Clincosm LogoSign in Get a demo

Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT00166972
Collaborator
(none)
150
Enrollment
3
Duration (Months)

Study Details

Study Description

Brief Summary

Our study established a model combine the in silico biology and empirical methods to identify clinically useful biomarker from information of microarray gene expression profiles in public domain. Through this method, we found trophinin as a novel prognostic marker for early stage lung cancer, which provide insight towards the process of cancer metastasis and the potential target for treatment.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    This study was to combine the in silico biology and empirical methods to identify clinically useful biomarker of lung cancer from microarray gene expression profiles in public database.

    Using the expression profile of a known metastasis suppressor, CRMP-1, as a template to search for and compare transcriptome expressions in publicly accessible microarray datasets, trophinin (TRO) was identified as the best correlated gene. The expression pattern of trophinin in a lung cancer cell lines of invasion model was investigated using quantitative RT-PCR. The role of trophinin in cancer metastasis was investigated by measuring the change of invasion activity in trophinin gene-transfected cell lines. The relationship of trophinin and the clinicopathological characteristics of lung cancer were further examined by immunohistochemical staining.

    Study Design

    Study Type:
    Observational
    Observational Model:
    Natural History
    Time Perspective:
    Other
    Official Title:
    Molecular Mechanism of Trophinin in Cancer Invasion and Metastasis
    Study Start Date :
    Jan 1, 2005
    Study Completion Date :
    Apr 1, 2005

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      0 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • patients who underwent surgery for non-small-cell lung cancer at the National Taiwan University Hospital from 1991 to 2000 with available stored tissue blocks were included as potential subjects in this study.
      Exclusion Criteria:

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • National Taiwan University Hospital

      Investigators

      • Principal Investigator: Kuan-Yu Chen, M.D., National Taiwan University Hospital

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00166972
      Other Study ID Numbers:
      • 9361701255
      First Posted:
      Sep 14, 2005
      Last Update Posted:
      Sep 14, 2005
      Last Verified:
      Jul 1, 2005
      Keywords provided by , ,
      metastasis, survival, malignancy, female, trophinin
      Additional relevant MeSH terms:
      Neoplasm Metastasis

      Study Results

      No Results Posted as of Sep 14, 2005