MSI-CRC: Microsatellite Instability in Colorectal Cancers
Study Details
Study Description
Brief Summary
In this study, we aimed to identify the different histopathological features of tumors with microsatellite instability (MSI) compared to microsatellite stable (MSS) in patients who underwent surgery for colorectal cancer. We also planned to determine how MSI affects prognostic parameters.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
According to Global Cancer Statistics, higher than 1.9 million new cases of colorectal cancer (CRC) and 935,000 deaths are estimated to occur in 2020, representing about one in 10 cancer cases and deaths. Overall, it ranks third in colorectal incidence but second in mortality.
In CRC evolution, the acquisition of genomic instability is a critical point, and there are at least two different pathways in the pathogenesis of CRC: the chromosomal instability (CIN) pathway (85%) and the microsatellite instability (MSI) pathway (15%).
Microsatellite instability (MSI) is a phenotype that occurs due to a malfunction in the DNA repair mechanism and is seen in approximately 15% of colorectal cancers (CRCs). CRCs with MSI have different clinical features, such as a tendency to settle in the proximal colon, poor differentiation, and more lymphocytic infiltration in the tumor. It has been shown that CRCs with MSI have a better prognosis and respond differently to chemotherapy than CRCs with microsatellite stable (MSS).
We aimed to evaluate the different histopathological features of tumors with MSI compared to MSS in patients who underwent surgery for colorectal cancer. We also planned to determine how MSI affects prognostic parameters such as mortality rate, recurrence, disease-free survival, cancer-specific survival, and overall survival.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Microsatellite instability Immunohistochemical analysis was performed for Microsatellite Instability (MSI) status of colorectal tumors tissue. |
Diagnostic Test: Microsatellite instability analysis
Molecular analysis for Microsatellite Instability (MSI) status was performed using immunohistochemistry (IHC). IHC now recognized as an approved method to highly precision predict MSI in colorectal cancer.
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Outcome Measures
Primary Outcome Measures
- Overall Survival [Five years]
Overall survival is defined as the time interval from the time of primary operation to the date of all-cause death or the last follow-up.
- Disease-Free Survival [Five years]
Disease-Free Survival is defined as the time interval from the time of primary operation to disease recurrence or death.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Colorectal surgery patients
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Complete follow-up information
Exclusion Criteria:
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Whose MSI status was not studied in the pathology material
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Missing follow-up information
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Colorectal resection for non-neoplastic diseases
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sultan 2. Abdulhamid Training and Research Hospital | Istanbul | Turkey | 34668 |
Sponsors and Collaborators
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Investigators
- Principal Investigator: Taygun Gülşen, MD, Sultan 2. Abdulhamid Training and Research Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010 Jun;138(6):2073-2087.e3. doi: 10.1053/j.gastro.2009.12.064. Review.
- Gupta R, Sinha S, Paul RN. The impact of microsatellite stability status in colorectal cancer. Curr Probl Cancer. 2018 Nov;42(6):548-559. doi: 10.1016/j.currproblcancer.2018.06.010. Epub 2018 Jul 18. Review.
- Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
- s2021.crc