GeneQuest: Molecular Determinants of Coronaruy Artery Disease

Sponsor

John Barnard (Other)

Overall Status

Terminated

CT.gov ID

NCT00590291

Collaborator

National Heart, Lung, and Blood Institute (NHLBI) (NIH)

1,461

Enrollment

Location

315

Actual Duration (Months)

4.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM).

Condition or Disease	Intervention/Treatment	Phase
Coronary Artery Disease Arteriovenous Malformations Myocardial Infarction

Detailed Description

The purpose of this study is to discover genes that may cause Coronary Artery Disease (CAD) or Arteriovenous Malformation (AVM). Many human diseases are inherited or passed from parent to child in families. These diseases occur because of damage to a gene(s), the genetic material that is also called DNA. Scientists can now use modern molecular techniques to locate and to find certain genes within the DNA (genetic material) of a person, and to follow their inheritance in a family. To find these disease-causing genes requires studies of many affected with the disease and their family members. The purpose of this study is to locate and to find the genes for coronary artery disease (CAD) which occurs when one or more of the arteries that carry oxygen-rich blood from your heart to the rest of your body develop blockages; or, arteriovenous malformation (AVM) which causes abnormal vascular connections between arteries and veins, particularly near the heart. Findings of the genes causing CAD and AVM will have far-reaching effect on the diagnosis, treatment, and prevention of coronary artery disease and arteriovenous malformation. These studies will lead to possible genetic diagnosis, early detection of persons at risk for developing CAD or AVM (even in the absence of symptoms), development of effective drugs, more rational and specific therapeutic interventions, treatments and ultimately, prevention of coronary heart disease. Approximately 3-5 years are required to find one human disease gene.

Study Design

Study Type:

Observational

Actual Enrollment :

1461 participants

Observational Model:

Family-Based

Time Perspective:

Retrospective

Official Title:

Genetic Studies of Coronary Artery Disease and Arteriovenous Malformation (GeneQuest) Molecular Determinants of Coronary Artery Disease

Actual Study Start Date :

Jan 1, 1995

Actual Primary Completion Date :

Apr 1, 2021

Actual Study Completion Date :

Apr 1, 2021

Arms and Interventions

Arm	Intervention/Treatment
Cases premature CAD and MI, AVM
Controls No CAD, MI, AVM

Outcome Measures

Primary Outcome Measures

Coronary Artery Disease [2009]
Arteriovenous Malformation [2009]

Secondary Outcome Measures

Myocardial Infarction [2009]

Eligibility Criteria

Criteria

Ages Eligible for Study:

45 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Males at least 45 years old and premenopausal females at least 50 years old at the time of onset of any of the following:
PTCA
MI
CABG
Must have a living sibling meeting the same criteria.