Measurement of Noradrenaline Concentrations Using Different Dilution Methods

Sponsor

University Hospital, Strasbourg, France (Other)

Overall Status

Recruiting

CT.gov ID

NCT04772599

Collaborator

(none)

Enrollment

Location

4.3

Anticipated Duration (Months)

11.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial preparation is increasingly common in the operating room ("baby-noradrenaline").

In addition, dilution errors are potentially serious for the patient (hypertensive peak) The preparation of precise dilutions is an important factor for the safe use of this medically In this study, the investigators wish to compare the dilution method of the protocol with another method of preparation (left to the free choice of the participant).

Condition or Disease	Intervention/Treatment	Phase
Arterial Hypertension

Study Design

Study Type:

Observational

Anticipated Enrollment :

50 participants

Observational Model:

Other

Time Perspective:

Prospective

Official Title:

Measurement of Noradrenaline Concentrations Using Different Dilution Methods

Actual Study Start Date :

Feb 21, 2021

Anticipated Primary Completion Date :

Jul 1, 2021

Anticipated Study Completion Date :

Jul 1, 2021

Outcome Measures

Primary Outcome Measures

Measurement of noradrenaline concentrations using different dilution methods [1 hour after the preparation of the noradrenaline solutions]
Measurement methods: High performance liquid chromatography Measurement of the concentration of noradrenaline in the biochemical laboratory of the University Hospitals of Strasbourg

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Inclusion criteria:

Adult person,
Employee of Strasbourg University Hospitals,
Likely to have to prepare anesthesia drugs in the operating room (intern, hospital student, IADE, IADE student)