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Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients With Pancreatic Cancer That Has Spread With Inherited BRCA Mutations

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT04548752
Collaborator
(none)
88
Enrollment
501
Locations
2
Arms
51.8
Anticipated Duration (Months)
0.2
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. These proteins help repair damaged deoxyribonucleic acid (DNA) and, therefore, play a role in ensuring the stability of each cell's genetic material. When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. As a result, cells are more likely to develop additional genetic alterations that can lead to some types of cancer, including pancreatic cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Olaparib is an inhibitor of PARP, a protein that helps repair damaged DNA. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. The addition of pembrolizumab to the usual treatment of olaparib may help to shrink tumors in patients with metastatic pancreatic cancer with BRCA1 or BRCA2 mutations.

Condition or Disease Intervention/Treatment Phase
Phase 2

Detailed Description

PRIMARY OBJECTIVE:
  1. To evaluate the progression free survival (PFS) of advanced pancreatic cancer patients with germline BRCA1 or BRCA2 mutations treated with olaparib + pembrolizumab compared to olaparib alone as maintenance therapy.
SECONDARY OBJECTIVES:

  1. To evaluate the safety and tolerability associated with the combination of olaparib + pembrolizumab versus (vs.) olaparib alone as maintenance therapy.

  2. To evaluate the overall survival (OS) of patients treated with olaparib + pembrolizumab compared to olaparib alone as maintenance therapy.

  3. To evaluate the overall response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, including confirmed and unconfirmed, complete and partial response, of patients treated with olaparib + pembrolizumab compared to olaparib alone, in the subset of patients with measurable disease.

  4. To evaluate the overall response rate (ORR) by immune RECIST, including confirmed and unconfirmed, complete and partial response, of patients treated with olaparib + pembrolizumab compared to olaparib alone, in the subset of patients with measurable disease.

  5. To evaluate the duration of response (DoR) by RECIST 1.1 in patients treated with olaparib

  • pembrolizumab compared to olaparib alone.
BANKING OBJECTIVE:
  1. To bank tissue and blood specimens for future correlative studies.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive olaparib orally (PO) twice daily (BID) on days 1-21 and pembrolizumab intravenously (IV) over 30 minutes on day 1. Treatment repeats every 21 days for up to 18 cycles in the absence of disease progression or unacceptable toxicity. Beginning in cycle 19, patients receive olaparib PO BID on days 1-42 and pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive olaparib PO BID on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed for 30 days and every 6 months for 3 years from the date of randomization.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
88 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Randomized Phase II Clinical Trial of Olaparib + Pembrolizumab vs. Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients With Germline BRCA1 or BRCA2 Mutations
Actual Study Start Date :
Dec 4, 2020
Anticipated Primary Completion Date :
Mar 31, 2025
Anticipated Study Completion Date :
Mar 31, 2025

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm A (olaparib, pembrolizumab)

Patients receive olaparib PO BID on days 1-21 and pembrolizumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 18 cycles in the absence of disease progression or unacceptable toxicity. Beginning in cycle 19, patients receive olaparib PO BID on days 1-42 and pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.

Drug: Olaparib
Given PO
Other Names:
  • AZD 2281
  • AZD-2281
  • AZD2281
  • KU-0059436
  • Lynparza
  • PARP Inhibitor AZD2281

    • Biological: Pembrolizumab
    Given IV
    Other Names:
  • Keytruda
  • Lambrolizumab
  • MK-3475
  • SCH 900475

    		•
    Active Comparator: Arm B (olaparib)

    Patients receive olaparib PO BID on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

    Drug: Olaparib
    Given PO
    Other Names:
  • AZD 2281
  • AZD-2281
  • AZD2281
  • KU-0059436
  • Lynparza
  • PARP Inhibitor AZD2281

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Progression-free survival (PFS) [Up to 3 years]

      Primary analysis of PFS will be conducted in all eligible patients according to the intent-to-treat principle using a log rank test stratified by first line chemotherapy, performance status and disease status after first line platinum-based treatment. Distributions of PFS by treatment arm will be estimated using the method of Kaplan-Meier.

