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MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASE

Sponsor
Cukurova University (Other)
Overall Status
Completed
CT.gov ID
NCT01780363
Collaborator
(none)
2
Locations

Study Details

Study Description

Brief Summary

Background: Genetics is suggested to play a critical role in the development of Behçet's disease (BD). Shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly from mevalonate kinase deficiency related diseases. We planned to study for evaluating the frequency of mutations and their clinical significance in mevalonate kinase gene in Turkish patients with Behçet's disease.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Study Start Date :
    Jan 1, 2011
    Actual Primary Completion Date :
    Dec 1, 2011

    Arms and Interventions

    Arm Intervention/Treatment
    controls

    frequency of mevalonate kinase gene frequency
    Behçet patients

    frequency of mevalonate kinase gene mutations

    Outcome Measures

    Primary Outcome Measures

    1. Frequency of mevalonate kinase frequency in Behçet disease [One year]

    Secondary Outcome Measures

    1. Mevalonate kinase gene and clinical correlations in Behçet's disease [One year]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Behçet patients
    Exclusion Criteria:
    • Diagnosis of periodic fever syndromes

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Cukurova University Adana Turkey 01330
    2 Didem Arslan Tas Adana Turkey 01330

    Sponsors and Collaborators

    • Cukurova University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Didem Arslan Tas, MD, Cukurova University
    ClinicalTrials.gov Identifier:
    NCT01780363
    Other Study ID Numbers:
    • BH-MVK
    • CUTFBAP25011138
    • CUTFBAP2501201138
    First Posted:
    Jan 31, 2013
    Last Update Posted:
    Jan 31, 2013
    Last Verified:
    Jan 1, 2011
    Additional relevant MeSH terms:
    Behcet Syndrome

    Study Results

    No Results Posted as of Jan 31, 2013