Prochlorperazine Versus Prochlorperazine & Ketorolac in Treatment of Pediatric Migraine in the Emergency Department
Study Details
Study Description
Brief Summary
The aim of this study is to evaluate whether the use of prochlorperazine and ketorolac in combination lead in a larger reduction in pain score compared to prochlorperazine alone when treating pediatric migraine in the Emergency Department (ED). Our hypothesis is that this combination of medications treats not only the pain but also the associated gastrointestinal symptoms of migraine. The main outcome of this study is the reduction in the patient's pain score at 60 minutes from administration of the study medications. Secondary outcomes include the number of patients achieving complete resolution of the headache while in the ED, the number of patients requiring additional treatment interventions by the treating physician, the number of patients with resolution of the associated symptoms like nausea, vomiting, photophobia and phonophobia, the recurrence of headache in the 48-72 hours after discharge, and side effects of the medications.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 4 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: ketorolac
|
Drug: Ketorolac
Ketorolac(0.5mg/kg) IV push
|
| Placebo Comparator: Placebo Placebo IV push |
Drug: Placebo
Sodium Chloride 0.9% - 10 mL IV push
|
Outcome Measures
Primary Outcome Measures
- Reduction in the patient's pain score at 60 minutes from administration of the study medications [60 minutes from administration of the study medications]
Secondary Outcome Measures
- number of patients achieving complete resolution of the headache while in the emergency department. [while in the emergency department, an expected average of 2 hours.]
- number of patients requiring additional treatment interventions by the treating physician [while in the emergency department, an expected average of 2 hours.]
- number of patients with resolution of the associated symptoms like nausea, vomiting, photophobia and phonophobia [while in the emergency department, an expected average of 2 hours.]
- recurrence of headache [48-72 hours after discharge]
- side effects of medications [48-72 hours after discharge]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
patient aged 8-18 years presenting to Akron Children's Hospital (ACH) ED with complaint of headache
-
patient has an established diagnosis of migraine without aura or as established by history meets the criteria for migraine headache as defined by the International Criteria for Headache Disorder -II in 2004 a. At least 5 episodes of headache b. The headache should last between 1-72 hours c. The headache should include two of the following: i. Unilateral location, though may be bifrontal or frontotemporal in location but should not be occipital ii. Pulsing quality iii. Moderate to severe pain
- Aggravation by or causing avoidance of routine physical activity d. One of the following symptoms should accompany the headache i. Nausea or vomiting ii. Photophobia or phonophobia e. The headache should not be attributed to another disorder based on history, physical and/or laboratory information.
Exclusion Criteria:
-
Patients with a contraindication to receiving prochlorperazine, ketorolac, diphenhydramine, or naproxen
-
Patients unable to complete the pain scale.
-
Patients on medications that will have a drug-drug interaction with the study medication including prochlorperazine, ketorolac, diphenhydramine or naproxen.
-
Patients with any medical condition that may be contributing or associated with the current headache such as concussion or trauma
-
Female patients with a positive urine HCG point of care test
-
Patients with diagnosis of or suspected to have chronic daily headaches defined as a headache lasting at least 4 hours for more than 15 days a month for the past 3 months.
-
Patients who received prochlorperazine or ketorolac in the past 48 hours.
-
Patients who had previously been randomized in this study in the past 3 months.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Akron Children's Hospital | Akron | Ohio | United States | 44308 |
Sponsors and Collaborators
- Akron Children's Hospital
Investigators
- Principal Investigator: sarah Kline-Krammes, MD, Akron Children's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Brousseau DC, Duffy SJ, Anderson AC, Linakis JG. Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. Ann Emerg Med. 2004 Feb;43(2):256-62.
- Chambers CT, Giesbrecht K, Craig KD, Bennett SM, Huntsman E. A comparison of faces scales for the measurement of pediatric pain: children's and parents' ratings. Pain. 1999 Oct;83(1):25-35.
- Coppola M, Yealy DM, Leibold RA. Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache. Ann Emerg Med. 1995 Nov;26(5):541-6.
- Hämäläinen ML, Hoppu K, Valkeila E, Santavuori P. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. Neurology. 1997 Jan;48(1):103-7.
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- Seim MB, March JA, Dunn KA. Intravenous ketorolac vs intravenous prochlorperazine for the treatment of migraine headaches. Acad Emerg Med. 1998 Jun;5(6):573-6.
- Trottier ED, Bailey B, Dauphin-Pierre S, Gravel J. Clinical outcomes of children treated with intravenous prochlorperazine for migraine in a pediatric emergency department. J Emerg Med. 2010 Aug;39(2):166-73. doi: 10.1016/j.jemermed.2008.08.012. Epub 2009 Jan 15.
- Trottier ED, Bailey B, Lucas N, Lortie A. Prochlorperazine in children with migraine: a look at its effectiveness and rate of akathisia. Am J Emerg Med. 2012 Mar;30(3):456-63. doi: 10.1016/j.ajem.2010.12.020. Epub 2011 Feb 5.
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