The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

Sponsor

University of Texas at Austin (Other)

Overall Status

Completed

CT.gov ID

NCT03856606

Collaborator

(none)

Enrollment

Location

Arms

4.5

Actual Duration (Months)

1.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

Condition or Disease	Intervention/Treatment	Phase
Metabolic Syndrome X Atherosclerosis Insulin Resistance Hyperinsulinism Glucose Metabolism Disorders Metabolic Disease Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Cardiovascular Diseases	Behavioral: Prolonged sitting without exercise Behavioral: Prolonged sitting with interval exercise	N/A

Detailed Description

All subjects complete two trials in a randomized crossover design, with each trial occurring over 4 days with a minimum of seven days between trials. The first two days of each trial serve as a control period allowing for familiarization and the control of physical activity and calorie consumption prior to the intervention. Following each control period, subjects then perform one of the interventions on Day 3. The interventions consist of either eight-hours of prolonged sitting, or eight hours of sitting interrupted every hour by five sprints lasting 4 seconds each using the interval exercise. On day 4, all subjects will undergo a high fat glucose tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Study Design

Study Type:

Interventional

Actual Enrollment :

8 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

None (Open Label)

Primary Purpose:

Prevention

Official Title:

The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

Actual Study Start Date :

Feb 20, 2018

Actual Primary Completion Date :

Jul 8, 2018

Actual Study Completion Date :

Jul 8, 2018

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Prolonged sitting without exercise Subjects will be asked to undergo prolonged sitting (~14 hours) of 1 day and will not be asked to perform interval exercise.	Behavioral: Prolonged sitting without exercise Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
Experimental: Prolonged sitting with interval exercise Subjects will be asked to undergo prolonged sitting (~14 hours) of 1 day and will be asked to perform interval exercise every hour on the hour.	Behavioral: Prolonged sitting with interval exercise Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo a prolonged sit which with will be broken up every hour on the hour by a small bout of interval exercise. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Arm

Intervention/Treatment

Experimental: Prolonged sitting without exercise

Subjects will be asked to undergo prolonged sitting (~14 hours) of 1 day and will not be asked to perform interval exercise.

Behavioral: Prolonged sitting without exercise

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Experimental: Prolonged sitting with interval exercise

Subjects will be asked to undergo prolonged sitting (~14 hours) of 1 day and will be asked to perform interval exercise every hour on the hour.

Behavioral: Prolonged sitting with interval exercise

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo a prolonged sit which with will be broken up every hour on the hour by a small bout of interval exercise. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Outcome Measures

Primary Outcome Measures

Plasma Triglycerides [6-hours]
Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

Secondary Outcome Measures

Plasma Insulin [6-hours]
Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
Plasma Glucose [6-hours]
Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Exclusion Criteria:

cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
respiratory problems
musculoskeletal problems that prevent prolonged sitting or exercise
susceptibility to fainting
Pregnancy