    Secondary Outcome Measures

    1. Incidence of adverse events [Up to 3 years]

      Will utilize the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 for toxicity and serious adverse event reporting.

    2. Overall survival [Up to 3 years]

      Distributions of overall survival in each arm will be estimated using the method of Kaplan-Meier and compared using the stratified log-rank test.

    3. Overall response rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) [Up to 3 years]

      Measured per RECIST 1.1. ORR will be estimated in the subset of patients with measurable disease. Assuming 90% of patients (n=35 per arm) will present with measurable disease, ORR can be estimated to within 18% (95% confidence interval) and will be compared by treatment arm using logistic regression.

    4. ORR per Immune-Modified Response Evaluation Criteria in Solid Tumors (iRECIST) [Up to 3 years]

      Measured per iRECIST. ORR will be estimated in the subset of patients with measurable disease. Assuming 90% of patients (n=35 per arm) will present with measurable disease, ORR can be estimated to within 18% (95% confidence interval) and will be compared by treatment arm using logistic regression.

    5. Duration of response (DoR) [Up to 3 years]

      Distributions of DoR in each arm will be estimated using the method of Kaplan-Meier and compared using the stratified log-rank test.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patient must have a histologic or cytologic diagnosis of pancreatic adenocarcinoma. Patients with neuroendocrine tumors, acinar cell and adenosquamous carcinomas are excluded. All disease must be assessed and documented on the Baseline Tumor Assessment Form

    • Patients must have one of the following mutations: germline mutation in BRCA 1 or 2 that was tested in a Clinical Laboratory Improvement Act (CLIA) certified lab defined as positive and/or deleterious (that is, pathogenic or likely pathogenic variant). (NOTE: Patients with tumor somatic mutations are not eligible)

    • Patient must have metastatic disease and received first line platinum-based chemotherapy (i.e. fluorouracil, irinotecan, leucovorin and oxaliplatin [FOLFIRINOX], leucovorin calcium, 5-fluorouracil, and oxaliplatin [FOLFOX], gemcitabine + nab-paclitaxel + cisplatin or gemcitabine + cisplatin)

    • Patients must have had a computed tomography (CT) or magnetic resonance imaging (MRI) showing stable or responding disease on first line platinum-based chemotherapy within 30 days prior to registration

    • Patients with known human immunodeficiency virus (HIV)-infection are eligible providing they are on effective anti-retroviral therapy and have undetectable viral load at their most recent viral load test and within 6 months prior to registration

    • Patients with history of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load within 30 days prior to registration

    • Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment must have an undetectable HCV viral load within 30 days prior to registration

    • Patients must have received at least 16 weeks of first line platinum-based chemotherapy for metastatic disease. Patients may have also received one cycle of treatment (no more than 4 weeks) with gemcitabine + nab-paclitaxel while waiting for germline test results, prior to platinum-based therapy

    • Patients' last chemotherapy treatment must be within 30 days prior to registration

    • Patients must have resolved or stable =< grade 1 toxicity from prior administration of another investigational drug and/or prior anti-cancer treatment, excluding neuropathy and alopecia

    • Zubrod performance status of 0-1

    • Patients must be >= 18 years old

    • Patients must have a complete medical history and physical exam within 28 days prior to registration

    • Absolute neutrophil count >= 1.5 x 10^3/uL (within 14 days of registration)

    • Platelets >= 100 x 10^3/uL (within 14 days of registration)

    • Total bilirubin =< 1.5 institutional upper limit of normal (ULN) (within 14 days of registration)

    • Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x institutional ULN (within 14 days of registration)

    • Albumin >= 3.0 g/dL (within 14 days of registration)

    • Hemoglobin >= 9.0 g/dL (within 14 days of registration)

