Metabolic Responses to Bariatric Surgery
Study Details
Study Description
Brief Summary
Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Study participation by invitation after complete pre-surgical work up at UC Davis Health System. Patients will be invited to participate if they meet all inclusion criteria's after completing all necessary clinical visits including lab studies, counseling, and participation in educational programs. During the pre-operative visit patients interested in participation will complete all necessary consent documentation. Pre-operative labs (blood and urine) will be collected along with additional blood, urine, and fecal samples will be collected pre-operatively. During surgery (Roux-en-Y Gastric Bypass surgeries only) tissue collection will include subcutaneous & omental fat, jejunum, and liver biopsy. Post surgery patient will be observed for weight loss and resolution of co-morbidities. At designated times post surgery when lab studies are ordered additional blood/urine samples will be collected and analyzed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Weight Loss Surgery - Healthy Patients consented to participate have met the NIH criteria for Bariatric Surgery and have completed the normal pre-operative work up including nutritional counseling, psychological evaluation, and all necessary studies to rule out other co-morbid conditions prior to surgery. Patients do not have metabolic syndrome. |
Other: Surgery
Patients wishing to participate in the research will complete all necessary pre-operative work-up labs, testing & counseling, complete and sign the informed consent. During weight loss surgery a small amount of subcutaneous and omental fat will be collected for analysis, with subsequent blood collection post surgery for analysis.
|
| Weight Loss Surgery - Metabolic Syndrome Patients consented to participate have met the NIH criteria for Bariatric Surgery and have completed the normal pre-operative work up including nutritional counseling, psychological evaluation, and all necessary studies to rule out other co-morbid conditions prior to surgery. Patients have metabolic syndrome. |
Other: Surgery
Patients wishing to participate in the research will complete all necessary pre-operative work-up labs, testing & counseling, complete and sign the informed consent. During weight loss surgery a small amount of subcutaneous and omental fat will be collected for analysis, with subsequent blood collection post surgery for analysis.
|
Outcome Measures
Primary Outcome Measures
- Tensile Strength of White Adipose Tissue [July 2012]
During the research tissue samples were compared between healthy obese patients (no diabetes, controlled HTN, no dyslipidemia) with tissue samples collected on non-healthy obese patients (type II diabetes) and using fat collected from mice as a control.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Meet NIH Criteria for Bariatric Surgery
-
Between the Age of 18-55
-
Dyslipidemia controlled with medication
-
Impaired glucose metabolism or type 2 diabetes
Exclusion Criteria:
- Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of California Davis Medical Center | Sacramento | California | United States | 95817 |
Sponsors and Collaborators
- University of California, Davis
Investigators
- Principal Investigator: Mohamed R Ali, MD, University of California Davis Health System
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- 228969