Molecular & Cellular Characterisation of Oral Lichen Planus
Study Details
Study Description
Brief Summary
The principal research objective is to provide enhanced understanding of the cellular and molecular events important in the pathogenesis of Oral Lichen Planus to enable improved diagnosis and development of novel treatments for patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The following questions will also be addressed:
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Are the histological architectural tissue changes that take place in oral lichen planus quantifiable using computer based imaging, graph theory and fractal geometry principles? Quantification of these changes would allow the development of a tool to facilitate the accurate measurement of response to treatment.
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What is the nature of such architectural changes and what are the differences with normal, dysplastic and neoplastic epithelia (the investigators have morphometrical data collected from previous research to allow such comparisons).
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Is it possible to produce evidence-based statistical classification into established diagnostic classes using the proposed methodology? This would contribute towards making histopathological diagnosis more quantitative, reproducible and accurate.
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Is it possible to automate such morphometrical analysis/classification? This would allow large data sets to be screened automatically in a shorter time frame and at lower cost than human based screening.
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Is it possible to determine differences in genetics and gene expression of keratinocytes involved in Oral Lichen Planus compared to those of 'normal' tissue by using biopsy material and an in vitro model of oral lichen planus?
Study Design
Outcome Measures
Primary Outcome Measures
- Histological architecture [Through study completion, (maximum 12 months from the defined end of study)]
Are the histological architectural tissue changes that take place in oral lichen planus quantifiable using computer based imaging, graph theory and fractal geometry principles?
- Comparisons with other dysplastic lesions [Through study completion, (maximum 12 months from the defined end of study)]
What is the nature of such architectural changes and what are the differences with normal, dysplastic and neoplastic epithelia
- Statistical classifications [Through study completion, (maximum 12 months from the defined end of study)]
Is it possible to produce evidence-based statistical classification into established diagnostic classes using the proposed methodology
- Automation of morphological features [Through study completion, (maximum 12 months from the defined end of study)]
Is it possible to automate such morphometrical analysis/classification?
- Molecular expression of Oral Lichen Planus markers [Through study completion, (maximum 12 months from the defined end of study)]
Is it possible to determine differences in genetics and gene expression of keratinocytes involved in Oral Lichen Planus compared to those of 'normal' tissue by using biopsy material and an in vitro model of oral lichen planus?
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patient is 16 years old or over
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Patient is willing and able to provide valid informed consent
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Patient is attending the Oral Lichen Planus clinic and will be having a routine clinical biopsy taken
Exclusion Criteria:
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Patient under 16 years old
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Patient is immunocompromised
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Patients with comorbid disease state e.g. other inflammatory disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Birmingham Dental Hospital and School of Dentistry | Birmingham | West Midlands | United Kingdom | B5 7EG |
Sponsors and Collaborators
- University of Birmingham
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RG_15-112