Study of Metabolic Content of Urine
Study Details
Study Description
Brief Summary
The purpose of this research study is to test the different components in urine and see if they can be matched to food, exercise and sleep that participants report. The researchers are trying to find out if urine would allow them to predict medical problems as they are happening. Participants are healthy volunteers who are willing to give urine samples on a daily basis, and can expect to be in the study for 28 days.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The purpose of this research study is to analyze urine samples using Mass Spectrometry to identify metabolites that have the potential to be used for medical diagnosis. This data, along with data from wearable devices, will be combined and analyzed to correlate what an individual does on a daily basis with how their body metabolizes their choices. This type of data may provide insights into the origins and progression of diseases in a short time span.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Sleep limited Participants will be asked to limit their sleep |
Other: Urine sample
Collection of 36-84 urine samples over a 14 consecutive day period.
Other: Sleep restriction
Participants will be asked to limit their sleep to 4 hours within a 24-hour period for 2 days in a row.
|
| Experimental: No sleep limitation Participants will be asked to get their normal amount of sleep. |
Other: Urine sample
Collection of 36-84 urine samples over a 14 consecutive day period.
|
Outcome Measures
Primary Outcome Measures
- Change in inflammation [Baseline to day 14]
Changes in inflammation will be measured by hs-CRP via short-term sleep restriction.
- Correlate biohealth data with concentrations of urine metabolites [Daily for 14 days]
To explore connections between urine metabolite concentrations and others measures of health and lifestyle, biometric data will be collected using a FitBit watch (sleep and exercise), nutritional data (food logs) and a questionnaire (tobacco use). Urine will be analyzed using mass spectrometry to isolate metabolites. The metabolites will then be cross-referenced against databases of known metabolites in order to identify them and their disease associations.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Must be 18 years or older
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Be able to provide informed consent
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Stated willingness to comply with all study procedures and have availability for the duration of the study
Exclusion Criteria:
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Presence of a condition(s) or diagnosis, either physical or psychological, that limits the ability to urinate in the collection apparatus
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Individuals who do not consistently get at least 6 hours of sleep per night
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Individuals who have a sleep disorder diagnosis.
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Individuals who live in the state of New York
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Wisconsin | Madison | Wisconsin | United States | 53705 |
Sponsors and Collaborators
- University of Wisconsin, Madison
- Morgridge Institute for Research
Investigators
- Principal Investigator: Joshua Coon, MD, University of Wisconsin, Madison
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2022-1111
- A537700
- SMPH/BIOMOLEC CHEM/BIOMOL CHM
- Protocol Version 9/28/22