Managing Bacterial Pneumonia in Children Without Antimicrobials
Study Details
Study Description
Brief Summary
Retrospective cohort analysis of children hospitalized for pneumonia comparing disease severity on admission, clinical course, treatment and outcomes and prospective telephone based Follow-Up assessement.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The investigators will conduct a retrospective cohort analysis of children hospitalized for pneumonia at the Filderklinik between December 2006 and November 2010. The Bacterial Pneumonia Score, a validated composite laboratory, clinical and radiologic score developed by Moreno et al, will be retrospectively applied to define cases as either viral or bacterial pneumonia. The investigators will compare disease severity on admission, clinical course, and outcomes (in terms of complications, length of stay and readmission rates) between antimicrobial and non-antimicrobial managed bacterial pneumonia cases. Long-term Follow-Up will be assessed by telephone interviews with the parents.
Study Design
Outcome Measures
Primary Outcome Measures
- Cure rate of non-antimicrobial management of bacterial pneumonia [Between admission and 3 months after discharge]
Cure rate of non-antimicrobial management of bacterial pneumonia (in the following and in the final publication, the term "bacterial pneumonia" will be used for children who fulfill the Moreno criteria for pneumonia): % of children managed without antimicrobials since admission, without subsequent need for antimicrobials or readmission.
- Medical complication rate [Between admission and 3 months after discharge]
Medical complication rate among children with bacterial pneumonia, treated with or without antimicrobials
- Length of hospital stay [Between admission and 3 months after discharge]
Length of hospital stay for children with bacterial pneumonia, managed with or without antimicrobials
- Readmission rate [7 - 10 years after hospitalization]
Readmission rate for pneumonia among children with bacterial pneumonia, managed with or without antimicrobials
- Temperature normalization [Between admission and 3 months after discharge]
Days to temperature normalization (< 38°C) in children with bacterial pneumonia, managed with or without antimicrobials
- Days of supplemental oxygen need [Between admission and 3 months after discharge]
Days of supplemental oxygen need in children with bacterial pneumonia, managed with or without antimicrobials
Secondary Outcome Measures
- Changes in respiratory rate [Between admission and 3 months after discharge]
Changes in respiratory rate as an indicator for pulmonary infection
- Changes in Bacterial Pneumonia Score [Between admission and 3 months after discharge]
Changes in Bacterial Pneumonia Score as an indicator for pulmonary infection
- Changes in oxygen saturation [Between admission and 3 months after discharge]
Changes in oxygen saturation as an indicator for pulmonary infection
- Changes in CRP [Between admission and 3 months after discharge]
Changes in CRP as an indicator for infection
- Changes in leukocyte count [Between admission and 3 months after discharge]
Changes in leukocyte count as an indicator for infection
- Changes in pH [Between admission and 3 months after discharge]
Changes in pH as an indicator for respiratory distress
- Changes in pCO2 [Between admission and 3 months after discharge]
Changes in pCO2 as an indicator for respiratory distress
- Rate of chronic and acute-infectious co-morbidities [Day of admission]
Rate of chronic and acute-infectious co-morbidities on admission in children with bacterial pneumonia, subsequently managed with or without antimicrobials
- Utilization rate of a package of complementary treatment measures [Between admission and 3 months after discharge]
Utilization rate of a package of complementary treatment measures from anthroposophic medicine (including oral medications, inhalation and external nursing applications) in children managed with or without antimicrobials
- Antimicrobial treatment rate in children with viral pneumonia [Between admission and 3 months after discharge]
Antimicrobial treatment rate in children classified as viral pneumonia by Bacterial Pneumonia Score
- Number of patients treated with antipyretics [Between admission and 3 months after discharge]
Number of patients treated with antipyretics
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Hospital admission at the pediatric department of the Filderklinik.
-
Admission diagnosis pneumonia (ICD J12.0, J12.1, J12.8, J12.9, J14, J15.1, J15.6, J15.7, J15.8, J15.9, J16.8, J18.0, J18.1, J18.8, J18.9 - all 12s, 15s, 16s, 18s)
Exclusion Criteria:
- None
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Arcim Institute | Filderstadt | Baden-Württemberg | Germany | 70794 |
Sponsors and Collaborators
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PKA_01