Computer-Based Therapy for Mild Cognitive Impairment

Sponsor

Posit Science Corporation (Industry)

Overall Status

Completed

CT.gov ID

NCT00319943

Collaborator

University of California, San Francisco (Other), University of California, Davis (Other), Stanford University (Other)

Enrollment

Location

21.9

Duration (Months)

2.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).

Condition or Disease	Intervention/Treatment	Phase
Mild Cognitive Impairment	Procedure: Computer-based training for Mild Cognitive Impairment (MCI)	Phase 1

Detailed Description

The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.

Study Design

Study Type:

Interventional

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double

Primary Purpose:

Treatment

Official Title:

Computer-Based Therapy for Mild Cognitive Impairment

Study Start Date :

Sep 1, 2004

Study Completion Date :

Jul 1, 2006

Outcome Measures

Primary Outcome Measures

The study investigates changes in a neuropsychological assessment battery pre-randomization []
and upon the completion of training. []

Secondary Outcome Measures

Early evaluations will be conducted from brain imaging; specifically, date []
obtained via positron emission tomography (PET), magnetoencephalography (MEG), []
electroencephalography (EEG), and functional magnetic resonance imaging (fMRI) []
studies. []

Eligibility Criteria

Criteria

Ages Eligible for Study:

65 Years to 90 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

1)65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function.

3)Fluency in English 4)Willing to meet the time commitment of the study