SleepDance: Toward a Real-time Access to Sleepers' Mental Content

Sponsor

Assistance Publique - Hôpitaux de Paris (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05452733

Collaborator

Institut National de la Santé Et de la Recherche Médicale, France (Other)

200

Enrollment

Location

Arms

Anticipated Duration (Months)

8.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Sleep is crucial for global cognitive functioning, but its exact functions and mechanisms are still poorly understood. Cognitive studies of sleep typically rely on linking electrophysiological changes measured during sleep with behavioral and neural changes collected in tasks performed during wakefulness. What concomitantly happens in the mind of sleeping subjects is often ignored, certainly because it is virtually inaccessible. Yet, major advances in the understanding of human behaviors have resulted from an integrated approach that combines both neural and cognitive measures of their ongoing mental processes. The goal of this study is to provide real-time measures of the cognitive processes occurring within sleep.

To prompt real-time access to the sleeping mind, investigators will use auditory stimulation in people with unique sleep peculiarities: sleepwalkers whose overt behaviours may enable to objectively visualize ongoing cognitive processes during non-REM (NREM) sleep.

Condition or Disease	Intervention/Treatment	Phase
Memory Reactivation Memory Consolidation Sleepwalking	Behavioral: differences of behavior between sleepwalking and non sleepwalking patient	N/A

Detailed Description

Investigators aim to offer a quantifiable, real-time measure of memory processing during NREM sleep by using memory-related cues to influence which behaviours sleepwalkers will exhibit. Because sleepwalking is characterized by complex behaviors emerging from NREM sleep, it could provide an observable window into mental activity in NREM sleep. While neuronal memory reactivations have largely been demonstrated in sleeping rodents, evidence for the existence of such reactivations in humans is at best indirect. Here, investigators will use targeted memory reactivation (TMR), a tool that allows to control which individual memories are reactivated on a trial by trial basis. TMR consists in associating sensory cues with a specific learning, then re-applying these cues during subsequent sleep to trigger the reactivation of the corresponding learning. Sleepwalkers will be trained on a modified version of the serial reaction time task: sleepwalkers will perform as fast and accurately as possible a sequence of gestures in response to auditory cues. Investigators goals are to: i) show that playing the auditory cues during NREM sleep triggers a behavioral replay of the learned 'choreography' in sleepwalkers, ii) quantify, with a gesture recognition algorithm, how the sleep gestures differ from the wake ones (speed, accuracy, sequence fidelity), and

test whether this evoked replay is accompanied by a congruent dream.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

200 participants

Allocation:

Non-Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Other

Official Title:

Toward a Real-time Access to Sleepers' Mental Content

Anticipated Study Start Date :

Oct 1, 2022

Anticipated Primary Completion Date :

Sep 30, 2024

Anticipated Study Completion Date :

Sep 30, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Sleepwalking patient	Behavioral: differences of behavior between sleepwalking and non sleepwalking patient movement registry done by camera when low intensity sound are send to patient during sleep.
Active Comparator: Non sleepwalking patient	Behavioral: differences of behavior between sleepwalking and non sleepwalking patient movement registry done by camera when low intensity sound are send to patient during sleep.

Arm

Intervention/Treatment

Experimental: Sleepwalking patient

Behavioral: differences of behavior between sleepwalking and non sleepwalking patient

movement registry done by camera when low intensity sound are send to patient during sleep.

Active Comparator: Non sleepwalking patient

Behavioral: differences of behavior between sleepwalking and non sleepwalking patient

movement registry done by camera when low intensity sound are send to patient during sleep.

Outcome Measures

Primary Outcome Measures

Behavioral reaction [2 days]
number of behavioral reactivations of the motor sequence following the auditory cues during sleep

Secondary Outcome Measures

Evaluation of targeted memory reactivation (TMR) success in sleepwalkers by movements test [2 days]
test whether performance is better for movements that have been cued during sleep (vs. uncued ones) in sleepwalkers
Quantification of movements exhibited during sleep [2 days]
The quantification of movement will be evaluated by combinaison of the reaction time, speed and precision of movements exhibited by sleepwalkers during sleep vs. wakefulness
Determination of the link between dream and sensory cues [2 days]
Comparison between the number of dreams related to the motor sequence on the 2nd night (after TMR) vs. during the 1st one.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 35 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Age between 18-35 y.o
Written consent
Affiliated to social security
Sleepwalking (group patients only)

Exclusion Criteria:

Psychiatric or neurologic disorder
Sleep disorder except sleepwalking for the patient group
Surdity
Pain or physical disability affecting the upper limbs
Consumption of drugs altering sleep structure
Subjects under legal protection

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Service des Pathologies du Sommeil, Hôpital Pitié-Salpétrière	Paris		France	75013

Sponsors and Collaborators

Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France

Investigators

Principal Investigator: Isabelle Arnulf, MD PhD, APHP
Study Director: Delphine Oudiette, PhD, Institut National de la Santé Et de la Recherche Médicale, France