Talc in Treating Patients With Malignant Pleural Effusion
Sponsor
Alliance for Clinical Trials in Oncology (Other)
Overall Status
Completed
CT.gov ID
NCT00002622
Collaborator
National Cancer Institute (NCI) (NIH), Eastern Cooperative Oncology Group (Other), Radiation Therapy Oncology Group (Other), North Central Cancer Treatment Group (Other)
501
241
2
133
2.1
0
Study Details
Study Description
Brief Summary
RATIONALE: Talc may relieve malignant pleural effusion. It is not yet known whether wet talc is more effective than dry talc in treating patients with malignant pleural effusion.
PURPOSE: Randomized phase III trial to compare the effectiveness of wet talc with dry talc in treating patients with malignant pleural effusion.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Detailed Description
OBJECTIVES: I. Compare the proportion of patients with successful pleurodesis at 30 days following treatment for malignant pleural effusion (MPE) by talc slurry via chest tube vs thoracoscopic talc insufflation. II. Compare the cost and cost effectiveness of both treatments for MPE. III. Compare the time to recurrence of effusion, duration of chest tube drainage after sclerosis, extent of postinstillation complications and toxicities, and the ability to re-expand the lung in patients randomized to these 2 treatments. IV. Evaluate the quality of life and pain experienced by patients during both treatments.
OUTLINE: This is a randomized study. Patients are stratified according to participating institution. Patients are randomized to one of two treatment arms. Arm I: Patients undergo pleurodesis. A chest tube is inserted, the pleural fluid is drained for 24 hours, and the lung is re-expanded to at least 90% of full expansion. Within 24-36 hours patients undergo sclerosis with talc slurry injected into the chest tube, which is then clamped. Patients are rotated in all possible directions, holding each position for about 30 minutes. After 2 hours the chest tube is unclamped and reattached to suction drainage, which is strictly measured for 24-hour totals. Following a decrease in drainage to no more than 150 ml/24 hours (usually by the second or third day postsclerosis), the chest tube is removed. Arm II: Patients receive thoracoscopic insufflation. The chest is explored thoracoscopically via single or multiple incisions using direct or videothoracoscopic visualization, and the lung is re-expanded to 90% of full expansion. Dry talc is pneumatically insufflated into the chest, with complete dispersion throughout the hemithorax. Following insufflation, the chest is drained via a chest tube, which is removed when the drainage is no more than 150 ml/24 hours (usually by day 2 or 3 following insufflation). Patients are removed from study for disease progression or an unsuccessful lung re-expansion. Patients are followed monthly for 6 months for relapse and survival.
PROJECTED ACCRUAL: Approximately 500 patients will be accrued for this study over 28 months.
Study Design
Study Type:
Interventional
Actual Enrollment
:
501 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Supportive Care
Official Title:
Sclerosis of Pleural Effusions by Talc Thoracoscopy Versus Talc Slurry: A Phase III Study
Study Start Date
:
Dec 1, 1994
Actual Primary Completion Date
:
Mar 1, 2005
Actual Study Completion Date
:
Jan 1, 2006
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Talc slurry via chest tube talc slurry via chest tube |
Drug: talc
4 to 5 grams talc in 100 cc saline via chest tube at bedside, one time
|
| Active Comparator: Talc via insufflation 4 to 5 grams talc via insufflation through direct or videoscopic thoracoscopy, one time |
Drug: Talc
4 to 5 grams talc via insufflation through direct or video thoracoscopy, one time
|
Outcome Measures
Primary Outcome Measures
- Successful pleurodesis [30 days]
- Cost and cost effectiveness [30 days]
cost and cost effectiveness of treating malignant pleural effusions
Secondary Outcome Measures
- Time to recurrence of effusion [6 months]
- Complications and toxicity [6 months]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 120 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS: Unilateral malignant pleural effusion requiring sclerosis (as judged by the attending surgeon) At least 3 months since treatment of contralateral effusion No chylous effusion
PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
More than 2 months Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Other: Able to undergo thoracoscopy under general or local anesthesia (as determined by the attending surgeon) Not pregnant Tests and observations must be completed within 1 week prior to randomization (chest x-ray within 1 week prior to procedure)
PRIOR CONCURRENT THERAPY: No prior intrapleural therapy No systemic therapy within 2 weeks prior to randomization or 2 weeks post pleurodesis Biologic therapy: Not specified Chemotherapy: No new systemic chemotherapy for 2 weeks prior to and at least 2 weeks after pleurodesis Endocrine therapy: No new hormonal therapy for 2 weeks prior to and at least 2 weeks after pleurodesis No concurrent steroids used as antiemetics Radiotherapy: Prior radiotherapy allowed No radiotherapy to entire hemithorax Palliative irradiation of symptomatic bone lesions allowed on the affected side if field does not include a significant portion of pleura Surgery: See Disease Characteristics
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Veterans Affairs Medical Center - Birmingham | Birmingham | Alabama | United States | 35233 |
| 2 | University of Alabama Comprehensive Cancer Center | Birmingham | Alabama | United States | 35294 |
| 3 | Huntsville Hospital System | Huntsville | Alabama | United States | 35801 |
| 4 | Urology Associates - Mobile AL | Mobile | Alabama | United States | 36640 |
| 5 | MBCCOP - University of South Alabama | Mobile | Alabama | United States | 36688 |
| 6 | Alabama Oncology, LLC | Montgomery | Alabama | United States | 36106-2801 |
| 7 | Radiation Oncology Associates of West Alabama | Tuscallosa | Alabama | United States | 35401 |
| 8 | Providence Cancer Therapy Center | Anchorage | Alaska | United States | 99508 |
| 9 | CCOP - Scottsdale Oncology Program | Scottsdale | Arizona | United States | 85259-5404 |
| 10 | Arizona Cancer Center | Tucson | Arizona | United States | 85724 |
| 11 | Providence Saint Joseph Medical Center - Burbank | Burbank | California | United States | 91505 |
| 12 | Mount Diablo Medical Center | Concord | California | United States | 94524-4110 |
| 13 | Beckman Research Institute, City of Hope | Duarte | California | United States | 91010 |
| 14 | California Cancer Center | Fresno | California | United States | 93720 |
| 15 | Saint Agnes Cancer Center | Fresno | California | United States | 93720 |
| 16 | Glendale Memorial Hospital and Health Center | Glendale | California | United States | 91204 |
| 17 | Sutter Health Western Division Cancer Research Group | Greenbrae | California | United States | 94904 |
| 18 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 19 | Veterans Affairs Medical Center - Long Beach | Long Beach | California | United States | 90822 |
| 20 | Kaiser Permanente Medical Center - Los Angeles | Los Angeles | California | United States | 90027 |
| 21 | USC/Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033-0800 |
| 22 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
| 23 | Veterans Affairs Outpatient Clinic - Martinez | Martinez | California | United States | 94553 |
| 24 | CCOP - Bay Area Tumor Institute | Oakland | California | United States | 94609-3305 |
| 25 | Cancer Care Center | Pomona | California | United States | 91767 |
| 26 | Mercy Medical Center - Redding | Redding | California | United States | 96099-6009 |
| 27 | Radiation Oncology Center - Sacramento | Sacramento | California | United States | 95816 |
| 28 | UCSF Cancer Center and Cancer Research Institute | San Francisco | California | United States | 94115-0128 |
| 29 | Santa Cruz Radiation Oncology Medical Group, Inc. | Santa Cruz | California | United States | 95065 |
| 30 | CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | United States | 95403 |
| 31 | Stanford University | Stanford | California | United States | 94305 |
| 32 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
| 33 | Radiation Oncology Center - Walnut Creek | Walnut Creek | California | United States | 94598 |
| 34 | Memorial Hospital Cancer Center | Colorado Springs | Colorado | United States | 80909 |
| 35 | University of Colorado Cancer Center | Denver | Colorado | United States | 80262 |
| 36 | Bridgeport Hospital | Bridgeport | Connecticut | United States | 06610 |
| 37 | Whittingham Cancer Center | Norwalk | Connecticut | United States | 06856 |
