Methylation Effects of COV-19 Infection and Vaccinations
Study Details
Study Description
Brief Summary
This is a retrospective non-randomized clinical study of 60 patients total to assess the effects of SARS-CoV-2 infection and the SARS-CoV-2 vaccination. This study will have 2 arms evaluating the epigenomes of patients pre and post-exposure to one of the interventions. The first arm of the study will analyze 40 patients' epigenomes whose DNA methylation was examined pre and post SARS-CoV-2 infection. The second arm of this study is analyzing 20 patients' epigenomes whose DNA methylation was examined pre and post-injection of the SARS-CoV-2 vaccine.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients infected with SARS-CoV-2 The first part of this study looks at the methylation patterns in individuals who have a baseline test taken of their DNA methylation patterns in their epigenome and then a follow-up test after they contracted SARS-CoV-2 |
|
| Patients who have received an mRNA vaccination The second part of the study looks at the methylation patterns in individuals who have a baseline test taken of their DNA methylation patterns in their epigenome and then a follow-up test after SARS CoV-2 mRNA vaccine injection. |
Biological: SARS-CoV-2 mRNA vaccine
mRNA vaccine for COVID
|
Outcome Measures
Primary Outcome Measures
- Methylation age clock testing [Change from baseline after COVID-19 infection]
The DNA clocks that will be used to precisely measure aging is TruAge Biological Age test, which estimates biological age vs. chronological age
- Methylation age clock testing [Change from baseline after COVID-19 mRNA vaccination]
The DNA clocks that will be used to precisely measure aging is TruAge Biological Age test, which estimates biological age vs. chronological age
Secondary Outcome Measures
- Overall state of health [Change from baseline after COVID-19 infection]
Questionnaire assessing overall health
- Overall state of health [Change from baseline after COVID-19 mRNA vaccination]
Questionnaire assessing overall health
Eligibility Criteria
Criteria
Inclusion Criteria:
- Subjects that are healthy individuals and of any sex, ethnicity, and anyone above the age of 18 years old.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | TruDiagnostic | Lexington | Kentucky | United States | 40503 |
Sponsors and Collaborators
- TruDiagnostic
- Cornell University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Bonek K, Roszkowski L, Massalska M, Maslinski W, Ciechomska M. Biologic Drugs for Rheumatoid Arthritis in the Context of Biosimilars, Genetics, Epigenetics and COVID-19 Treatment. Cells. 2021 Feb 4;10(2). pii: 323. doi: 10.3390/cells10020323. Review.
- Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020 May;20(5):269-270. doi: 10.1038/s41577-020-0308-3.
- Corey L, Mascola JR, Fauci AS, Collins FS. A strategic approach to COVID-19 vaccine R&D. Science. 2020 May 29;368(6494):948-950. doi: 10.1126/science.abc5312. Epub 2020 May 11.
- TD-ME-001