Clincosm LogoSign in Get a demo

Nivolumab in Treating Patients With Localized Kidney Cancer Undergoing Nephrectomy

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Active, not recruiting
CT.gov ID
NCT03055013
Collaborator
Canadian Cancer Trials Group (Other)
766
Enrollment
415
Locations
2
Arms
81.9
Anticipated Duration (Months)
1.8
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase III trial compares nephrectomy (surgery to remove a kidney or part of a kidney) with nivolumab to the usual approach of nephrectomy followed by standard post-operative follow-up and monitoring, in treating patients with kidney cancer that is limited to a certain part of the body (localized). Nivolumab is a drug that may help stimulate the immune system to attack any cancer cells that may remain after surgery. The addition of nivolumab to the usual surgery could prevent the cancer from returning. It is not yet known whether nivolumab and nephrectomy is more effective than nephrectomy alone in treating patients with kidney cancer.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Nephrectomy
  • Biological: Nivolumab
  • Other: Patient Observation
  • Other: Quality-of-Life Assessment
  • Other: Questionnaire Administration
 Phase 3

Detailed Description

PRIMARY OBJECTIVE:
  1. To compare recurrence-free survival (RFS) between patients with renal cell carcinoma randomly assigned to perioperative nivolumab in conjunction with radical or partial nephrectomy with patients randomized to surgery alone.
SECONDARY OBJECTIVES:

  1. To evaluate for differences in recurrence-free survival associated with perioperative nivolumab compared to surgery alone among the subset of patients with clear cell histology.

  2. To compare the overall survival between the two arms. III. To describe the safety and tolerability of perioperative nivolumab.

CORRELATIVE OBJECTIVES:

  1. To correlate the primary tumor's expression of PD-L1 with outcome. II. To correlate the expression of PD-L1 on tumor tissue at nephrectomy and recurrence with outcome.

  2. To archive images for potential central confirmation of recurrence and for future correlative work with American College of Radiology Imaging Network (ACRIN), including markers predicting outcome or response.

  3. To prospectively collect tumor and biologic specimens (e.g., serum, peripheral blood mononuclear cells [PBMCs]) for future correlative studies.

  4. To characterize the pharmacokinetics of nivolumab and explore exposure response relationships with respect to safety and efficacy.

  5. To characterize the immunogenicity of nivolumab.

QUALITY OF LIFE OBJECTIVE:
  1. To evaluate differences in change from baseline in patient-reported symptoms and toxicities among patients randomized to treatment with nivolumab compared to surgery alone.
OTHER EXPLORATORY OBJECTIVES:

  1. To explore descriptively the efficacy of treatment with nivolumab in patients with non-clear cell (including unclassified) histologies.

  2. To characterize the effects of nivolumab on bone metabolism and bone density.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1. Treatment repeats every 14 days for 2 cycles. Patients then undergo partial or radical nephrectomy 7-28 days later. Patient then receive nivolumab over 30 IV on day 1. Treatment repeats every 14 days for 6 cycles, and then every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity.

Patients enrolled after Amendment 4 receive nivolumab IV over 30 minutes on day 1. Patients then undergo partial or radical nephrectomy 7-28 days later. Patients then receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 4 weeks for up to 9 cycles in the absence of disease progression or unacceptable toxicity.

ARM II: Patients undergo partial or radical nephrectomy within 8 weeks after registration followed by observation.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and every 12 months for 5 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
766 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
A Phase 3 RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients With Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)
Actual Study Start Date :
Feb 2, 2017
Anticipated Primary Completion Date :
Nov 30, 2023
Anticipated Study Completion Date :
Nov 30, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (nivolumab, nephrectomy)

Patients receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 14 days for 2 cycles. Patients then undergo partial or radical nephrectomy 7-28 days later. Patients then receive nivolumab over 30 IV on day 1. Treatment repeats every 14 days for 6 cycles, and then every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment 4 receive nivolumab IV over 30 minutes on day 1. Patients then undergo partial or radical nephrectomy 7-28 days later. Patient then receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 4 weeks for up to 9 cycles in the absence of disease progression or unacceptable toxicity.

Procedure: Nephrectomy
Undergo nephrectomy

Biological: Nivolumab
Given IV
Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo

    • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment

    • Other: Questionnaire Administration
    Ancillary studies
    Active Comparator: Arm II (nephrectomy)

    Patients undergo partial or radical nephrectomy within 8 weeks after registration followed by observation.

    Procedure: Nephrectomy
    Undergo nephrectomy

    Other: Patient Observation
    Undergo observation
    Other Names:
  • Active Surveillance
  • deferred therapy
  • expectant management
  • Observation
  • Watchful Waiting

    • Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment

    • Other: Questionnaire Administration
    Ancillary studies

    Outcome Measures

    Primary Outcome Measures

    1. Event-free survival (EFS) [Time from randomization to disease recurrence or death from any cause, assessed up to 10 years]

      Will be assessed among all randomized patients using a stratified log rank test, with nominal one-sided type I error of 2.5%. The type I error will be adjusted for interim analyses.