    • Participants must have a serum creatinine =< the institutional (I)ULN OR measured OR calculated creatinine clearance >= 50 mL/min using the following Cockcroft-Gault Formula. This specimen must have been drawn and processed within 14 days prior to registration

    • Patients must have CA19-9 obtained within 42 days prior to registration

    • Patients must be able to swallow and retain oral medications and have no known gastrointestinal disorders likely to interfere with absorption of the study medication

    • Participants with a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial provided it does not require concurrent therapy

    • Patients must be offered the opportunity to participate in specimen banking of formalin-fixed paraffin-embedded (FFPE) tissue and whole blood. If a patient is unable to submit archival tissue, should the patient need to undergo a standard of care biopsy per National Comprehensive Cancer Network (NCCN) guidelines, patients must then be offered the opportunity to submit the fresh tumor tissue from that biopsy. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System

    • Patients must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. For participants with impaired decision making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Canada Industrial Relations Board (CIRB) regulations

    • As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    Exclusion Criteria:

    • Patients must not have a known hypersensitivity to olaparib or any of the excipients of the product

    • Patients must not be planning to receive strong or moderate CYP3A inhibitors or inducers while on olaparib treatment. Patients receiving strong or moderate CYP3A inhibitors must discontinue use at least 2 weeks prior to receiving olaparib. Patients receiving strong or moderate CYP3A inducers must discontinue use at least 5 weeks prior to receiving olaparib. Medications should be checked using a frequently updated medical reference for a list of drugs to avoid

    • Patients must not have received live vaccines within 42 days prior to randomization and must not be planning to receive live virus or live bacterial vaccines while receiving study treatment and during the 30 day follow up period. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed. Coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine is allowed

    • Patients must not have had prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent, or any other immune checkpoint inhibitors

    • Patients must not have had prior therapy with PARP inhibitors

    • Patients must not have had a prior diagnosis of immunodeficiency or receiving systemic steroid therapy (defined as >= 10 mg prednisone or equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment

    • Participants must not be pregnant or nursing due to the possibility of harm to the fetus or nursing infant from this treatment regimen. Women of childbearing potential must have a negative urine or serum pregnancy test within 28 days prior to registration. Women/men of reproductive potential must have agreed to use an effective contraceptive method for the course of the study through 6 months after the last dose of study medication. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures, he/she is responsible for beginning contraceptive measures. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately

    • Patients must not have a history of (non-infectious) pneumonitis that required steroids or current pneumonitis

