High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood

Sponsor

Gustave Roussy, Cancer Campus, Grand Paris (Other)

Overall Status

Unknown status

CT.gov ID

NCT00180791

Collaborator

(none)

Enrollment

Location

Study Details

Study Description

Brief Summary

The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.

Condition or Disease	Intervention/Treatment	Phase
Medulloblastoma Brain Tumors Neuroectodermal Tumors, Primitive	Drug: Etoposide, carboplatin, melphalan, cisplatin, thiotepa	Phase 2

Study Design

Study Type:

Interventional

Anticipated Enrollment :

71 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Treatment Protocol for High-Risk PNET Brain Tumors in Children With Surgery, Sequential Chemotherapy, Conventional and High-Dose With Peripheral Blood Stem Cell Transplantation and Radiation Therapy

Study Start Date :

Jul 1, 2002

Outcome Measures

Primary Outcome Measures

Response of medulloblastoma metastases to the chemotherapy regimen in children less than 5 years of age []
Progression-free survival of children less than 10 years of age with brain PNET []