Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia
Study Details
Study Description
Brief Summary
The association of conscious sedation vs. general anesthesia in ischemic stroke with posterior circulation occlusions undergoing endovascular therapy, is istill unknown.
No prospective or clinical trials have studied this effect on posterior circulation strokes.
The choice of anesthetic regimen is ussually depending on local stroke-team protocols or neurointerventional preference.
MORPHEUS Stroke Registry is a prospective multicentre observational study that investigates the association between anestheisa and functional outcome in patients with posterior circulation large vessel occlusion treated endovascularly.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Conscious Sedation
|
Procedure: Type of anesthesia choice
Use of conscious sedation vs. general anesthesia
|
| General Anesthesia
|
Procedure: Type of anesthesia choice
Use of conscious sedation vs. general anesthesia
|
Outcome Measures
Primary Outcome Measures
- Functional independence at 3 months [3 months]
Rate of functional independence (modified Rankin Scale 0-2) at 3 months
Secondary Outcome Measures
- First Pass Effect [1 day]
Rate of complete successful recanalization (mTICI 2c-3) with one single pass of device
- Mortality [3 months]
Rate of mortality at 3 months
- Successfull recanalization and complete recanalization according to endovascular technique [1 day, revascularization grade will be assessed]
Rate of mTICI 3 and mTICI 2b-3 according to endovascular technique (contact aspiration, stentriever or combined)
- Number of passes [1 day, number of device passes will be assessed]
Number of intracranial thrombectomy passes to achieve final reperfusion
- NIHSS at 24 hours [24 hours]
Rate of neurological status at 24 hours, dramatical neurological improvement after mechanical thrombectomy
- Type of anesthesic and outcome [3 months]
Study of the type of anesthesic choice and complications, time of intubation and
- Length of stentretriever and recanalization [1 day, stentretriever type will be assessed]
Rates of FPE and succesful recanalization according to the length of stentretriever used
- Arterial hypotension during anesthesic induction and outcome [3 months]
Study of arterial hypotension during anesthesic induction and outcome
- Bridging therapy and neurologial/functional outcomes [1 day, type of previous fibrinolytic use will be assessed]
To study the association between bridging therapy and reperfussion rates, neurological status and funtional independence at 3 months.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Subject aged ≥ 18 years
-
Evidence of posterior arterial occlussion (basilar artery, intracranial vertebral artery and posterior cerebral artery)
-
Patients eligible for mechanical thrombectomy
Exclusion Criteria:
-
Patient's refusal to participate
-
Arterial recanalization prior to endovascular thrombectomy attempt
-
Patient unable to present or be available for follow-up
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Universitari Doctor Josep Trueta de Girona | Girona | Spain | 17007 |
Sponsors and Collaborators
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MORPHEUS STROKE REGISTRY