    • Patients must not have an active infection requiring systemic therapy

    • Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
    10 Kingman Regional Medical Center Kingman Arizona United States 86401
    11 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    12 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    13 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    14 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    15 PCR Oncology Arroyo Grande California United States 93420
    16 Sutter Auburn Faith Hospital Auburn California United States 95602
    17 Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California United States 95603
    18 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    19 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    20 Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California United States 95682
    21 Eden Hospital Medical Center Castro Valley California United States 94546
    22 Sutter Davis Hospital Davis California United States 95616
    23 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    24 Palo Alto Medical Foundation-Fremont Fremont California United States 94538
    25 Memorial Medical Center Modesto California United States 95355
    26 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    27 Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California United States 94040
    28 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    29 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    30 Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California United States 95661
    31 Sutter Roseville Medical Center Roseville California United States 95661
    32 Sutter Medical Center Sacramento Sacramento California United States 95816
    33 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    34 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    35 Mills Health Center San Mateo California United States 94401
    36 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    37 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    38 Sutter Pacific Medical Foundation Santa Rosa California United States 95403
    39 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    40 Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California United States 95687
    41 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    42 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    43 The Medical Center of Aurora Aurora Colorado United States 80012
    44 University of Colorado Hospital Aurora Colorado United States 80045
    45 Boulder Community Foothills Hospital Boulder Colorado United States 80303
    46 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    47 Rocky Mountain Cancer Centers - Centennial Centennial Colorado United States 80112
    48 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    49 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    50 The Women's Imaging Center Denver Colorado United States 80209
    51 Porter Adventist Hospital Denver Colorado United States 80210
    52 Colorado Blood Cancer Institute Denver Colorado United States 80218
    53 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    54 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    55 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    56 Rose Medical Center Denver Colorado United States 80220
    57 Western Surgical Care Denver Colorado United States 80220
    58 Mercy Medical Center Durango Colorado United States 81301
    59 Southwest Oncology PC Durango Colorado United States 81301
    60 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    61 Rocky Mountain Cancer Centers - Swedish Englewood Colorado United States 80113
    62 Swedish Medical Center Englewood Colorado United States 80113
    63 The Melanoma and Skin Cancer Institute Englewood Colorado United States 80113
    64 Poudre Valley Hospital Fort Collins Colorado United States 80524
    65 Cancer Care and Hematology-Fort Collins Fort Collins Colorado United States 80528
    66 North Colorado Medical Center Greeley Colorado United States 80631
    67 UCHealth Greeley Hospital Greeley Colorado United States 80631
    68 UCHealth Highlands Ranch Hospital Highlands Ranch Colorado United States 80129
    69 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    70 Saint Anthony Hospital Lakewood Colorado United States 80228
    71 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    72 Littleton Adventist Hospital Littleton Colorado United States 80122
    73 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    74 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    75 Longmont United Hospital Longmont Colorado United States 80501
    76 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    77 Medical Center of the Rockies Loveland Colorado United States 80538
    78 McKee Medical Center Loveland Colorado United States 80539
    79 Parker Adventist Hospital Parker Colorado United States 80138
    80 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    81 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    82 Danbury Hospital Danbury Connecticut United States 06810
    83 Norwalk Hospital Norwalk Connecticut United States 06856
    84 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    85 Helen F Graham Cancer Center Newark Delaware United States 19713
    86 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    87 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    88 Sibley Memorial Hospital Washington District of Columbia United States 20016
    89 Mount Sinai Comprehensive Cancer Center at Aventura Aventura Florida United States 33180
    90 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    91 Mount Sinai Medical Center Miami Beach Florida United States 33140
    92 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    93 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    94 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    95 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    96 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    97 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    98 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    99 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    100 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    101 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    102 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    103 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    104 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    105 Saint Anthony's Health Alton Illinois United States 62002
    106 Rush - Copley Medical Center Aurora Illinois United States 60504
    107 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    108 Illinois CancerCare-Canton Canton Illinois United States 61520
    109 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    110 SIH Cancer Institute Carterville Illinois United States 62918
    111 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    112 Centralia Oncology Clinic Centralia Illinois United States 62801
    113 Northwestern University Chicago Illinois United States 60611
    114 Carle on Vermilion Danville Illinois United States 61832
    115 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    116 Decatur Memorial Hospital Decatur Illinois United States 62526
    117 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    118 Carle Physician Group-Effingham Effingham Illinois United States 62401
    119 Crossroads Cancer Center Effingham Illinois United States 62401
    120 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    121 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    122 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    123 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    124 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    125 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    126 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    127 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    128 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    129 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    130 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    131 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    132 Illinois CancerCare-Peru Peru Illinois United States 61354