| 38 | CCOP - Christiana Care Health Services | Wilmington | Delaware | United States | 19899 |
| 39 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5000 |
| 40 | Lykes Center for Radiation Therapy | Clearwater | Florida | United States | 33757-0210 |
| 41 | Halifax Medical Center | Daytona Beach | Florida | United States | 32114 |
| 42 | Radiation Therapy Associates - Fort Myers | Fort Myers | Florida | United States | 33901 |
| 43 | University of Florida Health Science Center | Gainesville | Florida | United States | 32610-0296 |
| 44 | Health First Holmes Regional Medical Center | Melbourne | Florida | United States | 32901 |
| 45 | CCOP - Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 46 | Sylvester Cancer Center, University of Miami | Miami | Florida | United States | 33136 |
| 47 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
| 48 | Florida Radiation Oncology Group | Orange Park | Florida | United States | 32073 |
| 49 | MD Anderson Cancer Center Orlando | Orlando | Florida | United States | 32806 |
| 50 | Gulf Coast Cancer Treatment Center | Panama City | Florida | United States | 32405-4587 |
| 51 | West Florida Cancer Institute - Pensacola | Pensacola | Florida | United States | 32514 |
| 52 | Bayfront Medical Center | Saint Petersburg | Florida | United States | 33701 |
| 53 | H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | United States | 33612 |
| 54 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
| 55 | CCOP - Atlanta Regional | Atlanta | Georgia | United States | 30342-1701 |
| 56 | InterCommunity Cancer Center at Rome | Rome | Georgia | United States | 30161 |
| 57 | South Georgia Medical Center | Valdosta | Georgia | United States | 31603 |
| 58 | Northwestern Memorial Hospital | Chicago | Illinois | United States | 60611 |
| 59 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60637 |
| 60 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 61 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 62 | Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068 |
| 63 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 64 | CCOP - Central Illinois | Springfield | Illinois | United States | 62526 |
| 65 | CCOP - Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 66 | St. John's Medical Center | Anderson | Indiana | United States | 46016 |
| 67 | Clarion Health Partners Inc. | Indianapolis | Indiana | United States | 46206-1367 |
| 68 | Community Hospitals of Indianapolis - Regional Cancer Center | Indianapolis | Indiana | United States | 46219 |
| 69 | Ball Memorial Hospital | Muncie | Indiana | United States | 47303-3499 |
| 70 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 71 | St. Joseph's Radiation Oncology Center | South Bend | Indiana | United States | 46617 |
| 72 | CCOP - Iowa Oncology Research Association | Des Moines | Iowa | United States | 10309-1016 |
| 73 | Wendt Regional Cancer Center of Finley Hospital | Dubuque | Iowa | United States | 52001 |
| 74 | University of Iowa Hospitals and Clinics | Iowa City | Iowa | United States | 52242 |
| 75 | Siouxland Hematology-Oncology | Sioux City | Iowa | United States | 51101-1733 |
| 76 | CCOP - Wichita | Wichita | Kansas | United States | 67214-3882 |
| 77 | Medical Center at Bowling Green | Bowling Green | Kentucky | United States | 42102 |
| 78 | Veterans Affairs Medical Center - Lexington | Lexington | Kentucky | United States | 40511-1093 |
| 79 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0084 |
| 80 | James Graham Brown Cancer Center | Louisville | Kentucky | United States | 40202 |
| 81 | Louisville Radiation Oncology | Louisville | Kentucky | United States | 40215 |
| 82 | Merle M. Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 83 | Western Baptist Hospital | Paducah | Kentucky | United States | 42001 |
| 84 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 85 | Romagosa Radiation Oncology Center | Lafayette | Louisiana | United States | 70501 |
| 86 | East Jefferson General Hospital | Metairie | Louisiana | United States | 70011 |
| 87 | MBCCOP - LSU Medical Center | New Orleans | Louisiana | United States | 70112 |
| 88 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 89 | Maine Medical Center | Portland | Maine | United States | 04102 |
| 90 | Anne Arundel Oncology Center | Annapolis | Maryland | United States | 21401 |
