States | 28803 |
| 403 | AdventHealth Infusion Center Haywood | Clyde | North Carolina | United States | 28721 |
| 404 | Cape Fear Valley Health System | Fayetteville | North Carolina | United States | 28304 |
| 405 | CaroMont Regional Medical Center | Gastonia | North Carolina | United States | 28054 |
| 406 | AdventHealth Hendersonville | Hendersonville | North Carolina | United States | 28792 |
| 407 | CarolinaEast Medical Center | New Bern | North Carolina | United States | 28561 |
| 408 | CarolinaEast Oncology and Hematology Associates | New Bern | North Carolina | United States | 28562 |
| 409 | Marion L Shepard Cancer Center at Vidant Beaufort Hospital | Washington | North Carolina | United States | 27889 |
| 410 | AdventHealth Infusion Center Weaverville | Weaverville | North Carolina | United States | 28787 |
| 411 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 412 | Sanford South University Medical Center | Fargo | North Dakota | United States | 58103 |
| 413 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 414 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 415 | Altru Cancer Center | Grand Forks | North Dakota | United States | 58201 |
| 416 | Aultman Alliance Community Hospital | Alliance | Ohio | United States | 44601 |
| 417 | Indu and Raj Soin Medical Center | Beavercreek | Ohio | United States | 45431 |
| 418 | Saint Elizabeth Boardman Hospital | Boardman | Ohio | United States | 44512 |
| 419 | Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 420 | Dayton Physicians LLC-Miami Valley South | Centerville | Ohio | United States | 45459 |
| 421 | Miami Valley Hospital South | Centerville | Ohio | United States | 45459 |
| 422 | Oncology Hematology Care Inc-Kenwood | Cincinnati | Ohio | United States | 45236 |
| 423 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 424 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 425 | Dayton Physician LLC-Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 426 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 427 | Dayton Veterans Affairs Medical Center | Dayton | Ohio | United States | 45428 |
| 428 | Armes Family Cancer Center | Findlay | Ohio | United States | 45840 |
| 429 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 430 | Orion Cancer Care | Findlay | Ohio | United States | 45840 |
| 431 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 432 | Dayton Physicians LLC-Atrium | Franklin | Ohio | United States | 45005 |
| 433 | Dayton Physicians LLC-Wayne | Greenville | Ohio | United States | 45331 |
| 434 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 435 | Greater Dayton Cancer Center | Kettering | Ohio | United States | 45409 |
| 436 | First Dayton Cancer Care | Kettering | Ohio | United States | 45420 |
| 437 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 438 | Springfield Regional Cancer Center | Springfield | Ohio | United States | 45504 |
| 439 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 440 | Dayton Physicians LLC-Upper Valley | Troy | Ohio | United States | 45373 |
| 441 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 442 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
| 443 | Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | United States | 44501 |
| 444 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 445 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 446 | Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | United States | 97814 |
| 447 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 448 | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | United States | 97914 |
| 449 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 450 | Legacy Meridian Park Hospital | Tualatin | Oregon | United States | 97062 |
| 451 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 452 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 453 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 454 | Pocono Medical Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 455 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 456 | Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 457 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 458 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 459 | Phoenixville Hospital | Phoenixville | Pennsylvania | United States | 19460 |
| 460 | Pottstown Hospital | Pottstown | Pennsylvania | United States | 19464 |
| 461 | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 462 | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | United States | 18840 |
| 463 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 464 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 465 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 466 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 467 | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | United States | 29316 |
| 468 | Ralph H Johnson VA Medical Center | Charleston | South Carolina | United States | 29401 |
| 469 | Prisma Health Cancer Institute - Laurens | Clinton | South Carolina | United States | 29325 |
| 470 | Prisma Health Cancer Institute - Easley | Easley | South Carolina | United States | 29640 |
| 471 | Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | United States | 29440 |
| 472 | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | United States | 29605 |
| 473 | Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 474 | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | United States | 29605 |
| 475 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 476 | Self Regional Healthcare | Greenwood | South Carolina | United States | 29646 |
| 477 | Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 478 | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 479 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 480 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 481 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 482 | Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | United States | 38017 |
| 483 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 484 | Houston Methodist San Jacinto Hospital | Baytown | Texas | United States | 77521 |
| 485 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 486 | Methodist Willowbrook Hospital | Houston | Texas | United States | 77070 |
| 487 | Houston Methodist West Hospital | Houston | Texas | United States | 77094 |
| 488 | Houston Methodist Saint John Hospital | Nassau Bay | Texas | United States | 77058 |
| 489 | Houston Methodist Sugar Land Hospital | Sugar Land | Texas | United States | 77479 |
| 490 | Houston Methodist The Woodlands Hospital | The Woodlands | Texas | United States | 77385 |
| 491 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 492 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 493 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 494 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 495 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 496 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 497 | Riverton Hospital | Riverton | Utah | United States | 84065 |
| 498 | Dixie Medical Center Regional Cancer Center | Saint George | Utah | United States | 84770 |
| 499 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 500 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 501 | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont | United States | 05602 |
| 502 | University of Vermont Medical Center | Burlington | Vermont | United States | 05401 |
| 503 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
| 504 | Augusta Health Center for Cancer and Blood Disorders | Fishersville | Virginia | United States | 22939 |
| 505 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 506 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 507 | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington | United States | 98335 |
| 508 | Jefferson Healthcare | Port Townsend | Washington | United States | 98368 |
| 509 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 510 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 511 | MultiCare Deaconess Cancer and Blood Specialty Center - Valley | Spokane Valley | Washington | United States | 99216 |
| 512 | MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington | United States | 99204 |
| 513 | MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington | United States | 99218 |
| 514 | Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | United States | 98405 |
| 515 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 516 | Legacy Cancer Institute Medical Oncology and Day Treatment | Vancouver | Washington | United States | 98684 |
| 517 | Legacy Salmon Creek Hospital | Vancouver | Washington | United States | 98686 |
| 518 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 519 | Edwards Comprehensive Cancer Center | Huntington | West Virginia | United States | 25701 |
| 520 | Saint Mary's Medical Center | Huntington | West Virginia | United States | 25702 |
| 521 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 522 | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
| 523 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 524 | Mayo Clinic Health System-Eau Claire Clinic | Eau Claire | Wisconsin | United States | 54701 |
| 525 | Mayo Clinic Health System Eau Claire Hospital-Luther Campus | Eau Claire | Wisconsin | United States | 54703 |
| 526 | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin | United States | 54937 |
| 527 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 528 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 529 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 530 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 531 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 532 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 533 | Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin | United States | 54601 |
| 534 | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin | United States | 54848 |
| 535 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54221 |
| 536 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 537 | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin | United States | 54143 |
| 538 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 539 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 540 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 541 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 542 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 543 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 544 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 545 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 546 | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 547 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 548 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 549 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 550 | HSHS Saint Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 551 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 552 | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin | United States | 54482 |
| 553 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
| 554 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 555 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 556 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 557 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 558 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 559 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 560 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 561 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 562 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 563 | Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | United States | 82001 |
| 564 | Billings Clinic-Cody | Cody | Wyoming | United States | 82414 |
| 565 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 566 | FHP Health Center-Guam | Tamuning | Guam | 96913 |
Sponsors and Collaborators
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
Investigators
- Study Chair: Rudolph Navari, MD, PhD, FACP, University of Alabama at Birmingham
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT03578081
Other Study ID Numbers:
- A221602
- NCI-2017-02410
- UG1CA189823
First Posted:
Jul 5, 2018
Last Update Posted:
Jan 10, 2022
Last Verified:
Jan 1, 2022
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: