EURO-ccraft: EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
Study Details
Study Description
Brief Summary
Rationale: coronary microvascular disease is a relatively 'new' entity within the field of cardiology. The investigators are able to investigate the microcirculation by measurements performed in the catheterization laboratory. But even though measurements are performed on a daily basis, a lot of questions regarding microvascular disease remain. The rationale of this registry is to get an overview of patients and measurement values in daily routine practice.
Objective and main endpoint: No previous registries have been set-up where coronary blood flow and resistance was systematically stored. Therefore the analyses will be mainly descriptive. The objective is to acquire a better insight in the indications and use of this technique in everyday practice , its consequences for clinical decision making, and to enable interventionalists to exchange mutual knowledge about this specific methodology and about the coronary microcirculation in general.
Study design: prospective registry
Study population: All patients who underwent coronary angiography with or without coronary intervention for any reason and if an indication for the foreseen intracoronary physiologic measurements is present according to the discretion of the operator.
Intervention (if applicable): none, only usage of measurement data. The only 'intervention' for all patients is a questionnaire.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
This registry only collects all measurement data from normal/routine physiologic assessment in the cathlab. These measurements are performed on a daily basis. The following paragraph will explain these routine measurements briefly.
Short description of the procedure Coronary angiography, PCI (if indicated), and physiologic measurements are performed completely according to normal routine. Physiologic measurements may include FFR, NHPR, IMR, CFR, absolute flow (Q) and microcirculatory resistance (Rmicro or MRR) measurement.
Intention to measure Q and Rmicro are mandatory to be included in this registry.
If there is failure to measure Q and/or Rmicro , it should be carefully noted including the reason for failure.
Coronary physiologic measurements may be performed either prior or after PCI, if applicable. If they are performed before PCI, it is recommended (according to Good Clinical Practice) but not absolutely mandatory to repeat these measurements also after PCI.
As said, the invasive procedure itself, including all measurements, should be performed completely according to clinical routine. Use of drugs either during or after the procedure should also exactly identical to normal routine.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| patients undergoing invasive assessment of the microcirculation All patients are eligible for participation in this registry if they are undergoing coronary angiography with or without coronary intervention for any reason and if an indication for the foreseen intracoronary physiologic measurements is present according to the discretion of the investigating operator. There are no specific exclusion criteria other than contraindications for physiologic measurements in general. |
Diagnostic Test: absolute flow and resistance measurements
This registry only collects all measurement data from normal/routine physiologic assessment in the cathlab. These measurements are performed on a daily basis
Short description of the procedure Coronary angiography, PCI (if indicated), and physiologic measurements are performed completely according to normal routine. Physiologic measurements may include FFR, NHPR, IMR, CFR, absolute flow (Q) and microcirculatory resistance (Rmicro or MRR) measurement.
Intention to measure Q and Rmicro are mandatory to be included in this registry.
Use of drugs either during or after the procedure should also exactly identical to normal routine.
|
Outcome Measures
Primary Outcome Measures
- clinical treatment assessment [1 year]
change in clinical decision making after invasive assessment of the microcirculation
Secondary Outcome Measures
- IMR and resistance measurement [2 years]
comparison between IMR and microvascular R measurements in WU
Eligibility Criteria
Criteria
Inclusion criteria:
-
All patients are eligible for participation in this registry if they are undergoing coronary angiography with or without coronary intervention for any reason and if an indication for the foreseen intracoronary physiologic measurements is present according to the discretion of the investigating operator.
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18 and <90 years of age
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able to give informed consent
Exclusion criteria:
- There are no specific exclusion criteria other than contraindications for physiologic measurements in general.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Catharina Hospital | Eindhoven | Brabant | Netherlands | 5623EJ |
Sponsors and Collaborators
- Catharina Ziekenhuis Eindhoven
- Onze Lieve Vrouwziekenhuis Aalst
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NL74650.100.20