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A Comparative Study of Brain Structure and Amyloid Load in MCI Patients

Sponsor
Chinese University of Hong Kong (Other)
Overall Status
Withdrawn
CT.gov ID
NCT03773185
Collaborator
(none)
0
Enrollment
1
Location
19.5
Actual Duration (Months)
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Older people with DM are at greater risk of cognitive decline than their counterparts with DM. Cognitive impairment in older people with DM may be associated with non-AD related brain atrophy and white matter disease. The investigators therefore propose to compare DM and non-DM older people with amnesic MCI in brian volumes, white matter disease and amyloid load.

30 older people with aMCI, 30 older people with aMCI and DM, age 65-85 will be recruited. They all will have amyloid PET scan and MRI brain scan.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational [Patient Registry]
    Actual Enrollment :
    0 participants
    Observational Model:
    Cohort
    Time Perspective:
    Cross-Sectional
    Official Title:
    A Comparative Study of Brain Structure and Amyloid Load Between Cognitively Impaired Older People With or Without Diabetes Mellitus
    Actual Study Start Date :
    Dec 15, 2018
    Actual Primary Completion Date :
    Jul 31, 2020
    Actual Study Completion Date :
    Jul 31, 2020

    Outcome Measures

    Primary Outcome Measures

    1. Amyloid load [Two years]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    65 Years to 85 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • MCI patients
    Exclusion Criteria:
    • Patients with depression

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 The Chinese University of Hong Kong Hong Kong Hong Kong

    Sponsors and Collaborators

    • Chinese University of Hong Kong

    Investigators

    • Principal Investigator: Timothy Kwok, MD, Chinese University of Hong Kong

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Timothy Kwok, Professor, Chinese University of Hong Kong
    ClinicalTrials.gov Identifier:
    NCT03773185
    Other Study ID Numbers:
    • 2018.454
    First Posted:
    Dec 12, 2018
    Last Update Posted:
    Oct 21, 2021
    Last Verified:
    Oct 1, 2021
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Cognitive Dysfunction

    Study Results

    No Results Posted as of Oct 21, 2021