    Secondary Outcome Measures

    1. Overall survival [Time from randomization to death from any cause, assessed up to 10 years]

    2. RFS among patients with clear cell cancer [Up to 10 years]

      The stratified logrank test will be used.

    3. Incidence of toxicity [Up to 10 years]

      Graded per Common Criteria for Adverse Events (CTCAE) version (v)4.0. (Starting April 1, 2018, Cancer Therapy Evaluation Program Adverse Event Reporting System [CTEP-AERS] reporting will use CTCAE v5). Adverse events will be described separately for patients treated on each arm to evaluate safety and tolerability.

    Other Outcome Measures

    1. Primary tumor's expression of PD-L1 [Baseline to up to 10 years]

      The percentage of cells exhibiting cell-surface staining for PD-L1 will be scored. PD-L1 positivity will be defined per specimen by a 5% expression threshold. Additional analyses will assess the 1% and 10% threshold levels. Information with respect to the relative abundance and location (peritumoral/intratumoral) of immune cell (macrophage and lymphocyte) PD-L1 staining will be captured. The expression-by-treatment interaction will be tested using a proportional hazards model. McNemar's Test will be used to explore categorical changes within each treatment group.

    2. Expression of PD-L1 on tumor tissue at recurrence [Up to 10 years]

    3. Pharmacokinetic analysis of nivolumab [On day 1 of cycles 1-3, 5, 7 and the first 2 follow-up visits]

      Serum concentration analyses for nivolumab will be performed by validated bio-analytical methods for nivolumab.

    4. Change in patient-reported symptoms and toxicities [Baseline to up to 10 years]

      Using the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy (NCCN/FACT) Kidney Symptom Index-19 (NFKSI-19) and items from the PRO-CTCAE pool of items measuring patient-reported toxicity. We will describe the severity, interference, and (as appropriate) frequency rates, along with response rates at each time point. Change in symptoms will be tested using a two-sided Wilcoxon rank sum test with Type I error of 3%. Change in physical function will be tested using a two-sided Wilcoxon rank sum test with Type I error of 1%. Changes in NFKSI-19 and PROMIS Physical Function scores from baseline to pre-nephrectomy among patients randomized to nivolumab and will be explored using a Wilcoxon signed rank test. Differences in scores post-nephrectomy between the arms will be described and tested using a Wilcoxon rank-sum test. Differences in the pattern of change over time in NFKSI-19 and PROMIS Physical Function scores will be examined using mixed effects models.

    5. Absolute T cell clonotype abundance [Up to 10 years]

      Will be determined by assessing the number of unique clonotypes identified. The data will be summarized descriptively and graphically.

    6. Change in T cell repertoire [From diagnosis to on therapy or to time of recurrence, assessed up to 10 years]

      Morisita's distance will be used as utilized by Cha and colleagues. Morisita's distance ranges from 0-1. Zero indicates minimal change in T cell repertoire (TCR) repertoire size (number of unique clonotypes) and 1 indicates maximal change after treatment.

    7. T cell receptor (TCR) diversity using change in repertoire size per patient [Baseline to up to 10 years]

      The top 25% of unique clonotypes will be identified by sorting for clone frequency. Fold change after recurrence will be measured and plotted on a logarithmic scale.

    8. Change in cytokine levels in patients randomized to the nivolumab arm [Baseline to up to 10 years]

      Differences in RFS between patients with and without robust CD8 infiltration will be explored. A Cox proportional hazards model will be used to test the interaction between treatment and cytokine changes.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • ELIGIBILITY CRITERIA FOR RANDOMIZATION:

    • Patients must have a renal mass consistent with a clinical stage >= T2Nx renal cell carcinoma (RCC) or TanyN+ RCC for which radical or partial nephrectomy is planned

    • Patients must have no clinical or radiological evidence of distant metastases (M0) unless the presumed M1 disease is planned to be resected/definitively treated (e.g., thermal ablation, stereotactic radiation) at the same time or up to 12 weeks after the date of the initial procedure such that the patient is considered "no evidence of disease" (M1 NED)

    • Liver, bone, or brain metastases are not permitted

    • No more than 3 metastases are permitted, and all must be able to be removed or definitively treated within 12 weeks of the primary tumor resection

    • If histological confirmation of RCC has not been done within 12 months prior to randomization, patient must be willing to undergo a core biopsy for this purpose if randomized to Arm A

    • NOTE: This histologic confirmation can be a (1) standard of care diagnostic biopsy or (2) a research biopsy or a planned metastasectomy. Tissue must be obtained with results available prior to the neoadjuvant dose

