Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

• Sponsor: German Institute of Human Nutrition (Other)
• Overall Status: Completed
• CT.gov ID: NCT00774488
• Collaborator: German Research Foundation (Other)
• Enrollment: 17
• Duration (Months): 17.9

Study Details

Study Description

Brief Summary

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Condition or Disease	Intervention/Treatment	Phase
Metabolic Syndrome; Obesity; Insulin Sensitivity	Other: Glucose dependent insulinotropic polypeptide (GIP)	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 17 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Single (Participant)
• Primary Purpose: Basic Science
• Study Start Date: Jan 1, 2006
• Actual Primary Completion Date: Jul 1, 2007
• Actual Study Completion Date: Jul 1, 2007

Outcome Measures

Primary Outcome Measures

1. Changes in gene expression of subcutaneous adipose tissue with microarray analysis [3 years]

Secondary Outcome Measures

1. Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc. [3 years]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 70 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• BMI > 28

• Healthy subjects

• Normal glucose tolerance

Exclusion Criteria:

• Diabetes,IFG, IGT

• Chronical-inflammatory diseases

• Hb < 12g/dl

• Elevation in liver enzymes or creatinin concentrations

• Great weight changes within last 12 months

• Any cancer diagnosis in last 10 years

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• German Institute of Human Nutrition
• German Research Foundation

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00774488
• Other Study ID Numbers: GIP-Genexpression Study
• First Posted: Oct 17, 2008
• Last Update Posted: Oct 17, 2008
• Last Verified: Oct 1, 2008

• Keywords provided by , ,: Euglycemic-hyperinsulinemic clamp; fat biopsies; microarray analysis; quantitative real time PCR; overnutrition; low grade-inflammation
• Additional relevant MeSH terms: Metabolic Syndrome; Insulin Resistance; Gastric Inhibitory Polypeptide

Study Results

No Results Posted as of Oct 17, 2008