Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients.
Study Details
Study Description
Brief Summary
Bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. This surgeries are major surgeries include risk of mortality still.
Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. Melatonin is neurohormone with the profile of a novel hypnotic-anesthetic agent.
The purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Bariatric surgical procedures are associated with low short-term mortality and may be associated with long-term reductions in all-cause, cardiovascular, and cancer-related mortality. This surgeries are major surgeries include risk of mortality still.
Melatonin is a hormone secreted from the pineal gland. Melatonin is an antioxidant, antinociceptive, hypnotic, anticonvulsant, neuroprotective, anxiolytic, sedative and analgesic. Irregularity of melatonin secretion causes a sleep irregularities, psychosis in intensive care unit and some behavioral disorder. The hypnotic, antinociceptive, and anticonvulsant properties of melatonin endow this neurohormone with the profile of a novel hypnotic-anesthetic agent.
The purpose of this study is to investigate the preoperative, perioperative and postoperative melatonin levels in bariatric surgery under general anesthesia and to investigate the relationship between melatonin level and analgesia requirement.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Melatonin and bariatric surgery the relationship between melatonin level and analgesia requirement. |
Diagnostic Test: melatonin
the relationship between melatonin level and analgesia requirement.
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Outcome Measures
Primary Outcome Measures
- Melatonin Level [Change from Baseline melatonin at postoperative 24 hours]
Melatonin is a hormone secreted from the pineal gland. It shows a daily biorhythm. Melatonin level can be measured in the blood and in urine collected for 24 hours.
Secondary Outcome Measures
- Morphine consumption [change from postoperative up to 24 hours]
Morphine is analgesic agent. It will used postoperative period
Eligibility Criteria
Criteria
Inclusion Criteria:
- American Society of Anesthesiologists (ASA) 3-4 status, aged between 18-65 years who are scheduled to undergo bariatric surgery.
Exclusion Criteria:
Patients with cardiovascular and pulmonary disease, those with ASA III-IV and propofol, fentanyl, remifentanil and rocuronium allergy.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Inonu university | Malatya | Turkey | 044100 |
Sponsors and Collaborators
- Inonu University
Investigators
- Study Director: Türkan Toğal, Prof., Inonu University Faculty of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
- Gögenur I, Ocak U, Altunpinar O, Middleton B, Skene DJ, Rosenberg J. Disturbances in melatonin, cortisol and core body temperature rhythms after major surgery. World J Surg. 2007 Feb;31(2):290-8.
- Hansen MV. Chronobiology, cognitive function and depressive symptoms in surgical patients. Dan Med J. 2014 Sep;61(9):B4914.
- Naguib M, Gottumukkala V, Goldstein PA. Melatonin and anesthesia: a clinical perspective. J Pineal Res. 2007 Jan;42(1):12-21. Review.
- MAE5