    • Patients randomized to Arm A: core tumor biopsy must have demonstrated RCC of any histology, including sarcomatoid, unclassified, or "unknown histology" (if preoperative biopsy was uninformative) with exception below for non-diagnostic biopsies

    • If the biopsy performed following randomization clearly demonstrates a benign condition, oncocytoma or a different type of cancer that is not RCC, the patient is not eligible and must come off study

    • A non-diagnostic biopsy is considered a good faith effort and does not need to be repeated unless deemed clinically necessary by the treating investigator

    • Patient must not have any prior systemic or local anti-cancer therapy for the current RCC

    • Patient must not have undergone a partial nephrectomy for the current RCC

    • Patient must not have had a metastasectomy for the current RCC diagnosis unless performed to render patient NED (in addition to the planned nephrectomy) within 6 months prior to the current diagnosis

    • Patient must not have received current or past antineoplastic systemic therapies for RCC: i.e., chemotherapy, hormonal therapy, immunotherapy, or standard or investigational agents for treatment of RCC

    • Patient must not have received prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways

    • Patient must be >= 18 years of age. Because no dosing or adverse event data are currently available on the use of nivolumab therapy in patients < 18 years of age, children are excluded from this study

    • Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

    • Patient must not have a prior history of RCC that was treated with curative intent within the past 5 years

    • Patients with a prior RCC that was treated > 5 years before, are eligible if the current tumor is consistent with a new primary in the opinion of the treating investigator

    • Patients with bilateral synchronous RCCs are eligible if they can be resected or definitively treated at the same time or within a 12 week window from time of initial nephrectomy (partial or radical) or procedure and maintain adequate residual renal function; the patient is not eligible if both kidneys are to be completely removed and subsequent hemodialysis will be required

    • Permitted forms of local therapy for second tumor:

    • Partial or radical nephrectomy

    • If kidney tumor is =< 3 cm: thermal ablation (e.g., radiofrequency ablation, cryoablation or stereotactic radiosurgery)

    • Patients cannot have concurrent malignancies, with the following exceptions:

    • Adequately treated basal cell or squamous cell skin cancer

    • In situ cervical cancer

    • A history of superficial Ta urothelial cancer is permitted (as long as not currently undergoing treatment) whereas T1 or greater disease is excluded if < 3 years from diagnosis; concurrent persistent disease is not permitted

    • Adequately treated stage I or II cancer from which the patient is currently in complete remission

    • Any other cancer and stage from which the patient has been disease-free for at least 3 years prior to the time of randomization and as long as they are not receiving any current treatment (e.g. adjuvant or maintenance systemic or local therapy)

    • Concurrent low risk prostate cancer on active surveillance

    • Patient must not have active known or suspected autoimmune disease. The following autoimmune disorders are permitted: patients with vitiligo, type I diabetes mellitus, controlled/stable hypo or hyperthyroidism due to autoimmune or non-autoimmune conditions (hormone replacement is allowed), psoriasis not requiring systemic treatment, or other conditions not expected to recur

    • Patient must not have any ongoing condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications with the exceptions outlined below; patient must not have received any treatment with other immunosuppressive agents within 14 days prior to the first dose of study drug with the following exceptions:

    • Topical, ocular, intra-articular, intranasal, inhaled steroids and adrenal replacement steroid doses > 10 mg daily prednisone or the equivalent are permitted in the absence of active autoimmune disease

    • A brief (less than 3 weeks) course of corticosteroids (any amount) for prophylaxis (for example: contrast dye allergy) or for treatment of non-autoimmune conditions (for example: nausea, delayed-type hypersensitivity reaction caused by a contact allergen) is permitted

    • Patient must not have uncontrolled adrenal insufficiency

    • Patient must not have known evidence of chronic active liver disease or evidence of acute or chronic hepatitis B Virus (HBV) or hepatitis C (HCV); HBV and HCV testing must be completed within 8 weeks prior to randomization

    • NOTE: If the patient has been treated and cured, and the HCV ribonucleic acid (RNA) is undetectable, the patient is eligible for this study

    • Patient must not have any serious intercurrent illness, including ongoing or active infection requiring parenteral antibiotics

    • Patient must not have known evidence of human immunodeficiency virus (HIV) infection, since the effects of nivolumab on anti-retroviral therapy have not been studied; HIV testing is only required if past or current history is suspected

    • Patient must not have any known medical condition (e.g. a condition associated with uncontrolled diarrhea such as ulcerative colitis or acute diverticulitis) that, in the investigator's opinion, would increase the risk associated with study participation or interfere with the interpretation of safety results

    • Patient must not have had any major surgery within 28 days prior to randomization

    • Patient must not be currently enrolled in other clinical trials testing a therapeutic intervention