| 91 | Marlene & Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | United States | 21201 |
| 92 | Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | United States | 21204 |
| 93 | Harbor Hospital Center | Baltimore | Maryland | United States | 21225 |
| 94 | Radiation Oncology Affiliates of Maryland, P.A. | Baltimore | Maryland | United States | 21237 |
| 95 | Johns Hopkins Oncology Center | Baltimore | Maryland | United States | 21287 |
| 96 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 97 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 98 | Joint Center for Radiation Therapy | Boston | Massachusetts | United States | 02215 |
| 99 | Cape Cod Hospital | Hyannis | Massachusetts | United States | 02601 |
| 100 | Veterans Affairs Medical Center - Ann Arbor | Ann Arbor | Michigan | United States | 48105 |
| 101 | CCOP - Ann Arbor Regional | Ann Arbor | Michigan | United States | 48106 |
| 102 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109-0752 |
| 103 | Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 104 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 105 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 106 | CCOP - Kalamazoo | Kalamazoo | Michigan | United States | 49007-3731 |
| 107 | Marquette General Hospital | Marquette | Michigan | United States | 49855 |
| 108 | St. Mary's Medical Center | Saginaw | Michigan | United States | 48601 |
| 109 | CCOP - Duluth | Duluth | Minnesota | United States | 55805 |
| 110 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 111 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 112 | Ellis Fischel Cancer Center - Columbia | Columbia | Missouri | United States | 65203 |
| 113 | CCOP - Kansas City | Kansas City | Missouri | United States | 64131 |
| 114 | Veterans Affairs Medical Center - Saint Louis | Saint Louis | Missouri | United States | 63106 |
| 115 | St. Louis University Health Sciences Center | Saint Louis | Missouri | United States | 63110-0250 |
| 116 | Mallinckrodt Institute of Radiology | Saint Louis | Missouri | United States | 63110 |
| 117 | Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 118 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 119 | Methodist Cancer Center - Omaha | Omaha | Nebraska | United States | 68114 |
| 120 | CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68131 |
| 121 | CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 122 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756 |
| 123 | Elliot Regional Cancer Center | Manchester | New Hampshire | United States | 03103 |
| 124 | Veterans Affairs Medical Center - East Orange | East Orange | New Jersey | United States | 07018-1095 |
| 125 | John F. Kennedy Medical Center | Edison | New Jersey | United States | 08818 |
| 126 | Elizabeth General Medical Center - West | Elizabeth | New Jersey | United States | 07201 |
| 127 | CCOP - Northern New Jersey | Hackensack | New Jersey | United States | 07601 |
| 128 | South Jersey Hospital - Millville | Millville | New Jersey | United States | 08332 |
| 129 | Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County | Mount Holly | New Jersey | United States | 08060 |
| 130 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 131 | St. Francis Medical Center | Trenton | New Jersey | United States | 08629 |
| 132 | Saint Joseph Medical Center | Albuquerque | New Mexico | United States | 87102 |
| 133 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
| 134 | Veterans Affairs Medical Center - Albany | Albany | New York | United States | 12208 |
| 135 | Albert Einstein Comprehensive Cancer Center | Bronx | New York | United States | 10461 |
| 136 | State University of New York Health Science Center at Brooklyn | Brooklyn | New York | United States | 11203 |
| 137 | New York Methodist Hospital | Brooklyn | New York | United States | 11215-3609 |
| 138 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
| 139 | CCOP - North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 140 | Kaplan Cancer Center | New York | New York | United States | 10016 |
| 141 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
| 142 | Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | United States | 12901 |
| 143 | Vassar Brothers Hospital | Poughkeepsie | New York | United States | 12601 |
| 144 | Genesee Hospital - Rochester | Rochester | New York | United States | 14607 |
