Sugar Sweetened Beverages (SSB)- Effects on Metabolism

Sponsor

University of Zurich (Other)

Overall Status

Completed

CT.gov ID

NCT01733563

Collaborator

SNF Swiss National Foundation (Other), University of Lausanne (Other)

Enrollment

Location

Arms

Duration (Months)

2.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The objective of this study is to investigate the impact of sugar sweetened beverages on the fat metabolism of healthy young men. It is well known that consumption of beverages sweetened with fructose is associated with different health risks such as type 2 diabetes. The present study has been designed to dissect differences in the metabolic pathways of fructose and glucose, but also metabolic adaptations during fructose, glucose and sucrose diets. During a period of seven weeks subjects will consume either fructose, glucose or sucrose sweetened beverages or continue their usual drinking habits. During these seven weeks there will be different metabolic investigations using stable isotope tracers. First, the rate of lipolysis and beta-oxidation will be determined. Second, the rates of fatty acid synthesis will be measured. During all examinations there will also be substrate- and energy-utilization measurements by indirect calorimetry, blood analysis and morphometric measurements. Based on the literature main hypotheses are: Fructose enhances de novo lipogenesis postprandially and also in the fasting state significantly more than glucose by enhanced expression of lipogenic enzymes. Fructose decreases beta oxidation via downregulation of oxidative enzymes.

Condition or Disease	Intervention/Treatment	Phase
Metabolism	Procedure: Soft drink consumption	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

96 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Primary Purpose:

Prevention

Official Title:

Effects of Carbohydrate Containing Diets on Lipid Metabolism & Fatty Acid Oxidation in Healthy Young Men - a Randomized, Double-Blinded Study.

Study Start Date :

Apr 1, 2013

Actual Primary Completion Date :

May 1, 2016

Actual Study Completion Date :

May 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Experimental: fructose sweetened beverage Soft drink consumption: Subjects have to drink a fructose sweetened beverage (3x 200ml per day, 13.3g fructose/100ml) during 7 weeks	Procedure: Soft drink consumption
Experimental: glucose sweetened beverage Soft drink consumption: Subjects have to drink a glucose sweetened beverage (3x 200ml per day, 13.3g glucose/100ml) during 7 weeks	Procedure: Soft drink consumption
Experimental: sucrose sweetened beverage Soft drink consumption: Subjects have to drink a sucrose sweetened beverage (3x 200ml per day, 13.3g sucrose/100ml) during 7 weeks	Procedure: Soft drink consumption
Experimental: No change of eating habits No Soft drink consumption (no soft drink diet): Subjects do not change their eating habits during 7 weeks	Procedure: Soft drink consumption

Outcome Measures

Primary Outcome Measures

Lipogenesis [After total 6 weeks dietary intervention]
Measurement of lipogenesis is based on i. v. administration of stable isotope labelled acetate (1,2-13C-acetate). 13C incorporation into palmitate is quantified by mass-spectrometry. 13C incorporation correlates to the rate of fatty acid synthesis.

Secondary Outcome Measures

Lipolysis [After total 6 weeks dietary intervention]
Measurements using stable isotopes

Other Outcome Measures

Waist/Hip Ratio [After total 6 weeks dietary intervention]
Measurement waist/hip ratio using a nonstretchable band

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Inclusion criteria:

Healthy male volunteers aged 18-30
BMI between 19-24 kg/m2
Non-smoker

Exclusion criteria:

Acute or chronic infections, malignant disease, renal, hepatic (more than two-fold increased transaminases), pulmonary, neurological (epilepsy) or psychiatric diseases, manifested atherosclerosis, or any other disease precluding participation in the study.
Diabetes
Known alcohol, substance or drug abuse, concomitant medication
More than three hours of physical exercise per week
Consumption of more than 2 times 3 dl SSB daily
Subjects likely to fail to comply with the study protocol
Subjects who do not give informed consent

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University Hospital Zurich, Endocrinology and Diabetology	Zurich	ZH	Switzerland	8091

Sponsors and Collaborators

University of Zurich
SNF Swiss National Foundation
University of Lausanne

Investigators

Principal Investigator: Philipp Gerber, MD, University Hospital Zurich, Endocrinology and Diabetology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University of Zurich

ClinicalTrials.gov Identifier:

NCT01733563

Other Study ID Numbers:

SSB-Effects on metabolism

First Posted:

Nov 27, 2012

Last Update Posted:

May 12, 2016

Last Verified:

May 1, 2016

Keywords provided by University of Zurich

sugar sweetened beverages

fructose

lipogenesis

beta-oxidation

Study Results

No Results Posted as of May 12, 2016