    • Patient must not have any history of severe hypersensitivity to a monoclonal antibody

    • Patient must have the ability to understand and the willingness to sign a written informed consent document

    • Patients must not be pregnant or breast-feeding, as the effects of nivolumab on the developing human fetus or in the nursing infant are unknown; all patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a patient of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

    • Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception, as described in the informed consent form (ICF), or by abstaining from sexual intercourse for the duration of their participation in the study; patients of childbearing potential must use adequate methods to avoid pregnancy for 5 months after the last dose of nivolumab

    • White blood cells >= 2000/uL (within 8 weeks prior to randomization)

    • Absolute neutrophil count (ANC) >= 1,500/mm^3 (within 8 weeks prior to randomization)

    • Platelet count >= 100,000/mm^3 (within 8 weeks prior to randomization)

    • Hemoglobin >= 9.0 g/dL (within 8 weeks prior to randomization)

    • Serum creatinine =< 1.5 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) >= 40mL/min (within 8 weeks prior to randomization)

    • Total bilirubin =< 1.5 x ULN (except subjects with Gilbert syndrome, who can have total bilirubin < 3.0 x ULN) (within 8 weeks prior to randomization)

    • Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN (within 8 weeks prior to randomization)

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 University of Alabama at Birmingham Cancer Center Birmingham Alabama United States 35233
    2 Veterans Administration Medical Center - Birmingham Birmingham Alabama United States 35233
    3 Banner MD Anderson Cancer Center Gilbert Arizona United States 85234
    4 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    5 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    6 University of Arizona Cancer Center-North Campus Tucson Arizona United States 85719
    7 Kaiser Permanente-Anaheim Anaheim California United States 92806
    8 Sutter Auburn Faith Hospital Auburn California United States 95602
    9 AIS Cancer Center at San Joaquin Community Hospital Bakersfield California United States 93301
    10 Kaiser Permanente-Baldwin Park Baldwin Park California United States 91706
    11 Kaiser Permanente-Bellflower Bellflower California United States 90706
    12 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    13 Mills-Peninsula Medical Center Burlingame California United States 94010
    14 Community Cancer Institute Clovis California United States 93611
    15 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    16 Kaiser Permanente-Fontana Fontana California United States 92335
    17 Kaiser Permanente - Harbor City Harbor City California United States 90710
    18 Kaiser Permanente-Irvine Irvine California United States 92618
    19 UC San Diego Moores Cancer Center La Jolla California United States 92093
    20 Kaiser Permanente Los Angeles Medical Center Los Angeles California United States 90027
    21 USC / Norris Comprehensive Cancer Center Los Angeles California United States 90033
    22 Kaiser Permanente West Los Angeles Los Angeles California United States 90034
    23 Cedars Sinai Medical Center Los Angeles California United States 90048
    24 UCLA / Jonsson Comprehensive Cancer Center Los Angeles California United States 90095
    25 Fremont - Rideout Cancer Center Marysville California United States 95901
    26 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    27 USC Norris Oncology/Hematology-Newport Beach Newport Beach California United States 92663
    28 Kaiser Permanente-Oakland Oakland California United States 94611
    29 Kaiser Permanente-Ontario Ontario California United States 91761
    30 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    31 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    32 Stanford Cancer Institute Palo Alto Palo Alto California United States 94304
    33 VA Palo Alto Health Care System Palo Alto California United States 94304
    34 Kaiser Permanente - Panorama City Panorama City California United States 91402
    35 Eisenhower Medical Center Rancho Mirage California United States 92270
    36 Kaiser Permanente-Riverside Riverside California United States 92505
    37 Kaiser Permanente-Roseville Roseville California United States 95661
    38 Sutter Roseville Medical Center Roseville California United States 95661
    39 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    40 Sutter Medical Center Sacramento Sacramento California United States 95816
    41 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    42 Kaiser Permanente - Sacramento Sacramento California United States 95825
    43 Kaiser Permanente-San Diego Zion San Diego California United States 92120
    44 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    45 Kaiser Permanente-San Francisco San Francisco California United States 94115
    46 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    47 Kaiser Permanente San Leandro San Leandro California United States 94577
    48 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    49 Kaiser Permanente-San Marcos San Marcos California United States 92078
    50 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    51 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    52 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    53 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    54 Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee California United States 96161
    55 Kaiser Permanente-Vallejo Vallejo California United States 94589
    56 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    57 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    58 Presbyterian Intercommunity Hospital Whittier California United States 90602
    59 Kaiser Permanente-Woodland Hills Woodland Hills California United States 91367
    60 University of Colorado Hospital Aurora Colorado United States 80045
    61 UCHealth Memorial Hospital Central Colorado Springs Colorado United States 80909
    62 Memorial Hospital North Colorado Springs Colorado United States 80920
    63 Poudre Valley Hospital Fort Collins Colorado United States 80524
    64 Cancer Care and Hematology-Fort Collins Fort Collins Colorado United States 80528
    65 UCHealth Greeley Hospital Greeley Colorado United States 80631
    66 Medical Center of the Rockies Loveland Colorado United States 80538
