Developing and Optimizing Transcranial Magnetic Stimulation for Motor Rehabilitation
Study Details
Study Description
Brief Summary
This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Experimental: Single-pulse TMS over the primary motor cortex We will administer single-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. |
Device: Transcranial Magnetic Stimulation (TMS)
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.
|
Experimental: Paired-pulse TMS over the primary motor cortex We will administer paired-pulse TMS to the primary motor cortex while measuring motor responses and just before a skill-learning task. |
Device: Transcranial Magnetic Stimulation (TMS)
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.
|
Sham Comparator: Sham TMS over the primary motor cortex We will administer sham TMS to the primary motor cortex while measuring motor responses and before a skill-learning task. |
Device: Transcranial Magnetic Stimulation (TMS)
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.
|
Outcome Measures
Primary Outcome Measures
- Effect of TMS on motor evoked potentials [Up to 1 second after TMS]
Amplitude of the motor evoked potentials in millivolts.
- Skill learning accuracy [Up to 12 minutes]
Skill learning accuracy as the total number of correct responses.
- Skill learning speed [Up to 12 minutes]
Skill learning speed in seconds.
Eligibility Criteria
Criteria
Inclusion Criteria:
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18-40 years old
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Able to read, understand, and sign the informed consent in English
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Right-handed
Exclusion Criteria:
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A sensory or physical impairment
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History of epilepsy or seizures in the family
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Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body
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A head injury with loss of consciousness
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Diagnosis of psychiatric or neurological disorder
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Skin defects or active infections on the scalp or hands
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Pregnancy or breastfeeding
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Elisa Kallioniemi
Investigators
- Principal Investigator: Elisa Kallioniemi, Ph.D., New Jersey Institute of Technology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB_2303032088