MICARI: Multiparametric Magnetic Resonance Imaging (MRI) in Medullary Sponge Kidney

• Sponsor: Hospices Civils de Lyon (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT05682053
• Collaborator: (none)
• Enrollment: 40
• Location: 1
• Arms: 2
• Anticipated Duration (Months): 24
• Patients Per Site Per Month: 1.7

Study Details

Study Description

Brief Summary

Background :

Medullary sponge kidney disease is a congenital disorder caracterised by tubular ectasia and cystic dilatation of the collecting ducts in the pericalyceal region of the renal pyramids, which can lead to nephrolithiasis and frequently associated with impaired tubular function such as distal renal tubular acidosis.

The disease knowledge is limited, especially about origin, diagnosis, and physiopathology of the disease.

The disease is associated with impaired tubular function such as distal renal tubular acidosis, hypocitraturia, hypercalciuria, which suggest altered kidney medulla function.

Multiparametric MRI may provide further informations about the physiopathology and help in earlier diagnosis of the medullary sponge kidney.

Objective :

The aim of this study is to test the hypothesis that early kidney medulla function alteration in medullary sponge kidney can be detected and characterised with multiparametric MRI. We are expecting to see in medullary sponge kidney a decreased oxygenation content in BOLD MRI (Blood oxygenation level dependent magnetic resonance imaging), and decreased ADC (Apparent diffusion coefficient) value in the medulla.

Design :

A monocentric prospective case/control study will be conducted in adults with medullary sponge kidney. Controls are adults patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone attending a renal exploration.

After a screening visit, patients included will be evaluated on one day with lithiasis assessment and measurement of glomerular filtration (Urinary collection of the last 24 hours, Urine sample, Blood sample) and they will perform multiparametric magnetic resonance imaging of the kidneys.

Condition or Disease	Intervention/Treatment	Phase
Medullary Sponge Kidney	Diagnostic Test: Multiparametic MRI	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 40 participants
• Allocation: Non-Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Diagnostic
• Official Title: Multiparametric MRI Imaging of Medullary Sponge Kidney
• Anticipated Study Start Date: Jan 15, 2023
• Anticipated Primary Completion Date: Jan 16, 2025
• Anticipated Study Completion Date: Jan 16, 2025

Arms and Interventions

Arm	Intervention/Treatment
Other: patients with medullary sponge kidney Patients with medullary sponge kidney attending medical consultation	Diagnostic Test: Multiparametic MRI; patients will have a Multiparametric MRI
Other: Patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone Patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone attending a renal exploration.	Diagnostic Test: Multiparametic MRI; patients will have a Multiparametric MRI

Outcome Measures

Primary Outcome Measures

1. Comparaison of R2* values measured by BOLD MRI beetween medullary sponge kidney patients and controls. [Day 0]

   Comparaison of R2* values measured by BOLD MRI between medullary sponge kidney patients and controls. R2* is related to the level of tissue deoxyhemoglobin, which reflect tissue oxygenation. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation.

Secondary Outcome Measures

1. Comparaison of ADC value measured by diffusion-weighted MRI beetween medullary sponge kidney patients and controls. [Day 0]

   Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive method sensitive to local water motion in the tissue, which is particularly sensitive to alterations in the renal interstitium, e.g. during renal fibrosis

Other Outcome Measures

1. Comparaison of T1 Value measured by T1 mapping MRI between medullary sponge kidney patients and controls. [Day 0]

   T1 mapping is a MRI sequence to estimate renal fibrosis

2. Comparaison of T2 Value measured by T2 mapping MRI between medullary sponge kidney patients and controls. [Day 0]

   T2 mapping is a MRI sequence to estimate renal alteration

3. In medullary sponge kidney patients, evaluation of the association between kidney function and : - ADC value measured by diffusion-weighted MRI - T1 Value measured by T1 mapping MRI - T2 Value measured by T2 mapping MRI [Day 0]

4. In medullary sponge kidney patients, evaluation of the association between 24 hours calciuria and : - ADC value measured by diffusion-weighted MRI - T1 Value measured by T1 mapping MRI - T2 Value measured by T2 mapping MRI [Day 0]

   exploration if medulla modifications can lead to hypercalciuria

5. In medullary sponge kidney patients, evaluation of the association between 24 hours citraturia and : - ADC value measured by diffusion-weighted MRI - T1 Value measured by T1 mapping MRI - T2 Value measured by T2 mapping MRI [Day 0]

   exploration if medulla modifications can lead to hypocitraturia

6. In medullary sponge kidney patients, evaluation of the association between urine pH and : - ADC value measured by diffusion-weighted MRI - T1 Value measured by T1 mapping MRI - T2 Value measured by T2 mapping MRI [Day 0]

   exploration if medulla modifications is correlated to urine pH modifications

7. In medullary sponge kidney patients, evaluation of the association between maximum urinary osmolarity and : - ADC value measured by diffusion-weighted MRI - T1 Value measured by T1 mapping MRI -T2 Value measured by T2 mapping MRI [Day 0]

   exploration if medulla modifications can lead to a decrease of renal concentration ability

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• medullary sponge kidney attending medical consultation

• Patients with glomerular filtration rate > 60 mL/min/1.73m2 without kidney stone

• consent signed

• effective contraceptive method for women

• affiliated to social insurance scheme

Exclusion Criteria:

• kidney transplant

• polycystic kidney diseases

• Chronic kidney disease (GFR < 60 mL/min/1,73m² )

• MRI contraindications (claustrophobia, pacemaker, cardioverter defibrillators implantable, mechanical heart valve non MRI-compatible)

• Weight> 130 kg

• pregnancy

• legal protection measure (guardianship, curatorship)

• Deprived of liberty by a judicial or administrative decision

• subject participating in another research including an exclusion period still in progress at inclusion

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hôpital Edouard Herriot	Lyon		France	69003

Sponsors and Collaborators

• Hospices Civils de Lyon

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Hospices Civils de Lyon
• ClinicalTrials.gov Identifier: NCT05682053
• Other Study ID Numbers: 69HCL22_0366; 2022-A01467-36
• First Posted: Jan 12, 2023
• Last Update Posted: Jan 12, 2023
• Last Verified: Dec 1, 2022

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Hospices Civils de Lyon: medullary sponge kidney; kidney stone; multiparametric MRI; medullary function
• Additional relevant MeSH terms: Medullary Sponge Kidney; Polycystic Kidney Diseases

Study Results

No Results Posted as of Jan 12, 2023