    67 Hartford Hospital Hartford Connecticut United States 06102
    68 Midstate Medical Center Meriden Connecticut United States 06451
    69 The Hospital of Central Connecticut New Britain Connecticut United States 06050
    70 Yale University New Haven Connecticut United States 06520
    71 Eastern Connecticut Hematology and Oncology Associates Norwich Connecticut United States 06360
    72 MedStar Washington Hospital Center Washington District of Columbia United States 20010
    73 Sibley Memorial Hospital Washington District of Columbia United States 20016
    74 George Washington University Medical Center Washington District of Columbia United States 20037
    75 UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida United States 33146
    76 UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida United States 33442
    77 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    78 University of Florida Health Science Center - Gainesville Gainesville Florida United States 32610
    79 Baptist MD Anderson Cancer Center Jacksonville Florida United States 32207
    80 Lakeland Regional Health Hollis Cancer Center Lakeland Florida United States 33805
    81 The Watson Clinic Lakeland Florida United States 33805
    82 University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida United States 33136
    83 Miami Cancer Institute Miami Florida United States 33176
    84 UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida United States 33176
    85 UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida United States 33324
    86 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    87 Atlanta VA Medical Center Decatur Georgia United States 30033
    88 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    89 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    90 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    91 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    92 Queen's Medical Center Honolulu Hawaii United States 96813
    93 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    94 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    95 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    96 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    97 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    98 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    99 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    100 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    101 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    102 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    103 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    104 Illinois CancerCare-Canton Canton Illinois United States 61520
    105 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    106 Northwestern University Chicago Illinois United States 60611
    107 Rush University Medical Center Chicago Illinois United States 60612
    108 University of Illinois Chicago Illinois United States 60612
    109 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    110 Carle on Vermilion Danville Illinois United States 61832
    111 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    112 Carle Physician Group-Effingham Effingham Illinois United States 62401
    113 Crossroads Cancer Center Effingham Illinois United States 62401
    114 Elmhurst Memorial Hospital Elmhurst Illinois United States 60126
    115 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    116 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    117 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    118 Edward Hines Jr VA Hospital Hines Illinois United States 60141
    119 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    120 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    121 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    122 Loyola University Medical Center Maywood Illinois United States 60153
    123 Edward Hospital/Cancer Center Naperville Illinois United States 60540
    124 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    125 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    126 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    127 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    128 Illinois CancerCare-Peru Peru Illinois United States 61354
    129 Edward Hospital/Cancer Center?Plainfield Plainfield Illinois United States 60585
    130 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    131 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    132 Springfield Clinic Springfield Illinois United States 62702
    133 Carle Cancer Center Urbana Illinois United States 61801
    134 The Carle Foundation Hospital Urbana Illinois United States 61801
    135 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    136 Parkview Regional Medical Center Fort Wayne Indiana United States 46845
    137 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    138 Sidney and Lois Eskenazi Hospital Indianapolis Indiana United States 46202
    139 Franciscan Health Indianapolis Indianapolis Indiana United States 46237
    140 Woodland Cancer Care Center Michigan City Indiana United States 46360
    141 Franciscan Health Mooresville Mooresville Indiana United States 46158
    142 Reid Health Richmond Indiana United States 47374
    143 Memorial Hospital of South Bend South Bend Indiana United States 46601
    144 Mary Greeley Medical Center Ames Iowa United States 50010
    145 McFarland Clinic PC - Ames Ames Iowa United States 50010
    146 McFarland Clinic PC-Boone Boone Iowa United States 50036
    147 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    148 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    149 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    150 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    151 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    152 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    153 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    154 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    155 HaysMed University of Kansas Health System Hays Kansas United States 67601
    156 University of Kansas Cancer Center Kansas City Kansas United States 66160
    157 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    158 Olathe Health Cancer Center Olathe Kansas United States 66061
    159 University of Kansas Cancer Center-Overland Park Overland Park Kansas United States 66210
    160 Ascension Via Christi - Pittsburg Pittsburg Kansas United States 66762
    161 Salina Regional Health Center Salina Kansas United States 67401