    133 Valley Radiation Oncology Peru Illinois United States 61354
    134 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    135 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    136 Springfield Clinic Springfield Illinois United States 62702
    137 Memorial Medical Center Springfield Illinois United States 62781
    138 Carle Cancer Center Urbana Illinois United States 61801
    139 The Carle Foundation Hospital Urbana Illinois United States 61801
    140 Illinois CancerCare - Washington Washington Illinois United States 61571
    141 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    142 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    143 Reid Health Richmond Indiana United States 47374
    144 Mary Greeley Medical Center Ames Iowa United States 50010
    145 McFarland Clinic PC - Ames Ames Iowa United States 50010
    146 McFarland Clinic PC-Boone Boone Iowa United States 50036
    147 Saint Anthony Regional Hospital Carroll Iowa United States 51401
    148 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    149 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    150 Jennie Edmundson Memorial Hospital Council Bluffs Iowa United States 51502
    151 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    152 Heartland Oncology and Hematology LLP Council Bluffs Iowa United States 51503
    153 Greater Regional Medical Center Creston Iowa United States 50801
    154 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    155 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    156 Broadlawns Medical Center Des Moines Iowa United States 50314
    157 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    158 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    159 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    160 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    161 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    162 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    163 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    164 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    165 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    166 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    167 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    168 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    169 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    170 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    171 Saint Joseph Hospital East Lexington Kentucky United States 40509
    172 Saint Joseph London London Kentucky United States 40741
    173 Jewish Hospital Louisville Kentucky United States 40202
    174 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    175 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    176 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    177 Hickman Cancer Center Adrian Michigan United States 49221
    178 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    179 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    180 Bronson Battle Creek Battle Creek Michigan United States 49017
    181 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    182 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    183 Saint Joseph Mercy Canton Canton Michigan United States 48188
    184 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    185 Caro Cancer Center Caro Michigan United States 48723
    186 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    187 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    188 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    189 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    190 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    191 Ascension Saint John Hospital Detroit Michigan United States 48236
    192 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    193 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    194 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    195 Genesee Hematology Oncology PC Flint Michigan United States 48503
    196 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    197 Hurley Medical Center Flint Michigan United States 48503
    198 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    199 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    200 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    201 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    202 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    203 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    204 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    205 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    206 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    207 Borgess Medical Center Kalamazoo Michigan United States 49048
    208 Sparrow Hospital Lansing Michigan United States 48912
    209 Hope Cancer Clinic Livonia Michigan United States 48154
    210 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    211 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    212 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    213 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    214 Toledo Clinic Cancer Centers-Monroe Monroe Michigan United States 48162
    215 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    216 Lakeland Hospital Niles Niles Michigan United States 49120
    217 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    218 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    219 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    220 Hope Cancer Center Pontiac Michigan United States 48341
    221 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    222 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    223 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    224 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    225 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    226 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    227 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    228 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    229 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    230 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    231 Munson Medical Center Traverse City Michigan United States 49684
    232 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    233 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    234 Macomb Hematology Oncology PC Warren Michigan United States 48093
    235 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    236 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    237 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    238 Metro Health Hospital Wyoming Michigan United States 49519
    239 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    240 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    241 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    242 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    243 Cambridge Medical Center Cambridge Minnesota United States 55008
    244 Mercy Hospital Coon Rapids Minnesota United States 55433
    245 Fairview Southdale Hospital Edina Minnesota United States 55435
    246 Unity Hospital Fridley Minnesota United States 55432
    247 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    248 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    249 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    250 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    251 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    252 Health Partners Inc Minneapolis Minnesota United States 55454
    253 Monticello Cancer Center Monticello Minnesota United States 55362
    254 New Ulm Medical Center New Ulm Minnesota United States 56073
    255 Fairview Northland Medical Center Princeton Minnesota United States 55371
    256 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    257 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    258 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    259 Regions Hospital Saint Paul Minnesota United States 55101