| 145 | University of Rochester Cancer Center | Rochester | New York | United States | 14642 |
| 146 | New York Medical College | Valhalla | New York | United States | 10595 |
| 147 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
| 148 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
| 149 | CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | United States | 27104-4241 |
| 150 | Comprehensive Cancer Center of Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | United States | 27157-1082 |
| 151 | Quain & Ramstad Clinic, P.C. | Bismarck | North Dakota | United States | 58501 |
| 152 | Meritcare Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 153 | UNI-MED Medical Center | Minot | North Dakota | United States | 58701 |
| 154 | Akron General Medical Center | Akron | Ohio | United States | 44302 |
| 155 | Akron City Hospital | Akron | Ohio | United States | 44309 |
| 156 | Christ Hospital | Cincinnati | Ohio | United States | 45219 |
| 157 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
| 158 | CCOP - Columbus | Columbus | Ohio | United States | 43206 |
| 159 | Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | United States | 43210 |
| 160 | Veterans Affairs Medical Center - Dayton | Dayton | Ohio | United States | 45428 |
| 161 | CCOP - Dayton | Kettering | Ohio | United States | 45429 |
| 162 | CCOP - Toledo Community Hospital Oncology Program | Toledo | Ohio | United States | 43623-3456 |
| 163 | St. John Medical Center | Tulsa | Oklahoma | United States | 74104 |
| 164 | Samaritan Regional Cancer Center | Corvallis | Oregon | United States | 97339 |
| 165 | CCOP - Columbia River Program | Portland | Oregon | United States | 97213 |
| 166 | Penn State Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-2001 |
| 167 | Mercy Catholic Medical Center, Mercy Fitzgerald Divison | Darby | Pennsylvania | United States | 19023 |
| 168 | Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 169 | Penn State Geisinger Cancer Center | Hershey | Pennsylvania | United States | 17033 |
| 170 | Allegheny University Hospitals- Hahnemann | Philadelphia | Pennsylvania | United States | 19102-1192 |
| 171 | University of Pennsylvania Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 172 | Veterans Affairs Medical Center - Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 173 | Kimmel Cancer Center of Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107 |
| 174 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 175 | Albert Einstein Cancer Center | Philadelphia | Pennsylvania | United States | 19141 |
| 176 | University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | United States | 15213 |
| 177 | Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 178 | Reading Hospital and Medical Center | Reading | Pennsylvania | United States | 19612-6052 |
| 179 | Mercy Hospital Cancer Center - Scranton | Scranton | Pennsylvania | United States | 18501 |
| 180 | Grand View Hospital | Sellersville | Pennsylvania | United States | 18960 |
| 181 | Wilkes Barre General Hospital | Wilkes-Barre | Pennsylvania | United States | 18764 |
| 182 | CCOP - MainLine Health | Wynnewood | Pennsylvania | United States | 19096 |
| 183 | York Hospital | York | Pennsylvania | United States | 17315 |
| 184 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
| 185 | CCOP - Greenville | Greenville | South Carolina | United States | 29615 |
| 186 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 187 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57709 |
| 188 | Jackson-Madison County General Hospital | Jackson | Tennessee | United States | 38301 |
| 189 | Baptist Regional Cancer Center - Knoxville | Knoxville | Tennessee | United States | 37901 |
| 190 | CCOP - Baptist Cancer Institute | Memphis | Tennessee | United States | 38117 |
| 191 | University of Tennessee, Memphis Cancer Center | Memphis | Tennessee | United States | 38163 |
| 192 | Vanderbilt Cancer Center | Nashville | Tennessee | United States | 37232-6838 |
| 193 | Julie and Ben Rogers Cancer Institute | Beaumont | Texas | United States | 77701 |
| 194 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-1329 |
| 195 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 196 | Wilford Hall - 59th Medical Wing | Lackland Air Force Base | Texas | United States | 78236-5300 |
