Proportional Ventilation and Ventilatory Synchronism
Sponsor
Hospices Civils de Lyon (Other)
Overall Status
Unknown status
CT.gov ID
NCT00133939
Collaborator
(none)
10
1
Study Details
Study Description
Brief Summary
Synchronism of gas flow delivered by the ventilator and muscular effort of the patient will be studied during two kinds of ventilation. The first one is the proportional assisted ventilation during which the gas flow is theoretically adapted to the patient's muscular effort within the breath. The second is the pressure support ventilation during which the gas flow is delivered to maintain the inspiratory pressure stable. The hypothesis is that the first mode allows a better synchronism.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Allocation:
Non-Randomized
Intervention Model:
Crossover Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Proportional Ventilation and Ventilatory Synchronism
Outcome Measures
Primary Outcome Measures
- Time lag between the onset of diaphragmatic electromyogram (EMG) signal and the zero crossing of the inspiratory flow, over five minutes []
Secondary Outcome Measures
- Number per minute of failing breaths: breath with muscular effort without any inspiratory flow []
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- Patients undergoing partial ventilatory support
Exclusion Criteria:
- Patients failing the weaning process
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hôpital de la Croix-Rousse | Lyon | France | 69317 |
Sponsors and Collaborators
- Hospices Civils de Lyon
Investigators
- Principal Investigator: Jean-Paul VIALE, MD, PhD, Hospices Civils de Lyon
Study Documents (Full-Text)
None provided.More Information
Publications
- Ganne O, Abisseror M, Menault P, Malhière S, Chambost V, Charpiat B, Ganne C, Viale JP. Low-dose ketamine failed to spare morphine after a remifentanil-based anaesthesia for ear, nose and throat surgery. Eur J Anaesthesiol. 2005 Jun;22(6):426-30.
- Méchet I, Lhuillier F, Blanchet MC, Pouyet M, Viale JP, Goudable J, Annat G, Scoazec JY, Boillot O, Liotard D, Merle E, Delafosse B. Liver function during extracorporeal whole liver perfusion in a pig model of acute ischemic liver failure. ASAIO J. 2004 Sep-Oct;50(5):503-11.
Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00133939
Other Study ID Numbers:
- 2004.359
First Posted:
Aug 24, 2005
Last Update Posted:
Apr 27, 2007
Last Verified:
Apr 1, 2007