Measures of Mitochondria Dysfunction in PD
Study Details
Study Description
Brief Summary
This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
The goal of this study is to identify the unique signature of bioenergetic markers and mitochondrial (dys)function in muscle of individuals with PD, who are 65-85 of age, read and speak English, have a Hoehn & Yahr score between 2 and 3 (bilateral disease, not severely disabled) and have a clinical diagnosis of PD. Bioenergetic markers and muscle functional properties will be compared to a control dataset collected over the last few years from healthy elderly subjects in the same age range to provide a foundation for future intervention studies.
Study Design
Outcome Measures
Primary Outcome Measures
- ATPmax [baseline]
Maximal mitochondrial ATP production rates measured by magnetic resonance spectroscopy
- NAD(H) metabolites [baseline]
Measurement of relative NAD(H) metabolite concentrations in resting skeletal muscle by magnetic resonance spectroscopy
- Muscle force and endurance [baseline]
Maximum voluntary contraction (MVC) force in Newtons and fatigue resistance assessed by the ability to maintain repeated contractions at 70% MVC will be measured in the hand (flexor digitorum interroseus) and leg (tibialis anterior) using isometric contractions in a custom made apparatus.
Secondary Outcome Measures
- Mitochondrial metabolites [baseline]
Separate measurement of NAD(H) metabolite concentrations in cytosol and mitochondria by magnetic resonance spectroscopy in resting skeletal muscle
- Relationship between self report function and mitochondrial energetics [baseline]
Correlation between self report of fatigue, balance, and muscle pain (PRO-PD) with ATPmax rates and NAD(H) metabolite concentrations measured using magnetic resonance spectroscopy.
- Relationship between clinical assessment and mitochondrial energetics [baseline]
Correlation between UPDRS with ATPmax and NAD(H) metabolites
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 65-85 years.
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Ability to attend a 3-hour study visit in Seattle, WA.
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Ability to read and speak English.
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Hoehn & Yahr Stage 2-3. (bilateral disease, not severely disabled.)
Exclusion Criteria:
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Any contra-indication to magnetic resonance imaging
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A history of epilepsy, stroke, brain surgery, or structural brain disease.
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The presence of other serious illnesses
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Current or recent enrollment in a clinical trial involving an investigational product or device.
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Supplementation with NAD, nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and other nutraceuticals designed to target NAD for 30 days prior to baseline study visit.
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Current drug or alcohol use or dependence.
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Inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.)
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Acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
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Right limb tremor or dyskinesia that cannot be comfortably controlled for 90 minutes.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University of Washington | Seattle | Washington | United States | 98109 |
Sponsors and Collaborators
- University of Washington
- Michael J. Fox Foundation for Parkinson's Research
Investigators
- Principal Investigator: David Marcinek, PhD, University of Washington
- Principal Investigator: Laurie Mischley, ND, MPH, PhD, Bastyr University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- STUDY00007024