The Effect of Bariatric/Metabolic Surgery on GFR
Study Details
Study Description
Brief Summary
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity. The study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Metabolic syndrome is strongly associated with obesity and the patients with this syndrome are at increased risk for cardiovascular disease. Obesity constitutes a strong risk factor for the development of chronic kidney disease. Among diabetics, obesity is known to amplify the risk for kidney disease. Bariatric surgery has yielded dramatic results including longitudinal loss of excess body weight and either complete reversal or significant improvement of several features of metabolic syndrome. In addition, many observational studies have demonstrated significant reduction in proteinuria after bariatric surgery.
However, the changes in the component of cardiovascular problem among metabolic syndrome and changes in renal filtration function or progression to end stage kidney disease in morbidly obese patients after weight loss surgery have not been extensively studied. Therefore, our study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Obese patients 15 Obese patients (BMI>30) having one of comorbidity (type 2 diabetes, dyslipidemia, or hypertension) and morbid obese patients (BMI>35) accepted for bariatric surgery. |
Procedure: Bariatric surgery
Laparoscopic or Robot R-Y gastric bypass
|
| No Intervention: Control patients 15 matched controls receiving Intensive medical therapy |
Outcome Measures
Primary Outcome Measures
- Change in Glomerular filtration rate [before, 6, 12month after surgery]
Secondary Outcome Measures
- Change in excessive body weight [before, 6, 12month after surgery]
- Systolic function (EF) [Before, 6 and 12month after surgery]
measured by echocardogram
- Diastolic function (E,A,DT,IVRT,E/e') [Before, 6 and 12month after surgery]
measured by echocardogram
- Change of daytime blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure) [Before, 6, and 12month after surgery]
measured by 24 hours ambulatory blood pressure monitoring
- Change of night time blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure) [Before, 6, and 12month after surgery]
measured by 24 hours ambulatory blood pressure monitoring
- Change of 24 hours blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure) [Before, 6, and 12month after surgery]
measured by 24 hours ambulatory blood pressure monitoring
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Morbid obesity (BMI>30) patients with one of comorbidity (type 2 diabetes, dyslipidemia, or hypertension)
-
Morbid obese patients (BMI>35)
Exclusion Criteria:
-
Prior bariatric surgery
-
Malignancy (any type)
-
End stage renal disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hanyang University Hospital | Seoul | Korea, Republic of | 133-792 |
Sponsors and Collaborators
- Hanyang University
Investigators
- Principal Investigator: Tae Kyung Ha, MD, PhD, Hanyang University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NCT02271568