Calorie Restricted Diet and Exercise
Study Details
Study Description
Brief Summary
Calorie-restricted(CR) diet and exercise were effective to reduce Metabolic syndrome(MetS), however, its effect on knee functions for MetS patients with degenerate meniscus tears(DMTs) was still poorly investigated.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The CR diet and exercise group received a balanced diet with an energy consists carbohydrates 45-65%; fat 20-35%; and protein 10- 35% and a deficit of 600 kcal/day from their daily energy requirement [23]. The energy intake per day of the calorie restricted diet was calculated based on the detailed composition of meals such as rice, vegetables, eggs, pork, and beef, using the Chinese food composition tables[24]. Our diets were cooked with traditional Chinese cooking methods such as boiling, stir-frying, and stewing. During the intervention, other lipid-lowering drugs were not allowed to intake supplement as it alters the outcome. Participants were guided by a dietitian for modulations of their caloric intake weekly for six months.
The exercise intervention consists of aerobic exercises and resistance exercise, flexibility exercises about 150 minutes for≥2 d•wk for six months. The aerobic exercises included walking on a treadmill, stationary cycling for at least 30 minutes for≥2 d•wk, while, resistance exercises included nine upper-extremity and lower-extremity exercise with weighting lift machines for ≥2 d•wk, while, flexibility exercise including the major muscle-tendon groups (a total of 60 s per exercise) for ≥2 d•wk. Participants performed 1 or 2 sets with 8-12 repetitions of each exercise. The exercise sessions were monitored by telephone video. Calorie restricted diet and exercise group contain both the above intervention for 6 months.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Calorie restricted diet and excecise intervention The CR diet and exercise group received a balanced diet with an energy consists carbohydrates 45-65%; fat 20-35%; and protein 10- 35% and a deficit of 600 kcal/day from their daily energy requirement [23]. Participants were guided by a dietitian for modulations of their caloric intake weekly for six months. The exercise intervention consists of aerobic exercises and resistance exercise, flexibility exercises about 150 minutes for≥2 d•wk for six months. Calorie restricted diet and exercise group contain both the above intervention for 6 months. |
Behavioral: calorie restricted diet and exercise
The CR diet and exercise group received a balanced diet with an energy consists carbohydrates 45-65%; fat 20-35%; and protein 10- 35% and a deficit of 600 kcal/day from their daily energy requirement.The exercise intervention consists of aerobic exercises and resistance exercise, flexibility exercises about 150 minutes for≥2 d•wk for six months. The aerobic exercises included walking on a treadmill, stationary cycling for at least 30 minutes for≥2 d•wk, while, resistance exercises included nine upper-extremity and lower-extremity exercise with weighting lift machines for ≥2 d•wk, while, flexibility exercise including the major muscle-tendon groups (a total of 60 s per exercise) for ≥2 d•wk. Participants performed 1 or 2 sets with 8-12 repetitions of each exercise. The exercise sessions were monitored by telephone video.
|
| Active Comparator: exercise group participants then underwent libitum diet and the same exercise intervention during the program |
Behavioral: calorie restricted diet and exercise
The CR diet and exercise group received a balanced diet with an energy consists carbohydrates 45-65%; fat 20-35%; and protein 10- 35% and a deficit of 600 kcal/day from their daily energy requirement.The exercise intervention consists of aerobic exercises and resistance exercise, flexibility exercises about 150 minutes for≥2 d•wk for six months. The aerobic exercises included walking on a treadmill, stationary cycling for at least 30 minutes for≥2 d•wk, while, resistance exercises included nine upper-extremity and lower-extremity exercise with weighting lift machines for ≥2 d•wk, while, flexibility exercise including the major muscle-tendon groups (a total of 60 s per exercise) for ≥2 d•wk. Participants performed 1 or 2 sets with 8-12 repetitions of each exercise. The exercise sessions were monitored by telephone video.
|
Outcome Measures
Primary Outcome Measures
- KOOS [up to 12 months]
the questionnaires of the Knee injury and Osteoarthritis Outcome Score (KOOS) subscales
- IKDC [up to 12 months]
the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC) score
Secondary Outcome Measures
- subscales of the KOOS pain [up to 12 month]
Secondary outcomes include five subscales of the KOOS covered pain, symptoms, activity of daily living, sport and recreational function, and knee related quality of life
- KOOS symptoms [up to 12 month]
Secondary outcomes include five subscales of the KOOS covered pain, symptoms, activity of daily living, sport and recreational function, and knee related quality of life
- KOOS activity of daily living [up to 12 month]
Secondary outcomes include five subscales of the KOOS covered pain, symptoms, activity of daily living, sport and recreational function, and knee related quality of life
- sport and recreational function [up to 12 month]
Secondary outcomes include five subscales of the KOOS covered pain, symptoms, activity of daily living, sport and recreational function, and knee related quality of life
- knee related quality of life [up to 12 month]
Secondary outcomes include five subscales of the KOOS covered pain, symptoms, activity of daily living, sport and recreational function, and knee related quality of life
- SBP [up to 12 month]
systolic blood pressure
- DBP [up to 12 month]
diastolic blood pressure
- BMI [up to 12 month]
body mass index
- weight [up to 12 month]
weight
- HDL [up to 12 month]
high-density lipoprotein cholesterol
- LDL-C [up to 12 month]
low-density lipoprotein cholesterol
- TG [up to 12 month]
triglycerides
- TC [up to 12 month]
total cholesterol
- FBG [up to 12 month]
fast blood glucose
- WC [up to 12 month]
waist circumstance
Eligibility Criteria
Criteria
Inclusion Criteria:
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• Must be age between 35 and 70 years old;
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Clinical diagnosis of metabolic syndrome;
Exclusion Criteria:
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• Must be able to have no acute knee injury such as car crash or acute sports injury;
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Must be able to have no knee surgeries history;
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Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity;
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Must be able to have no contraindications to MRI;
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Must be able to have no severe cardiopulmonary disease;
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Must be able to have no musculoskeletal or neuromuscular impairments ;
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Must be able to have good visual, hearing, or cognitive;
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | First Affiliated Hospital of Jinzhou Medical University | Jinzhou | Liaoning | China | 121000 |
Sponsors and Collaborators
- The First People's Hospital of Jingzhou
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- exercise01