OCS: Cavernous Sinus Dissection and Bleeding in Meningiomas
Study Details
Study Description
Brief Summary
The blood loss will be compared in middle fossa meningiomas which will receive pealing of the outer layer of the lateral wall of the cavernous sinus and those which will not revive pealing before the dura is opened
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 4 |
Detailed Description
Cases with middle fossa meningiomas will be randomised to one of two surgical techniques. The first technique will involve pealing of the outer layer of the lateral wall of the cavernous sinus before the dura is opened and the tumour attacked, and the second group of cases will be operated by a standard technique, where the tumour will be directly attacked with out pealing of the outer layer of the lateral wall of the cavernous sinus. Blood loss will be monitored in each case by calculating the amount of blood in the suction container and subtracting it from the amount of fluids used for irrigation during surgery. The number of cotton patties and dressings will be also counted with each case as well as the number of gauzes used. The pre-operative complete blood picture will be documented particularly the haemoglobin , hematocrits and others. The same lab data will be also monitored after surgery. The amount of blood transfusion required will also be calculated in each case.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Conventional surgery intra-dural This arm will be surgically operated by direct attack of the tumour after opening the dura |
Other: surgery
pealing of the outer layer of the cavernous sinus
|
| Experimental: Pealing surgery extra-dural This arm the pealing of the outer layer of the lateral wall of the cavernous sinus will be done before the dura is opened. After the pealing is completed, the middle meningeal artery will be divided at the foramen spinosum. Then, the dura will be opened and the tumour attacked. |
Other: surgery
pealing of the outer layer of the cavernous sinus
|
Outcome Measures
Primary Outcome Measures
- Amount of blood loss as estimated by cubic centimetres during surgery [three months]
Secondary Outcome Measures
- Radically of surgery as estimated by post-operative tumour volume in cubic centimetres on post-operative MRI [3 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Meningiomas of the middle cranial fossa
Exclusion Criteria:
- Meningiomas outside the middle cranial fossa
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Kasralainy medical college, Cairo University | Cairo | Greater Cairo | Egypt | 11553 |
Sponsors and Collaborators
- Kasr El Aini Hospital
Investigators
- Principal Investigator: Ahmed Hegazy, MD, Professor of neurosurgery, faculty of medicine, Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- N-44-2016