| 197 | Bayshore Medical Center | Pasadena | Texas | United States | 77504 |
| 198 | Dixie Regional Medical Center | Saint George | Utah | United States | 84770 |
| 199 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 200 | Green Mountain Oncology Group | Rutland | Vermont | United States | 05701 |
| 201 | Veterans Affairs Medical Center - White River Junction | White River Junction | Vermont | United States | 05009 |
| 202 | Martha Jefferson Hospital | Charlottesville | Virginia | United States | 22901 |
| 203 | Cancer Center, University of Virginia HSC | Charlottesville | Virginia | United States | 22908 |
| 204 | Virginia Baptist Hospital | Lynchburg | Virginia | United States | 24503 |
| 205 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-2197 |
| 206 | Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
| 207 | Swedish Hospital Tumor Institute | Seattle | Washington | United States | 98104 |
| 208 | Virginia Mason Medical Center | Seattle | Washington | United States | 98111 |
| 209 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
| 210 | Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 211 | Schiffler Oncology Center | Wheeling | West Virginia | United States | 26003 |
| 212 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-3508 |
| 213 | Gundersen Lutheran Medical Foundation | La Crosse | Wisconsin | United States | 54601 |
| 214 | Veterans Affairs Medical Center - Madison | Madison | Wisconsin | United States | 53705 |
| 215 | Southern Wisconsin Radiotherapy Center | Madison | Wisconsin | United States | 53713 |
| 216 | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792 |
| 217 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449 |
| 218 | Community Memorial Hospital | Menomonee Falls | Wisconsin | United States | 53051 |
| 219 | St. Joseph's Hospital | Milwaukee | Wisconsin | United States | 53210 |
| 220 | Columbia Hospital | Milwaukee | Wisconsin | United States | 53211 |
| 221 | St. Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 222 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 223 | Veterans Affairs Medical Center - Milwaukee (Zablocki) | Milwaukee | Wisconsin | United States | 53295 |
| 224 | Southeastern Wisconsin Regional Cancer Center | Racine | Wisconsin | United States | 53405 |
| 225 | Tom Baker Cancer Center - Calgary | Calgary | Alberta | Canada | T2N 4N2 |
| 226 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
| 227 | British Columbia Cancer Agency - Vancouver Island Cancer Centre | Victoria | British Columbia | Canada | V8R 1J8 |
| 228 | Doctor Leon Richard Oncology Centre | Moncton | New Brunswick | Canada | E1C 8X3 |
| 229 | Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 230 | Nova Scotia Cancer Centre | Halifax | Nova Scotia | Canada | B3H 1V7 |
| 231 | Cancer Care Ontario-Hamilton Regional Cancer Centre | Hamilton | Ontario | Canada | L8V 5C2 |
| 232 | Kingston Regional Cancer Centre | Kingston | Ontario | Canada | K7L 5P9 |
| 233 | Cancer Care Ontario-London Regional Cancer Centre | London | Ontario | Canada | N6A 4L6 |
| 234 | Ottawa Regional Cancer Centre - Civic Campus | Ottawa | Ontario | Canada | K1Y 4K7 |
| 235 | Northeastern Ontario Regional Cancer Centre, Sudbury | Sudbury | Ontario | Canada | P3E 5J1 |
| 236 | Northwestern Ontario Regional Cancer Centre, Thunder Bay | Thunder Bay | Ontario | Canada | P7A 7T1 |
| 237 | Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 238 | McGill University Department of Oncology | Montreal | Quebec | Canada | H2W 1S6 |
| 239 | Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Canada | H2W-W1T8 |
| 240 | Saskatchewan Cancer Agency | Regina | Saskatchewan | Canada | S4S 6X3 |
| 241 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
Sponsors and Collaborators
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
- Eastern Cooperative Oncology Group
- Radiation Therapy Oncology Group
- North Central Cancer Treatment Group
Investigators
- Study Chair: Jemi Olak, MD, Kern Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Alliance for Clinical Trials in Oncology
ClinicalTrials.gov Identifier:
NCT00002622
Other Study ID Numbers:
- CALGB-9334
- U10CA031946
- CLB-9334
- E-C9334
- NCCTG-C9334
- RTOG-9511
- CDR0000063982
First Posted:
Aug 31, 2004
Last Update Posted:
Jun 28, 2016
Last Verified:
Jun 1, 2016
Keywords provided by Alliance for Clinical Trials in Oncology
Additional relevant MeSH terms: