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Melatonin and Adiponectin in Hypertensive Kidney Transplant

Sponsor
Sheba Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT00498576
Collaborator
(none)
60
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome. We have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients.

The aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. Secondly, to ask if there is any correlation between melatonin secretion and adiponectin levels.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    60 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Study Start Date :
    Sep 1, 2007

    Arms and Interventions

    Arm Intervention/Treatment
    1

    kidney transplant with hypertension
    2

    hypertensive patients with native kidneys
    3

    healthy controls

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 70 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • hypertension

      • kidney transplantation ( group 1)

      • good renal function

      Exclusion Criteria:

      • diabetes mellitus

      • cancer

      • renal failure

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Sheba Medical Center Ramat-gan Israel

      Sponsors and Collaborators

      • Sheba Medical Center

      Investigators

      • Principal Investigator: Avshalom Leibowitz, MD,

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00498576
      Other Study ID Numbers:
      • SHEBA-07-4730-AL-CTIL
      First Posted:
      Jul 10, 2007
      Last Update Posted:
      Jun 30, 2009
      Last Verified:
      Jun 1, 2009
      Keywords provided by , ,
      hypertension
      kidney transplant
      melatonin
      adiponectin
      Additional relevant MeSH terms:
      Hypertension

      Study Results

      No Results Posted as of Jun 30, 2009