Mechanism for Exercise to Delay Cardiac Aging

Sponsor
Xiao-dong Zhuang (Other)
Overall Status
Completed
CT.gov ID
NCT06031675
Collaborator
(none)
40
1
3.7
10.9

Study Details

Study Description

Brief Summary

The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(VILPA) within a healthy population.

The main question it aims to answer is:

[1] Does VILPA yield effective outcomes?

Throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. The efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.

Condition or Disease Intervention/Treatment Phase
  • Other: Vigorous intermittent lifestyle physical activity

Study Design

Study Type:
Observational
Actual Enrollment :
40 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
The αKlotho Protein-mediated NLRP3/Caspase-1/GSDMD Pathway Counteracts Myocardial Stunning: a Novel Mechanism for Exercise to Delay Cardiac Aging
Actual Study Start Date :
May 12, 2023
Actual Primary Completion Date :
Jul 10, 2023
Actual Study Completion Date :
Sep 1, 2023

Arms and Interventions

Arm Intervention/Treatment
intervention group

The intervention measures encompass the implementation of simulated vigorous intermittent lifestyle physical activity for all participants. The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.

Other: Vigorous intermittent lifestyle physical activity
The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.

Outcome Measures

Primary Outcome Measures

  1. Isometric Strength Test [15 minutes]

    Isokinetic muscle strength testing with the Isomed 2000

  2. Surface electromyography [30 minutes]

  3. Exercise Flat Test [30 minutes]

    cardiopulmonary function

Secondary Outcome Measures

  1. Fasting glucose [5 minutes]

  2. Blood lipid [5 minutes]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  1. Healthy Adults

  2. No exercise habits (more than 3 months)

Exclusion Criteria:
  1. Exercising ≥ 3 times per week;

  2. the presence of chronic diseases, such as hypertension, hyperglycemic states, etc;

  3. have conducted an exercise program in the past three months.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Guangdong Pharmaceutical University Guangzhou Guangdong China 510006

Sponsors and Collaborators

  • Xiao-dong Zhuang

Investigators

  • Study Director: Lizhen Liao, PhD, Department of Health, Guangdong Pharmaceutical University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Xiao-dong Zhuang, Clinical Professor, Sun Yat-sen University
ClinicalTrials.gov Identifier:
NCT06031675
Other Study ID Numbers:
  • K0001
First Posted:
Sep 11, 2023
Last Update Posted:
Sep 11, 2023
Last Verified:
Sep 1, 2023
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Xiao-dong Zhuang, Clinical Professor, Sun Yat-sen University

Study Results

No Results Posted as of Sep 11, 2023