MR7T-Healthy-PTX : Brain Exploration in Magnetic Resonance Imaging in Parallel Transmission Mode (pTX) at 7 Tesla
Study Details
Study Description
Brief Summary
Magnetic resonance imaging (MRI) is a non-invasive imaging modality used in routine clinical practice for clinical diagnosis by visualizing the anatomical structure and in vivo function of certain organs. The development of ultra-high field MRI systems with 7.0-T or higher, gives access to a new field of exploration of the human body by improving the speed of acquisition but also a better signal-to-noise ratio (SNR) and better resolution. In order to fully exploit the potential of these ultra-high field MRI scanners, various technical issues must be adressed. Indeed, the non-uniformity of the transmission field is one of them leading to non-uniform images with spatially varying contrast. Thus the pTX (parallel transmission) mode using multiple transmission channels allows spatial and temporal control over the RF waves.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: MRI A MRI on PTX mode will be done on healthy subjects (approx. 90 min of sequences) |
Other: MRI
A MRI in PTX mode will be done on healthy subject (approx. 90 min of sequences)
|
Outcome Measures
Primary Outcome Measures
- Evaluate the improvement of the Signal to Noise Ratio (SNR) in parallel transmission mode (pTx) versus without pTx at 7.0 T on different cerebral anatomical regions/structures (central gray nuclei, cerebellum, white matter, cortex). [1 year]
The main evaluation criterion is the value of the signal-to-noise ratio in a global way but also by a unit comparison approach (voxel to voxel). It will be a question of linking these variations to the flip angles but also to the probable inhomogeneities of the B1+ field.
Secondary Outcome Measures
- Evaluation of the body temperature [1 year]
Measurement of body temperature in healthy volunteers using a forehead thermometer before and after examination
- Evaluation of anxiety before, during and after the MRI [1 year]
Measurement of the healthy subject's feelings about the exam (anxiety, heat, nausea) using a grid proposed at the end of the exam.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age ≥ 18 years old
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Subject with no MRI contraindications (metallic shine, pacemaker)
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Free subject, without guardianship or curatorship or subordination
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A person affiliated to or beneficiary of a social security scheme.
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Informed and signed consent by the healthy volunteer after clear and fair information about the study
Exclusion Criteria:
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Subject with a contraindication to MRI (pregnancy, ocular metallic foreign body (accidental or other shrapnel); pacemaker (cardiac stimulator), implantable defibrillator, non MRI 7.0 T compatible neurostimulator, cochlear implants and generally any irremovably implanted electronic medical device; metallic heart valve, vascular clips formerly implanted on cranial aneurysm), metallic prostheses.
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Healthy volunteers suffering from claustrophobia
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Persons not benefiting from a Social Security scheme or not benefiting from it through a third party.
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Persons benefiting from reinforced protection, i.e. minors, pregnant and breastfeeding women, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and finally, patients in emergency situations.
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Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CHU de Poitiers | Poitiers | France | 86000 |
Sponsors and Collaborators
- Poitiers University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2019-A02689-48