    260 United Hospital Saint Paul Minnesota United States 55102
    261 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    262 Lakeview Hospital Stillwater Minnesota United States 55082
    263 Ridgeview Medical Center Waconia Minnesota United States 55387
    264 Rice Memorial Hospital Willmar Minnesota United States 56201
    265 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    266 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    267 Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi United States 39705
    268 Baptist Cancer Center-Grenada Grenada Mississippi United States 38901
    269 Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi United States 38655
    270 Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi United States 38671
    271 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    272 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    273 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    274 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    275 Parkland Health Center - Farmington Farmington Missouri United States 63640
    276 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    277 Freeman Health System Joplin Missouri United States 64804
    278 Mercy Hospital Joplin Joplin Missouri United States 64804
    279 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    280 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    281 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    282 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    283 Mercy Hospital South Saint Louis Missouri United States 63128
    284 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    285 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    286 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    287 Mercy Hospital Springfield Springfield Missouri United States 65804
    288 CoxHealth South Hospital Springfield Missouri United States 65807
    289 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    290 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    291 Mercy Hospital Washington Washington Missouri United States 63090
    292 Community Hospital of Anaconda Anaconda Montana United States 59711
    293 Billings Clinic Cancer Center Billings Montana United States 59101
    294 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    295 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    296 Great Falls Clinic Great Falls Montana United States 59405
    297 Kalispell Regional Medical Center Kalispell Montana United States 59901
    298 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    299 Community Medical Hospital Missoula Montana United States 59804
    300 CHI Health Saint Francis Grand Island Nebraska United States 68803
    301 CHI Health Good Samaritan Kearney Nebraska United States 68847
    302 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    303 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    304 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    305 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    306 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    307 Creighton University Medical Center Omaha Nebraska United States 68131
    308 Midlands Community Hospital Papillion Nebraska United States 68046
    309 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    310 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    311 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    312 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    313 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    314 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    315 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    316 GenesisCare USA - Henderson Henderson Nevada United States 89074
    317 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    318 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    319 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    320 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    321 Desert West Surgery Las Vegas Nevada United States 89102
    322 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    323 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    324 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    325 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    326 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    327 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    328 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    329 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    330 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    331 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    332 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    333 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    334 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    335 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    336 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    337 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    338 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    339 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    340 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    341 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    342 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    343 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    344 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    345 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    346 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    347 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    348 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    349 University Cancer Center Las Vegas Nevada United States 89169
    350 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    351 Renown Regional Medical Center Reno Nevada United States 89502
    352 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    353 Radiation Oncology Associates Reno Nevada United States 89509
    354 Roswell Park Cancer Institute Buffalo New York United States 14263
    355 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    356 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    357 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    358 Vidant Oncology-Kenansville Kenansville North Carolina United States 28349
    359 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    360 Vidant Oncology-Richlands Richlands North Carolina United States 28574
    361 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    362 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    363 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    364 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    365 Miami Valley Hospital South Centerville Ohio United States 45459
    366 Adena Regional Medical Center Chillicothe Ohio United States 45601
    367 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    368 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    369 Bethesda North Hospital Cincinnati Ohio United States 45242
    370 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    371 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    372 Mount Carmel East Hospital Columbus Ohio United States 43213
    373 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    374 Riverside Methodist Hospital Columbus Ohio United States 43214
    375 Grant Medical Center Columbus Ohio United States 43215
    376 The Mark H Zangmeister Center Columbus Ohio United States 43219
    377 Mount Carmel Health Center West Columbus Ohio United States 43222
    378 Doctors Hospital Columbus Ohio United States 43228
    379 Miami Valley Hospital Dayton Ohio United States 45409
    380 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    381 Miami Valley Hospital North Dayton Ohio United States 45415
    382 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    383 Grady Memorial Hospital Delaware Ohio United States 43015
    384 Dublin Methodist Hospital Dublin Ohio United States 43016
    385 Armes Family Cancer Center Findlay Ohio United States 45840
