MR Guidance for Liver and Pancreas
Study Details
Study Description
Brief Summary
This is a single centre, single arm, prospective feasibility study that aims to see whether magnetic resonance imaging (MRI) as a source of image guidance before each radiation treatment fraction is feasible, and also if it may provide information that could potentially be used during the treatment to improve the radiation treatment plan.
Patients will have 5 MRIs with each of their RT sessions. If patients' RT treatment will consist of more than 5 fractions, only 5 MRIs will be done with any 5 RT fractions. Patients will be completing a short questionnaire at the end of each MRI. A patient questionnaire will also be completed at the end of the study to assess for patient satisfaction.
There will be 30 evaluable patients enrolled to the study.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Pancreatic Cancer Approximately 10 patients with pancreatic cancer will be enrolled to the study with the primary aim of determining the feasibility of using off-line MRI-guidance during the course of radiation treatment |
Other: MRI
Patients who consent to this study will have an abdominal MRI prior to or immediately after each fraction of radiation treatment in the case of those patients that are undergoing SBRT or those receiving palliative treatment. On patients receiving definitive chemoradiation, an abdominal MRI will be performed prior to or immediately after radiation treatment once per week during the any five weeks of treatment
|
| Liver Metastases Approximately 10 patients with liver mets will be enrolled to the study with the primary aim of determining the feasibility of using off-line MRI-guidance during the course of radiation treatment |
Other: MRI
Patients who consent to this study will have an abdominal MRI prior to or immediately after each fraction of radiation treatment in the case of those patients that are undergoing SBRT or those receiving palliative treatment. On patients receiving definitive chemoradiation, an abdominal MRI will be performed prior to or immediately after radiation treatment once per week during the any five weeks of treatment
|
| Hepatocellular carcinoma Approximately 10 patients with HCC will be enrolled to the study with the primary aim of determining the feasibility of using off-line MRI-guidance during the course of radiation treatment |
Other: MRI
Patients who consent to this study will have an abdominal MRI prior to or immediately after each fraction of radiation treatment in the case of those patients that are undergoing SBRT or those receiving palliative treatment. On patients receiving definitive chemoradiation, an abdominal MRI will be performed prior to or immediately after radiation treatment once per week during the any five weeks of treatment
|
Outcome Measures
Primary Outcome Measures
- Patient Satisfaction Survey [At study completion (day5 or week 5, depending on type of treatment)]
To evaluate patient satisfaction with the MR guidance process, a modified version of a questionnaire previously used at our institution will be performed at the end of the study
- MRI-Anxiety Questionnaire [Prior to or before MR session 1 (day 1 or week 1, depending on type of treatment)]
This instrument will be used to evaluate patient related anxiety after each MR
- MRI-Anxiety Questionnaire [Prior to or before MR session 2 (day 2 or week 2, depending on type of treatment)]
This instrument will be used to evaluate patient related anxiety after each MR
- MRI-Anxiety Questionnaire [Prior to or before MR session 3 (day 3 or week 3, depending on type of treatment)]
This instrument will be used to evaluate patient related anxiety after each MR
- MRI-Anxiety Questionnaire [Prior to or before MR session 4 (day 4 or week 4, depending on type of treatment)]
This instrument will be used to evaluate patient related anxiety after each MR
- MRI-Anxiety Questionnaire [Prior to or before MR session 5 (day 5 or week 5, depending on type of treatment)]
his instrument will be used to evaluate patient related anxiety after each MR
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients 18 years or older
-
Diagnosed with locally advanced pancreatic cancer or hepatocellular carcinoma being considered for treatment with chemoradiation, long course RT, or SBRT with curative intent or palliative intent, planned for 5 or more RT fractions
Exclusion Criteria:
- Contraindications for MRI: ferromagnetic prosthesis, pacemaker / implanted defibrillator, claustrophobia
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Health Network - Princess Margaret Cancer Centre | Toronto | Ontario | Canada | M5G 2M9 |
Sponsors and Collaborators
- University Health Network, Toronto
Investigators
- Principal Investigator: Laura Dawson, MD, University Health Network, Toronto
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 18-5176