Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura

Sponsor

Danish Headache Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT00877838

Collaborator

NeurAxon Inc. (Industry)

Enrollment

Location

Duration (Months)

2.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The following study is being conducted to explore the safety and effectiveness of a new chemical entity called NXN-188 in subjects with a history of migraine with aura. In this study subjects will treat two attacks of migraine with aura during the aura phase - once with placebo and once with NXN-188.

Condition or Disease	Intervention/Treatment	Phase
Migraine With Aura	Drug: NXN-188 Drug: Placebo	Phase 2

Detailed Description

The purpose of this study is to examine a new chemical entity with 5HT agonist activity and an inhibition of the nitric oxide synthase enzyme (NOS) in patients suffering from migraine with aura. Nitric oxide has diverse roles both in normal and pathological processes including the regulation of blood pressure, neurotransmission, and macrophage defense systems. NO is synthesized by three isoforms of the NOS enzyme: neuronal (n), inducible (i) and endothelial (e). Neuronal NOS (nNOS) is found mainly in neuronal tissue and regulates changes in response sensitivity and cellular plasticity; iNOS is found in macrophages and other tissue, produces NO in response to stress and injury and is one source of inflammation; eNOS is found in endothelial cells, responsible for vascular homeostasis and the presumed mechanism for the effects of nitroglycerine therapy in angina; nitroglycerine is an NO donor. NXN-188 is selectively inhibits nNOS.

There is ample scientific and clinical evidence that NO is involved in the pathogenesis of migraine pain, as well as other pain states characterized by central sensitization (e.g., neuropathic pain). NO donors such as trinitroglycerine induce headache followed by migraine in migraineurs with or without aura ; moreover, platelet nitrates (a signal for increased NO) increase before and during a migraine attack. In addition, increasing NO levels can enhance pain responses in animals, including allodynia in rats; NO is a component of several pathways where pain systems converge in the PNS and CNS and regulates the activity of numerous transmitter systems ; NO is involved in central sensitization particularly those involving NMDA and calcium channels and thought to be a major component of the formation of neuropathic pain states Non-specific NOS inhibitors have been reported to relieve migraine and chronic tension type headaches in human studies. In animals, NOS inhibitors reduce pain-related behaviors in multiple neuropathic pain models and spinal cord ischemia as well as reducing pain related behaviors in chemically-induced pain models, particularly in secondary pain states.

The development of central sensitization in the course of a migraine attack suggests a role for the neuronal isoform of the NOS enzyme.

NXN-188 can bind to both 5-HT1D and 5-HT1B receptors with potency similar to sumatriptan; it also selectively binds to nNOS with a level of nNOS inhibition similar to L-NMMA. NXN-188 is devoid of any relevant eNOS inhibition in in vitro cloned human enzyme assays or ex vivo in human coronary arteries and is expected to be effective in treating migraine by inhibition of the nNOS enzyme without vasoconstrictive effects associated with non-selective compounds such as L-NMMA.

The following study is being conducted to further explore NXN-188 response in subjects with a migraine history of aura. In this study subjects will treat two attacks of migraine with aura during the aura phase - once with placebo and once with NXN-188.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

40 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Triple (Participant, Care Provider, Investigator)

Primary Purpose:

Treatment

Official Title:

A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura

Study Start Date :

May 1, 2009

Anticipated Primary Completion Date :

Mar 1, 2010

Anticipated Study Completion Date :

Dec 1, 2010

Outcome Measures

Primary Outcome Measures

The severity of headache measured with a 4 point scale (The Headache Severity Score (HSS)) [2 hours after dosing]
Absence of headache [2 hours after dosing]

Secondary Outcome Measures

The occurence of any type(s) of adverse events(s) [0-48 hours after dosing]
The severity of headache measured with a 4 point scale (The Headache Severity Score (HSS)) [0, 1, 2, 4, 8 and 24 hours after dosing]
Clinical Disability measured on a 4 point scale [0, 1, 2, 4, 8 and 24 hours after dosing]
Overall evaluation of the study medication [24 hours after dosing]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Male or female migraineurs with aura between 18 and 65 years old, inclusive
Meets the following criteria for migraine headache with aura:

Diagnosed with a history of migraine with aura
Aura consisting of at least one of the following, but no muscle weakness or paralysis:
Fully reversible visual symptoms (e.g. flickering lights, spots, lines, loss of vision)
Fully reversible sensory symptoms (e.g. pins and needles, numbness)
Fully reversible dysphasia (speech disturbance)
Aura has at least two of the following characteristics:
Visual symptoms affecting just one side of the field of vision and/or sensory symptoms affecting just one side of the body
At least one aura symptom develops gradually over more than 5 minutes and/or different aura symptoms occur one after the other over more than 5 minutes
Each symptom lasts from 5-60 minutes

At least one migraine headache with aura every 8-weeks and resulting in moderate to severe pain (on a 4-point categorical scale) within 2 hours of the onset of aura.
Migraine pain following aura in at least 75% of occurrences
The subject has a body mass index (BMI) within the range of 18 to 32
The subject is in general good health as determined by the medical history, physical exam, clinical laboratory tests, vital signs [heart rate (HR) and blood pressure (BP; after a 3-minute sitting period)] and ECG

• ALT cannot be above 1.5x upper limit of normal; creatinine and urea must be within normal limits

The subject must be able to speak, read, and understand Danish sufficiently to understand the nature of the study, to provide written informed consent, and complete all study assessments
The subject is willing and able to comply with all testing requirements defined in the protocol
All females will avoid pregnancy at least 10 days before Visit 1, during the study and up until 3 months after Visit 2
Women of childbearing potential must be using a reliable form of contraception. A reliable form of contraception is defined as follows:

sterilisation (via hysterectomy or bilateral tubal ligation)
sterilisation of partner
IUD,
birth control pills on stable dose for at least three months before Visit 1, and one month after visit 2.
Medroxyprogesterone acetate (Depo-Provera) or etonogestrel (implanon) active for at least three months prior to the study and with continued administration at intervals sufficient to maintain contraceptive efficacy throughout the study period and at least one month after visit 2. Males must use condoms as contraception.

Exclusion Criteria:

Presence of any clinically significant condition that would preclude study participation, as evaluated by the investigator
Are pregnant or lactating
History of significant neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary, rheumatologic, autoimmune, or metabolic disease
Receiving any medication that, in the opinion of the Investigator or designee, may pose a risk of compromising tolerance or compliance
Are known to or suspected to be currently abusing alcohol or drugs, or have a history (within the past 12 months) of active alcohol or drug abuse
Participation in another drug or biologic study within 30 days preceding randomization into this study or during participation in this study
Subjects who are unable or unwilling, in the opinion of the Investigator, to comply with all study procedures and cooperate fully with study center staff