    386 Blanchard Valley Hospital Findlay Ohio United States 45840
    387 Orion Cancer Care Findlay Ohio United States 45840
    388 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    389 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    390 Central Ohio Breast and Endocrine Surgery Gahanna Ohio United States 43230
    391 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    392 Wayne Hospital Greenville Ohio United States 45331
    393 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    394 Greater Dayton Cancer Center Kettering Ohio United States 45409
    395 Kettering Medical Center Kettering Ohio United States 45429
    396 Fairfield Medical Center Lancaster Ohio United States 43130
    397 Saint Rita's Medical Center Lima Ohio United States 45801
    398 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    399 Marietta Memorial Hospital Marietta Ohio United States 45750
    400 OhioHealth Marion General Hospital Marion Ohio United States 43302
    401 Knox Community Hospital Mount Vernon Ohio United States 43050
    402 Licking Memorial Hospital Newark Ohio United States 43055
    403 Newark Radiation Oncology Newark Ohio United States 43055
    404 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    405 Springfield Regional Cancer Center Springfield Ohio United States 45504
    406 Springfield Regional Medical Center Springfield Ohio United States 45505
    407 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    408 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    409 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    410 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    411 Upper Valley Medical Center Troy Ohio United States 45373
    412 Saint Joseph Warren Hospital Warren Ohio United States 44484
    413 Saint Ann's Hospital Westerville Ohio United States 43081
    414 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    415 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    416 Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma United States 73505
    417 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    418 Integris Southwest Medical Center Oklahoma City Oklahoma United States 73109
    419 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    420 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    421 Saint Charles Health System Bend Oregon United States 97701
    422 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    423 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    424 Bay Area Hospital Coos Bay Oregon United States 97420
    425 Providence Newberg Medical Center Newberg Oregon United States 97132
    426 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    427 Providence Portland Medical Center Portland Oregon United States 97213
    428 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    429 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    430 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    431 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    432 Geisinger Medical Center Danville Pennsylvania United States 17822
    433 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    434 Saint Vincent Hospital Erie Pennsylvania United States 16544
    435 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    436 Jefferson Hospital Jefferson Hills Pennsylvania United States 15025
    437 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    438 Forbes Hospital Monroeville Pennsylvania United States 15146
    439 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    440 Allegheny General Hospital Pittsburgh Pennsylvania United States 15212
    441 West Penn Hospital Pittsburgh Pennsylvania United States 15224
    442 Wexford Health and Wellness Pavilion Wexford Pennsylvania United States 15090
    443 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    444 Avera Cancer Institute-Aberdeen Aberdeen South Dakota United States 57401
    445 Avera Cancer Institute Sioux Falls South Dakota United States 57105
    446 Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee United States 38017
    447 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    448 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    449 Hendrick Medical Center Abilene Texas United States 79601
    450 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    451 Farmington Health Center Farmington Utah United States 84025
    452 University of Utah Sugarhouse Health Center Salt Lake City Utah United States 84106
    453 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    454 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    455 Overlake Medical Center Bellevue Washington United States 98004
    456 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    457 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    458 Harrison Medical Center Bremerton Washington United States 98310
    459 Highline Medical Center-Main Campus Burien Washington United States 98166
    460 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    461 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    462 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    463 Providence Regional Cancer Partnership Everett Washington United States 98201
    464 Saint Francis Hospital Federal Way Washington United States 98003
    465 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    466 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    467 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    468 Saint Clare Hospital Lakewood Washington United States 98499
    469 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    470 Jefferson Healthcare Port Townsend Washington United States 98368
    471 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    472 Valley Medical Center Renton Washington United States 98055
    473 Pacific Gynecology Specialists Seattle Washington United States 98104
    474 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    475 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    476 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    477 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    478 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    479 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    480 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    481 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    482 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    483 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    484 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    485 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    486 Mayo Clinic Health System-Eau Claire Clinic Eau Claire Wisconsin United States 54701
    487 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    488 Mayo Clinic Health System-Franciscan Healthcare La Crosse Wisconsin United States 54601
    489 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    490 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    491 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    492 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    493 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    494 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    495 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    496 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    497 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    498 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    499 Cheyenne Regional Medical Center-West Cheyenne Wyoming United States 82001
    500 Billings Clinic-Cody Cody Wyoming United States 82414
    501 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Vincent Chung, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT04548752
    Other Study ID Numbers:
    • NCI-2020-06838
    • NCI-2020-06838
    • S2001
    • S2001
    • U10CA180888
    First Posted:
    Sep 16, 2020
    Last Update Posted:
    Aug 24, 2022
    Last Verified:
    Feb 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Pancreatic Neoplasms
    Pembrolizumab
    Olaparib
    Poly(ADP-ribose) Polymerase Inhibitors

    Study Results

    No Results Posted as of Aug 24, 2022