The Impact of Dry Eye Syndrome on Metrics of Low Contrast Vision Before and After Meibomian Gland Expression
Study Details
Study Description
Brief Summary
The study aims to determine the impact of Meibomian Gland Dysfunction (MGD) dry eye on low contrast black/white (luminance) and cone color sensitivity performance and improvement in these functions after in-house non-invasive Meibomian gland (MG) expression.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This study offers possible benefits from gland expression to patients and subjects in terms of clinical measurements and care associated with meibomian gland dysfunction impacting all age ranges. Prior studies show that these interventions improve dry eye symptoms with intent to improve vision, low contrast color, and B/W vision after intervention in this study.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: non-invasive Meibomian gland (MG) expression Baseline testing of visual acuity, contrast sensitivity, color vision, and Innova, Inc. cone and B/W low contrast vision will be measured. The intervention will be standard clinical expression of Meibomian superior and inferior glands (MG) using a sterile cotton tip applicator to apply gentle pressure in a rolling motion in the direction of the MGs along the upper and lower eyelid margins to allow oil secretion of the tested eye. One drop of sterile saline will be instilled following the intervention to remove debris. The subject's visual acuity, contrast sensitivity, color vision, and Innova, Inc. cone and B/W low contrast vision will be measured before and after this intervention. |
Procedure: Meibomian gland (MG) expression
The procedure is performed with a sterile cotton tip applicator once in the upper and lower eyelids of the subject's choosing.
|
Outcome Measures
Primary Outcome Measures
- Change in Cone Contrast Sensitivity on the Cone Contrast Test (CCT, Innova Systems, Inc.) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures the lowest contrast (contrast sensitivity) to see red, green and blue cone specific letters.
- Change in Response Time on Cone Contrast Test (CCT, Innova Systems, Inc.) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures average response time in seconds to see red, green and blue low contrast letters.
Secondary Outcome Measures
- Change in Black White Contrast Sensitivity (Innova Systems, Inc) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures the lowest contrast (contrast sensitivity) to see black/white letters.
- Change in Response Time on Black White Contrast Sensitivity Test (Innova Systems, Inc) Response Time [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures average response time in seconds to see low contrast black/white letters
- Change in Visual Acuity Test at Low Contrast (Innova Systems, Inc) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures the smallest low contrast letters which can be seen.
- Change in Response Time on Visual Acuity Test at Low Contrast (Innova Systems, Inc) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures average response time in seconds to see low contrast visual acuity letters
- Change in Sensitivity on Cone Contrast Color Naming test (CCNT) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures the lowest contrast (contrast sensitivity) to see red, green, blue and grey letters.
- Change in Color Naming Accuracy on Cone Contrast Color Naming test (CCNT) [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
This computer test measures the accuracy of naming (number correct) low contrast red, green, blue and grey letters.
Other Outcome Measures
- Change in High Contrast Visual Acuity [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
The Precision Vision, Inc. Super Vision Chart will be used to measure visual acuity (smallest black letters on a white background that can be seen).
- Change in Small Letter Contrast Sensitivity [This test will occur prior to the intervention (Meibomian gland expression) and immediately after this intervention.]
The Precision Vision, Inc. Super Vision Chart will be used to measure the lowest contrast (contrast sensitivity) which can be seen using small (20/25) letters.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Individuals over the age of 18 years
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Healthy individuals with reported symptoms of dry eye such as burning, stinging, fluctuating vision, inappropriate tearing, and feelings of grittiness particularly with prolonged near work
Exclusion Criteria:
-
Under the age of 18
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Individuals currently using prescription eye medications for dry eye / MGD / inflammation / Infections or any other treatments.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of the Incarnate Word Rosenberg School of Optometry | San Antonio | Texas | United States | 78229 |
Sponsors and Collaborators
- University of the Incarnate Word
Investigators
- Study Chair: Jeffery Rabin, OD, PhD, University of the Incarnate Word
Study Documents (Full-Text)
None provided.More Information
Publications
- Gao Y, Liu R, Liu Y, Ma B, Yang T, Hu C, Qi H. Optical quality in patients with dry eye before and after treatment. Clin Exp Optom. 2021 Jan;104(1):101-106. doi: 10.1111/cxo.13111.
- Narayanan S, Miller WL, Prager TC, Jackson JA, Leach NE, McDermott AM, Christensen MT, Bergmanson JP. The diagnosis and characteristics of moderate dry eye in non-contact lens wearers. Eye Contact Lens. 2005 May;31(3):96-104. doi: 10.1097/01.icl.0000140907.45705.e2.
- Szczotka-Flynn LB, Maguire MG, Ying GS, Lin MC, Bunya VY, Dana R, Asbell PA; Dry Eye Assessment and Management (DREAM) Study Research Group. Impact of Dry Eye on Visual Acuity and Contrast Sensitivity: Dry Eye Assessment and Management Study. Optom Vis Sci. 2019 Jun;96(6):387-396. doi: 10.1097/OPX.0000000000001387.
- Thulasi P, Djalilian AR. Update in Current Diagnostics and Therapeutics of Dry Eye Disease. Ophthalmology. 2017 Nov;124(11S):S27-S33. doi: 10.1016/j.ophtha.2017.07.022.
- Yeh TN, Lin MC. Meibomian Gland Contrast Sensitivity and Specificity in the Diagnosis of Lipid-deficient Dry Eye: A Pilot Study. Optom Vis Sci. 2021 Feb 1;98(2):121-126. doi: 10.1097/OPX.0000000000001636.
- 2022-1283-EXP