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Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

Sponsor
Helsinki University Central Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT01968148
Collaborator
(none)
30
Enrollment
2
Locations
20.9
Duration (Months)
15
Patients Per Site
0.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).

Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.

Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    30 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
    Study Start Date :
    Nov 1, 2013
    Actual Primary Completion Date :
    Jul 30, 2015
    Actual Study Completion Date :
    Jul 30, 2015

    Outcome Measures

    Primary Outcome Measures

    1. Change in level of insulin [60 minutes]

    2. Change in level of glucagon [60 minutes]

    Secondary Outcome Measures

    1. Blood cortisol level [60 minutes after ROSC]

    2. Blood interleukin-6 level [60 minutes after ROSC]

    3. Change in blood glucose level [60 minutes]

    4. Change in level of GLP-1 [60 minutes]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • age ≥18 years

    • witnessed cardiac arrest

    • interval form emergency call to return of spontaneous circulation 10-45 minutes

    Exclusion Criteria:

    • severe pre-arrest disability leading to withdrawing treatment in prehospital phase

    • no concent from next of kin

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Helsinki Emergency Medical Services Helsinki Finland
    2 Helsinki Area Helicopter Emergency Medical Services Vantaa Finland

    Sponsors and Collaborators

    • Helsinki University Central Hospital

    Investigators

    • Principal Investigator: Jouni Nurmi, MD, PhD, Helsinki University Central Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Jouni Nurmi, MD, MD, PhD, Helsinki University Central Hospital
    ClinicalTrials.gov Identifier:
    NCT01968148
    Other Study ID Numbers:
    • 357/13/03/12/2012 § 205
    First Posted:
    Oct 23, 2013
    Last Update Posted:
    Mar 13, 2018
    Last Verified:
    Mar 1, 2018
    Keywords provided by Jouni Nurmi, MD, MD, PhD, Helsinki University Central Hospital
    glucose
    cardiac arrest
    resuscitation
    insulin
    GLP-1
    Additional relevant MeSH terms:
    Heart Arrest
    Out-of-Hospital Cardiac Arrest
    Hyperglycemia

    Study Results

    No Results Posted as of Mar 13, 2018