Can we Antagonize Mivacurium With Neostigmine ?
Study Details
Study Description
Brief Summary
The antagonism of neuromuscular blocking agents (NMBA) (or curares), as well as the antagonism of other drugs used in anesthesia, is a major challenge for the speciality.
Residual paralysis is indeed a risk factor for post-operative morbidity and mortality and antagonization of curares at the end of the procedure is associated with a reduction in mortality .
Its use should be as large as possible and its contraindications are extremely rare.
The antagonism of the NMBA reduces the duration of the neuromuscular block and the complications that are associated .
In this study, the investigators use mivacurium (or Mivacron) as non-depolarizing curare and neostigmine as an antagonist.
Neostigmine reduces the duration of the neuromuscular block induced by mivacurium, By reducing the breakdown of acetylcholine, neostigmine induces an increase in acetylcholine in the synaptic cleft which competes for the same binding site as nondepolarizing neuromuscular blocking agents, and reverses the neuromuscular blockade.
But the use of neostigmine in current practice is not very widespread in this clinical situation.
The reduction in the duration of the block is significant in comparison with a spontaneous recovery .
Moreover, spontaneous recovery is not always complete and sometimes very long.
Nevertheless, its action is effective and this study could support this use but also specify the duration and the quality of the return to normal of the neuromuscular transmission.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: GROUP 1 A group receiving neostigmine (40 mcg / kg) when the block Neuromuscular block's recovery measured by acceleromyography is 1 response of 4 in TOF mode (Train Of Four) |
Drug: Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery
|
| Active Comparator: GROUP 2 A group receiving neostigmine (40 mcg / kg) when the block Neuromuscular block's recovery measured by acceleromyography is 2 response of 4 in TOF mode (Train Of Four) |
Drug: Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery
|
| Active Comparator: GROUP 3 A group receiving neostigmine (40 mcg / kg) when the block Neuromuscular block's recovery measured by acceleromyography is 3 response of 4 in TOF mode (Train Of Four) |
Drug: Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery
|
| Active Comparator: GROUP 4 A group receiving neostigmine (40 mcg / kg) when the block Neuromuscular block's recovery measured by acceleromyography is 4 response of 4 in TOF mode (Train Of Four) |
Drug: Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery
|
| Active Comparator: CONTROL A control group : not receiving an antagonist (spontaneous recovery) |
Other: Spontaneous recovery
just measuring the Train Of Four at 3 6 9 12 and 15 minutes and measure the Train Of Four Ratio
|
Outcome Measures
Primary Outcome Measures
- Change in TOF ( Train Of Four) measure [for each patient, measure of Train Of Four at 3, 6, 9, 12, 15 minutes]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients American Society of Anesthesiologists (ASA) 1 to 3
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Absence of neuromuscular disease, renal and hepatic insufficiency
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Absence of medication that could interfere with the mediators of the neuromuscular junction
Exclusion Criteria:
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Bronchial asthma
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Parkinson disease
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BMI> 35
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Known hypersensitivity to neostigmine or to any of the excipients of Neostigmine
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Michel Baurain | Bruxelles Capitale | Belgium | 1070 |
Sponsors and Collaborators
- Université Libre de Bruxelles
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- B406201629996
- U1111-1190-7993