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VIN2020: Effect of Daily Vinegar Ingestion for Four Weeks on Mood State in Healthy College Students

Sponsor
Arizona State University (Other)
Overall Status
Completed
CT.gov ID
NCT04706806
Collaborator
(none)
25
Enrollment
1
Location
2
Arms
1.6
Actual Duration (Months)
15.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The objective of this research is to record mood states and depression levels in healthy college students before and after 4 weeks of daily vinegar ingestion.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: apple cider vinegar
  • Dietary Supplement: vinegar pill
 N/A

Detailed Description

Recent research suggests that fruit and vegetable intake is inversely associated with mood states and depression. Although the mechanism is not known, increased gut fermentation is suspected as changes in gut tryptophan metabolism was noted in these trials. Tryptophan is the precursor to serotonin, the neurotransmitter associated with improved mood state, but other metabolites of tryptophan have been associated with mental wellbeing as well. The main ingredient of vinegar, acetic acid, is the most common metabolite produced during gut fermentation of dietary fiber (mainly from fruits and vegetables) and can also be expected to influence the gut microbiome. It has been reported that vinegar ingestion is linked to a change in tryptophan metabolism in healthy adults consuming vinegar daily for 8 weeks. This study will explore the impact of vinegar ingestion on mood states.

Study Design

Study Type:
Interventional
Actual Enrollment :
25 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Intervention Model Description:
randomized, controlled trialrandomized, controlled trial
Masking:
Single (Participant)
Masking Description:
Both groups received vinegar, either liquid form (active) or pill form (placebo)
Primary Purpose:
Supportive Care
Official Title:
Effect of Daily Vinegar Ingestion for Four Weeks on Mood State in Healthy College Students
Actual Study Start Date :
Sep 29, 2020
Actual Primary Completion Date :
Nov 17, 2020
Actual Study Completion Date :
Nov 17, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: liquid vinegar

2 tablespoons (diluted in water) taken twice daily with meals

Dietary Supplement: apple cider vinegar
2 tablespoons diluted in water taken twice daily with meals
Other Names:
  • apple cider vinegar (Bragg Live Food Products, LLC)

    		•
    Placebo Comparator: vinegar pill

    1 vinegar pill taken daily

    Dietary Supplement: vinegar pill
    one pill taken daily
    Other Names:
  • Nature's Bounty Apple Cider Vinegar pills

    		•

    Outcome Measures

    Primary Outcome Measures

    1. mood state [change from baseline at day 28]

      Profile of Mood States (POMS) questionnaire score

    2. depression [change from baseline at day 28]

      Center for Epidemiologic Studies Depression Scale (CES-D)

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • college student, non-athlete, no chronic health condition
    Exclusion Criteria:
    • vegetarians or others adhering to special diet, body mass index >30 kg/m2, pregnancy/lactation, unwilling to ingest vinegar

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Arizona State University Phoenix Arizona United States 85004

    Sponsors and Collaborators

    • Arizona State University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Carol Johnston, Professor and Associate Dean, Arizona State University
    ClinicalTrials.gov Identifier:
    NCT04706806
    Other Study ID Numbers:
    • STUDY00012406
    First Posted:
    Jan 13, 2021
    Last Update Posted:
    Jan 13, 2021
    Last Verified:
    Jan 1, 2021
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Carol Johnston, Professor and Associate Dean, Arizona State University
    acetic acid
    Additional relevant MeSH terms:
    Depression
    Acetic Acid

    Study Results

    No Results Posted as of Jan 13, 2021