    162 Cotton O'Neil Cancer Center / Stormont Vail Health Topeka Kansas United States 66606
    163 University of Kansas Health System Saint Francis Campus Topeka Kansas United States 66606
    164 University of Kansas Hospital-Westwood Cancer Center Westwood Kansas United States 66205
    165 University of Kentucky/Markey Cancer Center Lexington Kentucky United States 40536
    166 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    167 Louisiana Hematology Oncology Associates LLC Baton Rouge Louisiana United States 70809
    168 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    169 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    170 Northshore Oncology Associates-Covington Covington Louisiana United States 70433
    171 Oncology Center of The South Incorporated Houma Louisiana United States 70360
    172 East Jefferson General Hospital Metairie Louisiana United States 70006
    173 LSU Healthcare Network / Metairie Multi-Specialty Clinic Metairie Louisiana United States 70006
    174 Louisiana State University Health Science Center New Orleans Louisiana United States 70112
    175 Tulane University Health Sciences Center New Orleans Louisiana United States 70112
    176 University Medical Center New Orleans New Orleans Louisiana United States 70112
    177 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    178 LSU Health Sciences Center at Shreveport Shreveport Louisiana United States 71103
    179 Harold Alfond Center for Cancer Care Augusta Maine United States 04330
    180 Eastern Maine Medical Center Bangor Maine United States 04401
    181 Waldo County General Hospital Belfast Maine United States 04915
    182 MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford Biddeford Maine United States 04005
    183 Lafayette Family Cancer Center-EMMC Brewer Maine United States 04412
    184 Penobscot Bay Medical Center Rockport Maine United States 04856
    185 MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford Sanford Maine United States 04073
    186 Maine Medical Partners - South Portland South Portland Maine United States 04106
    187 Greater Baltimore Medical Center Baltimore Maryland United States 21204
    188 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland United States 21287
    189 Beverly Hospital Beverly Massachusetts United States 01915
    190 Massachusetts General Hospital Cancer Center Boston Massachusetts United States 02114
    191 Brigham and Women's Hospital Boston Massachusetts United States 02115
    192 Boston Medical Center Boston Massachusetts United States 02118
    193 Beth Israel Deaconess Medical Center Boston Massachusetts United States 02215
    194 Dana-Farber Cancer Institute Boston Massachusetts United States 02215
    195 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    196 Simonds-Sinon Regional Cancer Center Fitchburg Massachusetts United States 01420
    197 Winchester Hospital Winchester Massachusetts United States 01890
    198 UMass Memorial Medical Center - University Campus Worcester Massachusetts United States 01655
    199 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    200 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    201 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    202 Saint Joseph Mercy Canton Canton Michigan United States 48188
    203 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    204 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    205 Henry Ford Hospital Detroit Michigan United States 48202
    206 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    207 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    208 Sparrow Hospital Lansing Michigan United States 48912
    209 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    210 William Beaumont Hospital-Royal Oak Royal Oak Michigan United States 48073
    211 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    212 William Beaumont Hospital - Troy Troy Michigan United States 48085
    213 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    214 Minneapolis VA Medical Center Minneapolis Minnesota United States 55417
    215 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    216 Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota United States 56303
    217 Gulfport Memorial Hospital Gulfport Mississippi United States 39502
    218 University of Mississippi Medical Center Jackson Mississippi United States 39216
    219 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    220 Saint Luke's Hospital Chesterfield Missouri United States 63017
    221 University of Missouri - Ellis Fischel Columbia Missouri United States 65212
    222 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    223 Truman Medical Centers Kansas City Missouri United States 64108
    224 University of Kansas Cancer Center - North Kansas City Missouri United States 64154
    225 University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri United States 64064
    226 Washington University School of Medicine Saint Louis Missouri United States 63110
    227 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    228 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    229 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    230 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    231 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    232 CHI Health Saint Francis Grand Island Nebraska United States 68803
    233 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    234 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    235 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    236 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    237 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    238 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    239 University Cancer Center Las Vegas Nevada United States 89169
    240 Renown Regional Medical Center Reno Nevada United States 89502
    241 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    242 Englewood Hospital and Medical Center Englewood New Jersey United States 07631
    243 Hackensack University Medical Center Hackensack New Jersey United States 07601
    244 Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick New Jersey United States 08903
    245 Rutgers Cancer Institute of New Jersey New Brunswick New Jersey United States 08903
    246 Robert Wood Johnson University Hospital Somerset Somerville New Jersey United States 08876
    247 Albany Medical Center Albany New York United States 12208
    248 Montefiore Medical Center-Einstein Campus Bronx New York United States 10461
