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MTF Image Modifications

Sponsor
Medical University of Vienna (Other)
Overall Status
Completed
CT.gov ID
NCT01926704
Collaborator
(none)
30
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Human visual acuity and contrast sensitivity are highly dependent on various different parameters. Each should be optimized for perfect visual performance. However, in real life our eyes lack such parameters, which might lead to unsatisfying results even after spectacle correction or contact lenses.

A promising approach would be to design intra ocular lenses (IOL), which are implanted into the eye for example in the course of cataract extraction and are able to compensate for the human eyes' aberrations.

For example cutoff frequency, edge-sharpness or specific contrast for selected structure sizes would need to be considered. Since, an aberration free optical system is almost impossible and since the impact of each single parameter is not yet known, IOL design parameters would have to be chosen very carefully.

Furthermore, image quality of IOLs still is tested ex vivo by ray tracing for example, but this does not guarantee perfect function after implantation, as our visual system has complex image precessing units form the retina to the brain.

The present study picks one of these parameters and seeks to assess its impact on visual quality in-vivo. By subjectively grading different images with objective changes to image quality by variations of the modulation transfer function (MTF), the potential influence and thus on our subjective visual impression shall be assessed.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    30 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    A Pilotstudy Investigating the Impact of Image Modifications on Subjective Image Quality
    Study Start Date :
    Oct 1, 2013
    Actual Primary Completion Date :
    Oct 1, 2013

    Arms and Interventions

    Arm Intervention/Treatment
    healthy, young subjects

    Outcome Measures

    Primary Outcome Measures

    1. subjective image quality [1 study day]

    Secondary Outcome Measures

    1. subjective image sharpness [1 study day]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 35 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Men and women aged between 18 and 35 years, nonsmokers

    • Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant

    • Normal ophthalmic findings, emmetropia or ≤ 1 diopter

    Exclusion Criteria:

    • Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study

    • Treatment in the previous 3 weeks with any drug (except oral contraceptives)

    • Symptoms of a clinically relevant illness in the 3 weeks before the first study day

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Department of Clinical Pharmacology, Medical University of Vienna Vienna Austria 1080

    Sponsors and Collaborators

    • Medical University of Vienna

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Gerhard Garhofer, assoc. Prof. Dr.med.univ., Medical University of Vienna
    ClinicalTrials.gov Identifier:
    NCT01926704
    Other Study ID Numbers:
    • OPHT - 210613
    First Posted:
    Aug 21, 2013
    Last Update Posted:
    Feb 19, 2014
    Last Verified:
    Feb 1, 2014
    Additional relevant MeSH terms:
    Hypersensitivity

    Study Results

    No Results Posted as of Feb 19, 2014