Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef

• Sponsor: Kasper Dideriksen (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT02732353
• Collaborator: (none)
• Enrollment: 10
• Location: 1
• Arms: 2
• Duration (Months): 15.9
• Patients Per Site Per Month: 0.6

Study Details

Study Description

Brief Summary

To measure the absorption kinetics and postprandial amino acid availability after ingestion of minced beef compared with hydrolyzed beef in young males. Moreover, the basal muscle protein synthesis and the postprandial muscle protein synthetic response to minced beef and hydrolyzed beef ingestion are measured in young males. The postprandial muscle protein synthetic response is measured and compared during the early postprandial period (0-3 hours) after ingestion of the two meat products.

Condition or Disease	Intervention/Treatment	Phase
Meat Protein Supplements; Protein Absorption and Amino Acid Availability; Muscle Protein Synthesis	Dietary Supplement: Minced beef; Dietary Supplement: Hydrolyzed beef	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 10 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: None (Open Label)
• Primary Purpose: Health Services Research
• Official Title: Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef
• Study Start Date: Nov 1, 2016
• Anticipated Primary Completion Date: Mar 1, 2018
• Anticipated Study Completion Date: Mar 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Minced beef Minced beef	Dietary Supplement: Minced beef; Cow meat protein supplement
Experimental: Hydrolyzed beef Hydrolyzed beef	Dietary Supplement: Hydrolyzed beef; Cow meat protein supplement

Outcome Measures

Primary Outcome Measures

1. Change in skeletal muscle protein fractional synthetic rate [During the postprandial period (0-3 hrs).]

   The fractional synthetic rate of skeletal muscle proteins (%/h) measured during the overnight fasted state and the postprandial state.

Secondary Outcome Measures

1. Protein absorption [During the postprandial period (0-3 hrs).]

   The change in venous plasma ring-2H5-phenylalanine enrichment after ingestion of meat protein, reflects the protein absorption from the meat protein products.

2. Plasma amino acid concentration [During the postprandial period (0-3 hrs).]

   Change in venous plasma amino acid concentration after ingestion of meat protein.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 30 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy

• Non-obese (BMI<30)

Exclusion Criteria:

• Chronic medical disease

• 5 hour of exercise weekly, except light activities such as stretching/gymnastics and bike-riding/walking as transportation

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Bispebjerg Hospital	Copenhagen NV		Denmark	2400

Sponsors and Collaborators

• Kasper Dideriksen

Investigators

• Principal Investigator: Kasper Dideriksen, PhD, Bispebjerg Hospital
• Principal Investigator: Lars Holm, PhD, Bispebjerg Hospital
• Principal Investigator: Søren Reitelseder, PhD, Bispebjerg Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Kasper Dideriksen, PhD, Post doc, Bispebjerg Hospital
• ClinicalTrials.gov Identifier: NCT02732353
• Other Study ID Numbers: H-15012327
• First Posted: Apr 8, 2016
• Last Update Posted: Nov 8, 2016
• Last Verified: Nov 1, 2016

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No

Study Results

No Results Posted as of Nov 8, 2016