    249 Montefiore Medical Center-Weiler Hospital Bronx New York United States 10461
    250 Montefiore Medical Center - Moses Campus Bronx New York United States 10467
    251 James J Peters VA Medical Center Bronx New York United States 10468
    252 Glens Falls Hospital Glens Falls New York United States 12801
    253 Northwell Health/Center for Advanced Medicine Lake Success New York United States 11042
    254 Long Island Jewish Medical Center New Hyde Park New York United States 11040
    255 Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York United States 10016
    256 NYP/Weill Cornell Medical Center New York New York United States 10065
    257 University of Rochester Rochester New York United States 14642
    258 State University of New York Upstate Medical University Syracuse New York United States 13210
    259 Dickstein Cancer Treatment Center White Plains New York United States 10601
    260 Rex Hematology Oncology Associates-Cary Cary North Carolina United States 27518
    261 UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina United States 27599
    262 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    263 Duke University Medical Center Durham North Carolina United States 27710
    264 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    265 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    266 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    267 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    268 Vidant Oncology-Kenansville Kenansville North Carolina United States 28349
    269 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    270 Rex Hematology Oncology Associates-Blue Ridge Raleigh North Carolina United States 27607
    271 UNC Rex Cancer Center Raleigh North Carolina United States 27607
    272 Rex Cancer Center of Wakefield Raleigh North Carolina United States 27614
    273 Vidant Oncology-Richlands Richlands North Carolina United States 28574
    274 Novant Health Forsyth Medical Center Winston-Salem North Carolina United States 27103
    275 Wake Forest University Health Sciences Winston-Salem North Carolina United States 27157
    276 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    277 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    278 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    279 Summa Health System - Akron Campus Akron Ohio United States 44304
    280 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    281 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    282 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    283 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    284 Bethesda North Hospital Cincinnati Ohio United States 45242
    285 Case Western Reserve University Cleveland Ohio United States 44106
    286 MetroHealth Medical Center Cleveland Ohio United States 44109
    287 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    288 Kettering Medical Center Kettering Ohio United States 45429
    289 UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio United States 44130
    290 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    291 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    292 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    293 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    294 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    295 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    296 Rogue Valley Medical Center Medford Oregon United States 97504
    297 Providence Newberg Medical Center Newberg Oregon United States 97132
    298 Providence Willamette Falls Medical Center Oregon City Oregon United States 97045
    299 Providence Portland Medical Center Portland Oregon United States 97213
    300 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    301 Kaiser Permanente Northwest Portland Oregon United States 97227
    302 Oregon Health and Science University Portland Oregon United States 97239
    303 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    304 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    305 Geisinger Medical Center Danville Pennsylvania United States 17822
    306 Penn State Milton S Hershey Medical Center Hershey Pennsylvania United States 17033-0850
    307 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    308 Fox Chase Cancer Center Philadelphia Pennsylvania United States 19111
    309 Temple University Hospital Philadelphia Pennsylvania United States 19140
    310 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    311 Reading Hospital West Reading Pennsylvania United States 19611
    312 UPMC Susquehanna Williamsport Pennsylvania United States 17701
    313 Rhode Island Hospital Providence Rhode Island United States 02903
    314 Miriam Hospital Providence Rhode Island United States 02906
    315 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    316 Ralph H Johnson VA Medical Center Charleston South Carolina United States 29401
    317 Medical University of South Carolina Charleston South Carolina United States 29425
    318 Prisma Health Cancer Institute - Laurens Clinton South Carolina United States 29325
    319 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    320 Gibbs Cancer Center-Gaffney Gaffney South Carolina United States 29341
    321 Saint Francis Hospital Greenville South Carolina United States 29601
    322 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    323 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    324 Saint Francis Cancer Center Greenville South Carolina United States 29607
    325 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    326 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    327 Gibbs Cancer Center-Pelham Greer South Carolina United States 29651
    328 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    329 Spartanburg Medical Center Spartanburg South Carolina United States 29303
    330 Lexington Medical Center West Columbia South Carolina United States 29169
    331 Meharry Medical College Nashville Tennessee United States 37208
    332 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    333 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    334 UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas United States 76104
    335 University of Texas Medical Branch Galveston Texas United States 77555-0565
    336 Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas United States 77030
    337 Ben Taub General Hospital Houston Texas United States 77030
    338 UTMB Cancer Center at Victory Lakes League City Texas United States 77573
