Movement Disorders in Multiple Sclerosis Patients

Sponsor

Al-Azhar University (Other)

Overall Status

Recruiting

CT.gov ID

NCT05973929

Collaborator

(none)

Enrollment

Location

19.3

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study is to determine the prevalence of movement disorders in MS patients.

Also,To know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. Moreover, to find the correlation between the movement disorder and the different types of MS.

Condition or Disease	Intervention/Treatment	Phase
Multiple Sclerosis Movement Disorders	Other: Screen for movement disorder and correlates it with MRI findings.

Detailed Description

A randomized cross-sectional study will be conducted on diagnosed multiple sclerosis patients who were diagnosed according to McDonald criteria of MS 2017 (Thompson et al. 2018).

We will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria:

Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not).
MRI Brain and spine of the included patient will be photographed.

Exclusion criteria:

Patients with multiple sclerosis mimics which can cause movement disorders e.g., systemic disease or overlap syndromes including systemic lupus, vasculitis, hepatic failure, renal failure, hyperthyroidism, electrolyte disturbances, Behcet's disease or CNS infection.
patients with primary movement disorders or related to other neurodegenerative diseases.

Study Design

Study Type:

Observational

Anticipated Enrollment :

57 participants

Observational Model:

Case-Only

Time Perspective:

Cross-Sectional

Official Title:

Clinical and Radiological Evaluation of Movement Disorders in Multiple Sclerosis Patients.

Actual Study Start Date :

Sep 22, 2022

Anticipated Primary Completion Date :

Mar 21, 2024

Anticipated Study Completion Date :

May 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Multiple sclerosis patients with movement disorders. A randomized cross-sectional study will be conducted on diagnosed multiple sclerosis patients who were diagnosed according to McDonald criteria of MS 2017 (Thompson et al. 2018). We will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria: i. Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not). iv. MRI Brain and spine of the included patient will be photographed.	Other: Screen for movement disorder and correlates it with MRI findings. To determine the prevalence of movement disorders in MS patients. To know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. To find the correlation between the movement disorder and the different types of MS.

Arm

Intervention/Treatment

Multiple sclerosis patients with movement disorders.

A randomized cross-sectional study will be conducted on diagnosed multiple sclerosis patients who were diagnosed according to McDonald criteria of MS 2017 (Thompson et al. 2018). We will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria: i. Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not). iv. MRI Brain and spine of the included patient will be photographed.

Other: Screen for movement disorder and correlates it with MRI findings.

To determine the prevalence of movement disorders in MS patients. To know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. To find the correlation between the movement disorder and the different types of MS.

Outcome Measures

Primary Outcome Measures

Determine the prevalence of movement disorders in MS patients. [Patients over 18 months period.]
To know the percentage of occurance of movement disorders in MS patients.
know the clinical type of movement disorders occurring with multiple sclerosis patients and the MRI finding of those patients. [Patients over 18 months period.]
To know the specific semiology for each movement disorder.
find the correlation between the movement disorder and the different types of MS. [Patients over 18 months period.]
To know if there is a correlation between the movement disorder and the different types of MS.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 55 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

We will study the prevalence of movement disorders in M.S patients, clinical type of movement disorder and the MRI findings. Data collected from patients admitted or following at Al-Azhar university hospitals at Al-Hussein and El-Sayed Galal hospitals. The included eligible patients should fulfil the following inclusion criteria: i. Full clinical history and neurological assessment. ii. Detailed multiple sclerosis history according to MS unit history sheet. iii. Detailed history of movement disorder which include clinical type of movement disorder and medication taken (or not).

MRI Brain and spine of the included patient will be photographed.

Exclusion Criteria:

1-Patients with multiple sclerosis mimics which can cause movement disorders e.g., systemic disease or overlap syndromes including systemic lupus, vasculitis, hepatic failure, renal failure, hyperthyroidism, electrolyte disturbances, Behcet's disease or CNS infection.

2-patients with primary movement disorders or related to other neurodegenerative diseases.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Mostafa Mahmoud Hassan Meshref	Cairo	Select A State Or Province	Egypt	11571

Sponsors and Collaborators

Al-Azhar University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Mostafa Mahmoud Hassan Meshref, Neurology physician, Al-Azhar University

ClinicalTrials.gov Identifier:

NCT05973929

Other Study ID Numbers:

Neuro-Med._0000044

First Posted:

Aug 3, 2023

Last Update Posted:

Aug 3, 2023

Last Verified:

Jul 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Undecided

Plan to Share IPD:

Undecided

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Mostafa Mahmoud Hassan Meshref, Neurology physician, Al-Azhar University

Multiple sclerosis

Movement Disorders

Additional relevant MeSH terms:

Multiple Sclerosis

Movement Disorders

Sclerosis

Study Results

No Results Posted as of Aug 3, 2023