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Malnutrition Using GLIM Criteria and Comparing CT and BIA for Muscle Mass Measurement

Sponsor
Klinikum St. Georg gGmbH (Other)
Overall Status
Completed
CT.gov ID
NCT05174715
Collaborator
(none)
260
Enrollment
42.4
Actual Duration (Months)

Study Details

Study Description

Brief Summary

Evaluation of malnutrition with the help of the GLIM criteria. Muscle mass measurement, as recommended in the GLIM criteria was done with the help of abdominal CT scan and BIA. Both methods were compared and their association to the clinical outcome was assessed.

Condition or Disease Intervention/Treatment Phase
  • Other: BIA

Detailed Description

We retrospectively analysed 260 patients undergoing major abdominal surgery between January 2017 and December 2019. Patients were prospectively screened and assessed for malnutrition with Nutritional Risk Score (NRS) and Subjective Global assessment (SGA). Body composition was analysed with CT scan and BIA within 30 days before surgery. GLIM criteria were retrospectively determined referring to the Fat free Mass from BIA (FFMBIA) and Muscle Mass from axial CT scan at lumbar level 3 (MMCT). The prevalence of GLIM - malnutrition according to BIA and CT was evaluated. Multivariate logistic regression analysis was used to determine association between malnutrition and outcome parameters. ROC-curves specified sensitivity and specificity of the different tools and areas under the curve were calculated.

Study Design

Study Type:
Observational
Actual Enrollment :
260 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Evaluation of Malnutrition in Patients Undergoing Major Abdominal Surgery Using GLIM Criteria and Comparing CT and BIA for Muscle Mass Measurement
Actual Study Start Date :
Jan 1, 2017
Actual Primary Completion Date :
Dec 31, 2019
Actual Study Completion Date :
Jul 15, 2020

Outcome Measures

Primary Outcome Measures

  1. overall complications [31 days POD]

    all complications perioperatively including surgical side infections, anastomic leakage, sepsis

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Inclusion Criteria:

  • age above 18 years

  • BIA and CT scan was available within 31 days before surgery

  • patients undergoing major abdominal surgery for gastrointestinal cancer

Exclusion Criteria:

  • patients who were not able to agree to the participation

  • missing assessment of the nutritional status

  • leck of quality of the CT scan

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Klinikum St. Georg gGmbH

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Maria Wobith, Principle Investigator, Klinikum St. Georg gGmbH
ClinicalTrials.gov Identifier:
NCT05174715
Other Study ID Numbers:
  • GLIMCTBIA
First Posted:
Jan 3, 2022
Last Update Posted:
Jan 14, 2022
Last Verified:
Dec 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Maria Wobith, Principle Investigator, Klinikum St. Georg gGmbH
malnutrition, sarcopenia, GLIM criteria
Additional relevant MeSH terms:
Malnutrition

Study Results

No Results Posted as of Jan 14, 2022