    339 UT Southwestern Clinical Center at Richardson/Plano Richardson Texas United States 75080
    340 Audie L Murphy VA Hospital San Antonio Texas United States 78229
    341 University of Texas Health Science Center at San Antonio San Antonio Texas United States 78229
    342 Farmington Health Center Farmington Utah United States 84025
    343 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    344 South Jordan Health Center South Jordan Utah United States 84009
    345 Central Vermont Medical Center/National Life Cancer Treatment Berlin Vermont United States 05602
    346 University of Vermont Medical Center Burlington Vermont United States 05401
    347 University of Vermont and State Agricultural College Burlington Vermont United States 05405
    348 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    349 Sovah Health Martinsville Martinsville Virginia United States 24115
    350 Bon Secours Memorial Regional Medical Center Mechanicsville Virginia United States 23116
    351 Bon Secours Saint Francis Medical Center Midlothian Virginia United States 23114
    352 Bon Secours Saint Mary's Hospital Richmond Virginia United States 23226
    353 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    354 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    355 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    356 Fred Hutchinson Cancer Research Center Seattle Washington United States 98109
    357 Seattle Cancer Care Alliance Seattle Washington United States 98109
    358 University of Washington Medical Center - Montlake Seattle Washington United States 98195
    359 Langlade Hospital and Cancer Center Antigo Wisconsin United States 54409
    360 ThedaCare Regional Cancer Center Appleton Wisconsin United States 54911
    361 Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield Wisconsin United States 53045
    362 Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin United States 53105
    363 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    364 Aurora Health Center-Fond du Lac Fond Du Lac Wisconsin United States 54937
    365 Ascension Saint Francis - Reiman Cancer Center Franklin Wisconsin United States 53132
    366 Aurora Health Care Germantown Health Center Germantown Wisconsin United States 53022
    367 Aurora Cancer Care-Grafton Grafton Wisconsin United States 53024
    368 Aurora BayCare Medical Center Green Bay Wisconsin United States 54311
    369 UW Cancer Center Johnson Creek Johnson Creek Wisconsin United States 53038
    370 Aurora Cancer Care-Kenosha South Kenosha Wisconsin United States 53142
    371 William S Middleton VA Medical Center Madison Wisconsin United States 53705
    372 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    373 Aurora Bay Area Medical Group-Marinette Marinette Wisconsin United States 54143
    374 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    375 Aspirus Medford Hospital Medford Wisconsin United States 54451
    376 Aurora Cancer Care-Milwaukee Milwaukee Wisconsin United States 53209
    377 Aurora Saint Luke's Medical Center Milwaukee Wisconsin United States 53215
    378 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    379 Aurora Sinai Medical Center Milwaukee Wisconsin United States 53233
    380 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    381 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    382 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    383 Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin United States 54904
    384 Aurora Cancer Care-Racine Racine Wisconsin United States 53406
    385 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    386 Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin United States 53081
    387 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    388 Aurora Medical Center in Summit Summit Wisconsin United States 53066
    389 Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin United States 54241
    390 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    391 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    392 Aspirus Regional Cancer Center Wausau Wisconsin United States 54401
    393 Marshfield Clinic-Wausau Center Wausau Wisconsin United States 54401
    394 Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa Wisconsin United States 53226
    395 Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin United States 53226
    396 Aurora West Allis Medical Center West Allis Wisconsin United States 53227
    397 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    398 Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin United States 54494
    399 Tom Baker Cancer Centre Calgary Alberta Canada T2N 4N2
    400 Cross Cancer Institute Edmonton Alberta Canada T6G 1Z2
    401 CancerCare Manitoba Winnipeg Manitoba Canada R3E 0V9
    402 The Moncton Hospital Moncton New Brunswick Canada E1C 6Z8
    403 QEII Health Sciences Centre/Nova Scotia Health Authority Halifax Nova Scotia Canada B3H 2Y9
    404 Saint Joseph's Healthcare Charlton Campus Hamilton Ontario Canada L8N 4A6
    405 Juravinski Cancer Centre at Hamilton Health Sciences Hamilton Ontario Canada L8V 5C2
    406 Kingston Health Sciences Centre Kingston Ontario Canada K7L 2V7
    407 London Regional Cancer Program London Ontario Canada N6A 4L6
    408 Niagara Health System-Saint Catharines General Saint Catharines Ontario Canada L2S 0A9
    409 Odette Cancer Centre- Sunnybrook Health Sciences Centre Toronto Ontario Canada M4N 3M5
    410 University Health Network-Princess Margaret Hospital Toronto Ontario Canada M5G 2M9
    411 Windsor Regional Cancer Centre Windsor Ontario Canada N8W 2X3
    412 CHUM - Centre Hospitalier de l'Universite de Montreal Montreal Quebec Canada H2X 3E4
    413 Centre Hospitalier Universitaire de Sherbrooke-Fleurimont Sherbrooke Quebec Canada J1H 5N4
    414 Rambam Medical Center Haifa Israel 31096
    415 Shaare Zedek Medical Center Jerusalem Israel 91031

    Sponsors and Collaborators

    • National Cancer Institute (NCI)
    • Canadian Cancer Trials Group

    Investigators

    • Principal Investigator: Lauren Harshman, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03055013
    Other Study ID Numbers:
    • NCI-2016-00326
    • NCI-2016-00326
    • EA8143
    • EA8143
    • EA8143
    • U10CA180820
    First Posted:
    Feb 16, 2017
    Last Update Posted:
    Jul 28, 2022
    Last Verified:
    May 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Carcinoma
    Carcinoma, Renal Cell
    Nivolumab

    Study Results

    No Results Posted as of Jul 28, 2022