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Molecular Epidemiology of Benzene-exposed Workers.

Sponsor
University of Colorado, Denver (Other)
Overall Status
Completed
CT.gov ID
NCT00364520
Collaborator
Fudan University (Other), University of Cincinnati (Other), ExxonMobil Biomedical Sciences, Inc. (Industry), British Petroleum P.L.C. (Industry), Chevron Corporation (Industry), ConocoPhillips (Industry), Exxon Mobil (Industry), Marathon Ashland (Other), Shell Chemicals (Industry)
2,000
Enrollment
1
Location
76
Duration (Months)
26.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to investigate the health effects of benzene exposure in workers in Shanghai, China.

Condition or Disease Intervention/Treatment Phase
  • Other: Shanghai workers

Detailed Description

The purpose of this study is to investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers and to characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Study Design

Study Type:
Observational
Actual Enrollment :
2000 participants
Observational Model:
Ecologic or Community
Time Perspective:
Cross-Sectional
Official Title:
Molecular Epidemiology of Benzene-exposed Workers in Shanghai,China
Study Start Date :
Aug 1, 2003
Actual Primary Completion Date :
Dec 1, 2009
Actual Study Completion Date :
Dec 1, 2009

Arms and Interventions

Arm Intervention/Treatment
Shanghai Workers

Shanghai Workers

Other: Shanghai workers

Outcome Measures

Primary Outcome Measures

  1. Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers. [August 2003 - December 2009]

    Investigate the dose-response relationship between benzene exposure and blood diseases in Shanghai workers

Secondary Outcome Measures

  1. Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity. [August 2003 - December 2009]

    Characterize genetic polymorphisms that are associated with increased risk of developing benzene hematotoxicity.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 67 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

Worked for at least one year in a monitored environment Have at least one physical examination recorded

-

Exclusion Criteria:

History of cancer, radiation exposure, chemotherapy

-

Contacts and Locations

Locations

Site City State Country Postal Code
1 Joint Sino-US Clinical and Molecular Laboratory (JCML) Shanghai China 200032

Sponsors and Collaborators

  • University of Colorado, Denver
  • Fudan University
  • University of Cincinnati
  • ExxonMobil Biomedical Sciences, Inc.
  • British Petroleum P.L.C.
  • Chevron Corporation
  • ConocoPhillips
  • Exxon Mobil
  • Marathon Ashland
  • Shell Chemicals

Investigators

  • Principal Investigator: Richard D Irons, PhD, University of Colorado at Denver and Health Sciences Ctr

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
University of Colorado, Denver
ClinicalTrials.gov Identifier:
NCT00364520
Other Study ID Numbers:
  • 02-0037
First Posted:
Aug 15, 2006
Last Update Posted:
May 21, 2015
Last Verified:
May 1, 2007
Keywords provided by University of Colorado, Denver
Hematologic Diseases
Benzene
Genetic Polymorphisms
Additional relevant MeSH terms:
Hematologic Diseases

Study Results

No Results Posted as of May 21, 2015