Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI

Sponsor

Brock University (Other)

Overall Status

Completed

CT.gov ID

NCT03808363

Collaborator

(none)

Enrollment

Location

Arm

10.4

Actual Duration (Months)

0.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.

Condition or Disease	Intervention/Treatment	Phase
Metabolic Syndrome Cardiovascular Diseases	Other: High Intensity Interval Training	N/A

Detailed Description

This study aims to challenge the effectiveness of the current aerobic exercise recommendations for individuals with spinal cord injuries (SCI). Currently, moderate intensity continuous training (MICT) is suggested however this study intends to explore the effectiveness of high intensity interval training (HIIT). To do so, approximately 8 individuals with SCI will be undergo a 6 week HIIT intervention consisting of 3 sessions per week. With a focus on cardiometabolic health markers (listed in outcome measure section), we aim to provide support for HIIT as a viable method of mitigating cardiovascular risk in a SCI population.

Study Design

Study Type:

Interventional

Actual Enrollment :

8 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Intervention Model Description:

6 week exercise intervention testing the efficacy of high intensity interval training as compared to current research supporting moderate intensity continuous exercise as a means to mitigate cardiometabolic decline following spinal cord injury6 week exercise intervention testing the efficacy of high intensity interval training as compared to current research supporting moderate intensity continuous exercise as a means to mitigate cardiometabolic decline following spinal cord injury

Masking:

None (Open Label)

Primary Purpose:

Prevention

Official Title:

High-intensity Interval Training Versus Moderate Intensity Continuous Training as a Means to Improve Cardiometabolic Health After Spinal Cord Injury

Actual Study Start Date :

Feb 1, 2019

Actual Primary Completion Date :

May 30, 2019

Actual Study Completion Date :

Dec 15, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: High Intensity Interval Training Group Approximately eight individuals with spinal cord injuries will participate in high intensity interval training for 6 weeks	Other: High Intensity Interval Training Participants assigned to this group will perform a very mild 5-minute warm-up (0 resistance, and 60 rpm), followed by 5 one-minute bouts of high intensity exercise, with 90 seconds between each bout. These bouts will be followed by a 3-minute cool down (0 resistance, and 60 rpm). The high-intensity exercise will be performed at an intensity of 17 on the Borg rating of perceived exertion (RPE) scale (very hard), and the 90 second active rest intervals will be performed at an intensity of 7-9 (very, very light - very light). The exercise will be performed on the NuStep machine 3 times a week for 6 weeks. Other Names: HIIT

Arm

Intervention/Treatment

Experimental: High Intensity Interval Training Group

Approximately eight individuals with spinal cord injuries will participate in high intensity interval training for 6 weeks

Other: High Intensity Interval Training

Participants assigned to this group will perform a very mild 5-minute warm-up (0 resistance, and 60 rpm), followed by 5 one-minute bouts of high intensity exercise, with 90 seconds between each bout. These bouts will be followed by a 3-minute cool down (0 resistance, and 60 rpm). The high-intensity exercise will be performed at an intensity of 17 on the Borg rating of perceived exertion (RPE) scale (very hard), and the 90 second active rest intervals will be performed at an intensity of 7-9 (very, very light - very light). The exercise will be performed on the NuStep machine 3 times a week for 6 weeks.

Other Names:

HIIT

Outcome Measures

Primary Outcome Measures

Waist circumference (inches) [6 weeks]
Central adiposity will be measured by tape measure to monitor possible weight loss
Cholesterol [6 weeks]
Total and HDL cholesterol will be measured in serum
Triglycerides [6 weeks]
Triglycerides will be measured in serum
Glycated Hemoglobin (HbA1c) [6 weeks]
Glycated hemoglobin will be measured in whole blood as an indicator of diabetic risk
Tumor necrosis factor (TNF-a) [6 weeks]
TNF-a will be used as an inflammatory representative and will be measured in serum
Interleukin - 10 (IL-10) [6 weeks]
IL-10 will will be used as an anti-inflammatory representative and will be measured in serum
Pulse Wave Velocity [6 weeks]
Arterial stiffness, a common measure for cardiac risk will be measured
Blood pressure [6 weeks]
Measured through a digital cuff, the focus will be on both systolic and diastolic
Peak Oxygen Consumption (VO2 peak) [6 weeks]
VO2 peak will be measured by a Moxus metabolic cart to determine changes in fitness
C Reactive Protein (CRP) [6 weeks]
CRP will will be used as an inflammatory representative and will be measured in serum
Leptin [6 weeks]
Leptin will will be used as a body fat representative and will be measured in serum
Adiponectin [6 weeks]
Adiponectin will will be used as a surrogate for insulin resistance and will be measured in serum

Secondary Outcome Measures

Physical Activity Enjoyment Scale (PACES) [6 weeks]
All participants will complete the physical activity enjoyment scale (PACES) to indicate enjoyment of HIIT. With a total of 18 questions, options 1 through 7 going from a positive to a negative overall experience with the HIIT protocol will be documented.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Individuals with a spinal cord injury (paraplegia or tetraplegia, complete or incomplete) who are at least one-year post injury.
Declared medically stable, and able to communicate clearly in English.