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Molecular Markers and Genetic Markers in Patients Undergoing Radiation Therapy for Cancer

Sponsor
Rutgers, The State University of New Jersey (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00899808
Collaborator
National Cancer Institute (NCI) (NIH), Rutgers Cancer Institute of New Jersey (Other)
0
Enrollment
1
Location

Study Details

Study Description

Brief Summary

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular markers and genetic markers in patients undergoing radiation therapy for cancer.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    OBJECTIVES:

    Primary

    • Determine local-regional control in patients undergoing radiation therapy for cancer, as a function of expression of specific molecular/genetic markers.

    Secondary

    • Determine complications of radiation therapy for patients undergoing radiation therapy for cancer.

    OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining and other molecular/genetic study methods to detect markers, including p53, cyclin D1, HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on local-regional relapse.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    0 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Molecular and Genetic Markers in the Local-regional Management of Patients Undergoing Radiation Therapy
    Study Start Date :
    May 1, 2006
    Actual Primary Completion Date :
    May 1, 2006

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      DISEASE CHARACTERISTICS:

      • Diagnosis of cancer

      • Undergoing radiation therapy for malignant disease

      PATIENT CHARACTERISTICS:
      • Not specified
      PRIOR CONCURRENT THERAPY:
      • See Disease Characteristics

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Rutgers Cancer Institute of New Jersey - Robert Wood Johnson Medical School New Brunswick New Jersey United States 08903

      Sponsors and Collaborators

      • Rutgers, The State University of New Jersey
      • National Cancer Institute (NCI)
      • Rutgers Cancer Institute of New Jersey

      Investigators

      • Principal Investigator: Bruce G. Haffty, MD, Rutgers Cancer Institute of New Jersey- Robert Wood Johnson Medical School

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Rutgers, The State University of New Jersey
      ClinicalTrials.gov Identifier:
      NCT00899808
      Other Study ID Numbers:
      • 000609
      • P30CA072720
      • CDR0000592887
      • CINJ-IRB-0220060141
      First Posted:
      May 12, 2009
      Last Update Posted:
      May 29, 2015
      Last Verified:
      May 1, 2015
      Keywords provided by Rutgers, The State University of New Jersey
      unspecified adult solid tumor, protocol specific
      unspecified childhood solid tumor, protocol specific
      hematopoietic/lymphoid cancer
      Additional relevant MeSH terms:
      Neoplasms

      Study Results

      No Results Posted as of May 29, 2015