High-Intensity Interval Training on Pre-Hypertensive Subjects
Study Details
Study Description
Brief Summary
Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Despite exercise training decrease blood pressure in 'average' terms, there is a wide interindividual variability after exercise training, being yet unknown what mode of exercise (e.g. endurance, strength, concurrent, or high intensity interval training) produce more/less non-responder (NR) prevalence (i.e., percentage of subjects who experienced a non-change/worsened response after training in some outcome).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: High Intensity Interval Training Cycling on cycle ergometers (OXFORDTM, model BE2601, OXOFORD Inc, Santiago, Chile) for 1 min at a subjective intensity of 8-10 points of the modified Borg scale of 1-10 points, and interspersed by inactive (without movement over the bicycle) of 2 minutes as recovery period. |
Behavioral: High Intensity Interval Training
High Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.
|
| Active Comparator: Control group Pre-hypertensive group was compared with healthy groups in the 2 manin variables systolic/diastolic blood pressure, as well as in other co-variables in pre-post changes. Thus, after the training intervention, and following the R and NR classification, we will compare the NR prevalence between both Pre-hypertensive and Healthy group. |
Behavioral: Control group
Moderade Intensity Interval Training pre-hypertensive group; Exercise will be performed at three sessions per week. All sessions will be supervised by an exercise physiologist during 16 weeks.
|
Outcome Measures
Primary Outcome Measures
- Change from Baseline in systolic blood pressure and diastolic blood pressure [Baseline and 16 weeks immediately after the interventions ends]
After this, we calculated the delta changes in both variables and classified to all subjects in responders (R) and non-responders (NR) to decrease systolic or diastolic blood pressure.
Secondary Outcome Measures
- Change from Baseline in body mass [Baseline and 16 weeks immediately after the interventions ends]
- Change from Baseline in body mass index [Baseline and 16 weeks immediately after the interventions ends]
BMI will be calculated as the body weight in kilograms divided by the square of the height in meters.
- Change from Baseline in waist circumference [Baseline and 16 weeks immediately after the interventions ends]
- Change from Baseline in fat mass [Baseline and 16 weeks immediately after the interventions ends]
- Change from Baseline in heart rate at rest [Baseline and 16 weeks immediately after the interventions ends]
Baseline and 16 weeks immediately after the interventions ends
- Change from Baseline in fasting glucose [Baseline and 16 weeks immediately after the interventions ends]
- Change from Baseline in lipids [Baseline and 16 weeks immediately after the interventions ends]
Lipid profile (low-density cholesterol, total cholesterol, high-density cholesterol and triglycerides)
- Change from Baseline in one maximum repetition strength test of leg-extension exercise [Baseline and 16 weeks immediately after the interventions ends]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Written informed consent;
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Interested in improving health and fitness;
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Systolic blood pressure > 120 mmHg and < 140 mmHg, and/or DBP ≥ 80 and < 90 mmHg according with standard classification;
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No drug therapy during the previous 3 months;
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Body mass index (BMI) 25 and 35 kg/m2); (c) physically inactive (according to the International Physical Activity Questionnaire previously validated in Chilean population)
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Normal /mild altered lipid profile (total cholesterol [TC] ~200 and ≤250 mg/dL, low-density lipids [LDL-C] ~140 mg/dL and ≤200 mg/dL, high-density lipids [HDL-C] ≥20 and ~40 mg/dL, triglycerides ~150 and ≤250 mg/dL) according with standard classification.
Exclusion Criteria:
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Cardiovascular contraindications to exercise histories of stroke;
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Asthma and chronic obstructive pulmonary disease;
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Musculoskeletal disorder such as low back pain;
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Smokers in the last 3 months were not included in the study.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cristian Alvarez | Osorno | Chile |
Sponsors and Collaborators
- Universidad Santo Tomas
- Healthcare Center Tomas Rojas
- University of Los Ríos
- Universidad Pública de Navarra
- Universidad del Rosario
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Number 03052015